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ITSN1 / ITSN

intersectin 1 (SH3 domain protein)

Acts as guanine nucleotide exchange factor (GEF) specific for the CDC42 GTPase (By similarity). Adapter protein that may provide indirect link between the endocytic membrane traffic and the actin assembly machinery. May regulate the formation of clathrin-coated vesicles. Involved in endocytosis of integrin beta-1 (ITGB1) and transferrin receptor (TFR); internalization of ITGB1 as DAB2-dependent cargo but not TFR may involve association with DAB2. Isoform 1 could be involved in brain-specific synaptic vesicle recycling. Inhibits ARHGAP31 activity toward RAC1.

Gene Name: intersectin 1 (SH3 domain protein)
Synonyms: ITSN1, Intersectin 1, ITSN, Intersectin-1, Intersectin short variant 12, SH3P17, SH3D1A
Target Sequences: NM_003024 NP_003015.2 Q15811

Publications (1)

1
Cytoskeletal regulation by AUTS2 in neuronal migration and neuritogenesis. Hori K, Nagai T, Shan W, Sakamoto A, Taya S, Hashimoto R, Hayashi T, Abe M, Yamazaki M, Nakao K, Nishioka T, Sakimura K, Yamada K, Kaibuchi K, Hoshino M. Cell reports. 2014 9:2166-79. (WB; Mouse) [Full Text Article] [PubMed:25533347]

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Proteins (4)
Over-Expression Lysate (2)
Recombinant (2)
ITSN1 / ITSN (4)
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GST, N-terminus (1)
His-T7 (1)
Myc-DDK (Flag) (2)
Human (2)
Rat (1)
293T Cells (1)
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HEK 293 Cells (1)
Wheat Germ Extract (1)
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HEK 293 Cells
Myc-DDK (Flag)
195.9 kDa
100 µg/$710
ITSN1 / ITSN Protein - Recombinant  Intersectin 1 By SDS-PAGE
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E. coli
His-T7
27.6 kDa
10 µg/$279; 50 µg/$432; 100 µg/$690; 200 µg/$862; 1 mg/$1,962; 500 µg/$1,505; 5 mg/$3,011; 2 mg/$2,148
ITSN1 / ITSN Protein - 12.5% SDS-PAGE Stained with Coomassie Blue.
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Wheat Germ Extract
GST, N-terminus
10 µg/$479; 25 µg/$670
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293T Cells
Myc-DDK (Flag)
195.9 kDa
20 µg/$215
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PLEASE NOTE

For RESEARCH USE ONLY. Intended for use by laboratory professionals. Not intended for human diagnostic or therapeutic purposes.

The data on this page has been compiled from LifeSpan internal sources, the National Center for Biotechnology Information (NCBI), and The Universal Protein Resource (UniProt).