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ITGAM / CD11b

integrin, alpha M (complement component 3 receptor 3 subunit)

Integrin alpha-M/beta-2 is implicated in various adhesive interactions of monocytes, macrophages and granulocytes as well as in mediating the uptake of complement-coated particles. It is identical with CR-3, the receptor for the iC3b fragment of the third complement component. It probably recognizes the R-G-D peptide in C3b. Integrin alpha-M/beta-2 is also a receptor for fibrinogen, factor X and ICAM1. It recognizes P1 and P2 peptides of fibrinogen gamma chain.

Gene Name: integrin, alpha M (complement component 3 receptor 3 subunit)
Family/Subfamily: Integrin , not assigned-Integrin
Synonyms: ITGAM, Antigen CD11b (p170), CD11B, CD11b antigen, CR3A, Integrin alpha-M, MAC-1, MO1A, Neutrophil adherence receptor, MAC1A, SLEB6, CR-3 alpha chain
Target Sequences: NM_000632 NP_000623.2 P11215

Publications (21)

1
Dissection of the hyperadhesive phenotype of airway eosinophils in asthma. Barthel SR, Jarjour NN, Mosher DF, Johansson MW. American journal of respiratory cell and molecular biology. 2006 35:378-86. [PubMed:16601240] [PMC:PMC1550734] Related Antibodies: LS-C40808.
2
Functional heterogeneity and differential priming of circulating neutrophils in human experimental endotoxemia. Pillay J, Ramakers BP, Kamp VM, Loi AL, Lam SW, Hietbrink F, Leenen LP, Tool AT, Pickkers P, Koenderman L. Journal of leukocyte biology. 2010 88:211-20. [PubMed:20400675] Related Antibodies: LS-C40808.
3
Basophils and the T helper 2 environment can promote the development of lupus nephritis. Charles N, Hardwick D, Daugas E, Illei GG, Rivera J. Nature medicine. 2010 16:701-7. [PubMed:20512127] [PMC:PMC2909583] Related Antibodies: LS-C40807.
4
Terminal differentiation of chronic myelogenous leukemia cells is induced by targeting of the MUC1-C oncoprotein. Yin L, Ahmad R, Kosugi M, Kawano T, Avigan D, Stone R, Kharbanda S, Kufe D. Cancer biology & therapy. 2010 10:483-91. (IHC; Human) [PubMed:20592495] [PMC:PMC3034602]
5
Gelatinase contributes to the pathogenesis of endocarditis caused by Enterococcus faecalis. Thurlow LR, Thomas VC, Narayanan S, Olson S, Fleming SD, Hancock LE. Infection and immunity. 2010 78:4936-43. [PubMed:20713628] [PMC:PMC2976315] Related Antibodies: LS-C40807.
6
Toll-like receptor 4 mediates the response of epithelial and stromal cells to lipopolysaccharide in the endometrium. Sheldon IM, Roberts MH. PloS one. 2010 5:e12906. (IHC; Mouse) [PubMed:20877575] [PMC:PMC2943929]
7
The Vi capsular polysaccharide prevents complement receptor 3-mediated clearance of Salmonella enterica serotype Typhi. Wilson RP, Winter SE, Spees AM, Winter MG, Nishimori JH, Sanchez JF, Nuccio SP, Crawford RW, Tkel, Bumler AJ. Infection and immunity. 2011 79:830-7. [PubMed:21098104] [PMC:PMC3028862] Related Antibodies: LS-C40808.
8
Altered hippocampal synaptic transmission in transgenic mice with astrocyte-targeted enhanced CCL2 expression. Nelson TE, Hao C, Manos J, Ransohoff RM, Gruol DL. Brain, behavior, and immunity. 2011 S106-19. (WB; Mouse) [PubMed:21356306]
9
MUC1-C oncoprotein suppresses reactive oxygen species-induced terminal differentiation of acute myelogenous leukemia cells. Yin L, Wu Z, Avigan D, Rosenblatt J, Stone R, Kharbanda S, Kufe D. Blood. 2011 117:4863-70. [PubMed:21422470] [PMC:PMC3100696]
10
Hax1 regulates neutrophil adhesion and motility through RhoA. Cavnar PJ, Berthier E, Beebe DJ, Huttenlocher A. The Journal of cell biology. 2011 193:465-73. [PubMed:21518791] [PMC:PMC3087009] Related Antibodies: LS-C40808.
11
Infection of dendritic cells with herpes simplex virus type 1 induces rapid degradation of CYTIP, thereby modulating adhesion and migration. Theodoridis AA, Eich C, Figdor CG, Steinkasserer A. Blood. 2011 118:107-15. [PubMed:21562043] Related Antibodies: LS-C40808.
