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ITPR1 / IP3 Receptor Type 1

inositol 1,4,5-trisphosphate receptor, type 1

This gene encodes an intracellular receptor for inositol 1,4,5-trisphosphate. Upon stimulation by inositol 1,4,5-trisphosphate, this receptor mediates calcium release from the endoplasmic reticulum. Mutations in this gene cause spinocerebellar ataxia type 15, a disease associated with an heterogeneous group of cerebellar disorders. Multiple transcript variants have been identified for this gene.

Gene Name:	inositol 1,4,5-trisphosphate receptor, type 1
Family/Subfamily:	Ion Channel , Inositol 1,4,5-triphosphate receptor
Synonyms:	ITPR1, InsP3R-I, IP3R1, InsP3R, InsP3R type I, INSP3R1, IP3R, Opisthotonus, Pcp1, IP3 receptor, IP3 receptor isoform 1, SCA15, Spinocerebellar ataxia 15, Spinocerebellar ataxia 16, I145TR, IP3R 1, KIAA1754, SCA16, Type 1 InsP3 receptor
Target Sequences:	NM_001099952 NP_002213.5 Q14643

Publications (4)

The signalling receptor MCAM coordinates apical-basal polarity and planar cell polarity during morphogenesis. Gao Q, Zhang J, Wang X, Liu Y, He R, Liu X, Wang F, Feng J, Yang D, Wang Z, Meng A, Yan X. Nature communications. 2017 8:15279. (WB; Human) [Full Text Article] [PubMed:28589943] [PMC:PMC5467231]

PC-PLC is involved in osteoclastogenesis induced by TNF- alpha through upregulating IP3R1 expression. Xia L, Zhang D, Wang C, Wei F, Hu Y. FEBS letters. 2012 Sep;586:3341-8. [Full Text Article] [PubMed:22819818] Related Antibodies: LS-B2640.

Autoreactivity and exceptional CDR plasticity (but not unusual polyspecificity) hinder elicitation of the anti-HIV antibody 4E10. Finton KA, Larimore K, Larman HB, Friend D, Correnti C, Rupert PB, Elledge SJ, Greenberg PD, Strong RK. PLoS pathogens. 2013 9:e1003639. [Full Text Article] [PubMed:24086134] [PMC:PMC3784475] Related Antibodies: LS-B2627.

Receptor-interacting protein 140 attenuates endoplasmic reticulum stress in neurons and protects against cell death. Feng X, Krogh KA, Wu CY, Lin YW, Tsai HC, Thayer SA, Wei LN. Nature communications. 5:4487. [Full Text Article] [PubMed:25066731] [PMC:PMC4200015] Related Antibodies: LS-B6763.

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The data on this page has been compiled from LifeSpan internal sources, the National Center for Biotechnology Information (NCBI), and The Universal Protein Resource (UniProt).

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