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ITM2C

integral membrane protein 2C

Negative regulator of beta amyloid peptide production. May inhibit the processing of APP by blocking its access to alpha- and beta-secretase. Binding to the beta-secretase-cleaved APP C-terminal fragment is negligible, suggesting that ITM2C is a poor gamma-secretase cleavage inhibitor. May play a role in TNF-induced cell death and neuronal differentiation.

Gene Name:	integral membrane protein 2C
Synonyms:	ITM2C, BRICHOS domain containing 2C, BRICD2C, Cerebral protein 14, E25C, E25, Integral membrane protein 2C, Integral membrane protein 3, HRPC.1050_D_4, ITM3, Transmembrane protein BRI3
Target Sequences:	NM_030926 NP_112188.1 Q9NQX7

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The data on this page has been compiled from LifeSpan internal sources, the National Center for Biotechnology Information (NCBI), and The Universal Protein Resource (UniProt).

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