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ITPKA
inositol-trisphosphate 3-kinase A
Regulates inositol phosphate metabolism by phosphorylation of second messenger inositol 1,4,5-triphosphate to Ins(1,3,4,5)P4. The activity of the inositol 1,4,5-triphosphate 3-kinase is responsible for regulating the levels of a large number of inositol polyphosphates that are important in cellular signaling. Both calcium/calmodulin and protein phosphorylation mechanisms control its activity. It is also a substrate for the cyclic AMP-dependent protein kinase, calcium/calmodulin- dependent protein kinase II, and protein kinase C in vitro. ITPKA and ITPKB are 68% identical in the C-terminus region.
| Gene Name: | inositol-trisphosphate 3-kinase A |
| Family/Subfamily: | Non-protein Kinase , ITPK |
| Synonyms: | ITPKA, IP3-3KA, IP3KA, InsP 3-kinase A, IP3 3-kinase A, IP3K A |
| Target Sequences: | NM_002220 NP_002211.1 P23677 |
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