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Required for normal cytokinesis during mitosis. Plays a role in the regulation of cell proliferation. May be a component of the chromosomal passenger complex (CPC), a complex that acts as a key regulator of mitosis. The CPC complex has essential functions at the centromere in ensuring correct chromosome alignment and segregation and is required for chromatin-induced microtubule stabilization and spindle assembly. Increases AURKB activity. Inhibits apoptosis induced by TGFB1 By similarity. Overexpression induces swelling of mitochondria and reduces mitochondrial membrane potential.
Gene Name: | jumping translocation breakpoint |
Synonyms: | JTB, HSPC222, HJT, PAR protein, Protein JTB, PAR, HJTB |
Target Sequences: | NM_006694 NP_006685.1 O76095 |
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