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ITGAX / CD11c

integrin, alpha X (complement component 3 receptor 4 subunit)

ITGAX / CD11c is the integrin alpha X chain protein. Integrins are heterodimeric integral membrane proteins composed of an alpha chain and a beta chain. This protein combines with the beta 2 chain (ITGB2) to form a leukocyte-specific integrin referred to as inactivated-C3b (iC3b) receptor 4 (CR4). The alpha X beta 2 complex seems to overlap the properties of the alpha M beta 2 integrin in the adherence of neutrophils and monocytes to stimulated endothelium cells, and in the phagocytosis of complement coated particles. Two transcript variants encoding different isoforms have been found for this gene.

Gene Name: integrin, alpha X (complement component 3 receptor 4 subunit)
Family/Subfamily: Integrin , not assigned-Integrin
Synonyms: ITGAX, CD11c antigen, Integrin alpha-X, Leu M5, alpha subunit, p150 95 integrin alpha chain, SLEB6, CD11C, Leu M5
Target Sequences: NM_000887 NP_000878.2 P20702

Publications (5)

1
CD11c/CD18: novel ligands and a role in delayed-type hypersensitivity. Sadhu C, Ting HJ, Lipsky B, Hensley K, Garcia-Martinez LF, Simon SI, Staunton DE. Journal of leukocyte biology. 2007 81:1395-403. [PubMed:17389580] Related Antibodies: LS-C40809.
2
Targeting the nuclear antigen 1 of Epstein-Barr virus to the human endocytic receptor DEC-205 stimulates protective T-cell responses. Gurer C, Strowig T, Brilot F, Pack M, Trumpfheller C, Arrey F, Park CG, Steinman RM, Mnz C. Blood. 2008 112:1231-9. [PubMed:18519810] [PMC:PMC2515117] Related Antibodies: LS-C40809.
3
Phosphatidylcholine hydroperoxide-induced THP-1 cell adhesion to intracellular adhesion molecule-1. Asai A, Okajima F, Nakagawa K, Ibusuki D, Tanimura K, Nakajima Y, Nagao M, Sudo M, Harada T, Miyazawa T, Oikawa S. Journal of lipid research. 2009 50:957-65. [PubMed:19114730] [PMC:PMC2666182] Related Antibodies: LS-C40809.
4
Abundant immunoglobulin E-positive cells in skin lesions support an allergic etiology of atopic dermatitis in the elderly. Tanei R, Hasegawa Y, Sawabe M. Journal of the European Academy of Dermatology and Venereology : JEADV. 2013 27:952-60. (ICC; Human) [Full Text Article] [PubMed:22702954] [PMC:PMC3818699]
5
Dendritic cells in semen of infertile men: association with sperm quality and inflammatory status of the epididymis. Duan YG, Zhang Q, Liu Y, Mou L, Li G, Gui Y, Cai Z. Fertility and sterility. 2014 101:70-77. (ICC; Human) [Full Text Article] [PubMed:24083871]
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For RESEARCH USE ONLY. Intended for use by laboratory professionals. Not intended for human diagnostic or therapeutic purposes.

The data on this page has been compiled from LifeSpan internal sources, the National Center for Biotechnology Information (NCBI), and The Universal Protein Resource (UniProt).