12
Neuroadaptive changes in cerebellar neurons induced by chronic exposure to IL-6. Gruol DL, Puro A, Hao C, Blakely P, Janneke E, Vo K. Journal of neuroimmunology. 2011 239:28-36. (WB; Rat) [PubMed:21890220] [PMC:PMC3428218]
13
Hypoxia-inducible factor 1 is a master regulator of breast cancer metastatic niche formation. Wong CC, Gilkes DM, Zhang H, Chen J, Wei H, Chaturvedi P, Fraley SI, Wong CM, Khoo US, Ng IO, Wirtz D, Semenza GL. Proceedings of the National Academy of Sciences of the United States of America. 2011 108:16369-74. (IHC, WB, IHC-P; Mouse, Human) [PubMed:21911388] [PMC:PMC3182724]
14
Human eosinophils express RAGE, produce RAGE ligands, exhibit PKC-delta phosphorylation and enhanced viability in response to the RAGE ligand, S100B. Curran CS, Bertics PJ. International immunology. 2011 23:713-28. [PubMed:22025532] [PMC:PMC3226529] Related Antibodies: LS-C40808.
15
Inhibitors of hypoxia-inducible factor 1 block breast cancer metastatic niche formation and lung metastasis. Wong CC, Zhang H, Gilkes DM, Chen J, Wei H, Chaturvedi P, Hubbi ME, Semenza GL. Journal of molecular medicine (Berlin, Germany). 2012 90:803-15. (IHC; Mouse) [PubMed:22231744] [PMC:PMC3437551]
16
Altered synaptic transmission in the hippocampus of transgenic mice with enhanced central nervous systems expression of interleukin-6. Nelson TE, Olde Engberink A, Hernandez R, Puro A, Huitron-Resendiz S, Hao C, De Graan PN, Gruol DL. Brain, behavior, and immunity. 2012 26:959-71. (WB; Mouse) [PubMed:22609298] [PMC:PMC3427030]
17
Effect of molecular size and modification pattern on the internalization of water soluble -(1 3)-(1 4)-glucan by primary murine macrophages. Zhang M, Kim JA. The international journal of biochemistry & cell biology. 2012 44:914-27. (ICC; Mouse) [PubMed:22679629]
18
Human suppressive neutrophils CD16bright/CD62Ldim exhibit decreased adhesion. Kamp VM, Pillay J, Lammers JW, Pickkers P, Ulfman LH, Koenderman L. Journal of leukocyte biology. 2012 92:1011-20. [PubMed:22927481] Related Antibodies: LS-C40808.
19
Synaptic plasticity in the hippocampus shows resistance to acute ethanol exposure in transgenic mice with astrocyte-targeted enhanced CCL2 expression. Bray JG, Reyes KC, Roberts AJ, Ransohoff RM, Gruol DL. Neuropharmacology. 2013 67:115-25. (WB; Mouse) [PubMed:23164616] [PMC:PMC3595200]
20
VEGFR1-positive macrophages facilitate liver repair and sinusoidal reconstruction after hepatic ischemia/reperfusion injury. Ohkubo H, Ito Y, Minamino T, Eshima K, Kojo K, Okizaki S, Hirata M, Shibuya M, Watanabe M, Majima M. PloS one. 2014 9:e105533. (WB, Flo; Mouse) [Full Text Article] [PubMed:25162491] [PMC:PMC4146544]
21
Frontline Science: Microbiota reconstitution restores intestinal integrity after cisplatin therapy. Perales-Puchalt A, Perez-Sanz J, Payne KK, Svoronos N, Allegrezza MJ, Chaurio RA, Anadon C, Calmette J, Biswas S, Mine JA, Costich TL, Nickels L, Wickramasinghe J, Rutkowski MR, Conejo-Garcia JR. Journal of leukocyte biology. 2018 May;103:799-805. [Full Text Article] [PubMed:29537705] [PMC:PMC6004318] Related Antibodies: LS-C141892.
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Products
Antibodies (317)
Primary (317)
ITGAM / CD11b (317)
Human (183)
Mouse (123)
Rat (67)
Baboon (4)
Bovine (4)
Cat (1)
Chimpanzee (3)
Cynomolgus (3)
Dog (2)
Goat (2)
Monkey (9)
Mustelid (1)
Non-Human Primate (4)
Non-Human Primates (10)
Pig (2)
Rabbit (13)
Rhesus monkey (2)
Sheep (1)
IHC (98)
IHC-Fr (48)
IHC-P (14)
WB (92)
Flo (206)
Block (4)
DB (1)
ELISA (21)
Func (26)
ICC (11)
IF (31)
IP (80)
Neut (1)
Peptide-ELISA (2)
Purif (1)
rabbit (95)
mouse (124)
goat (1)
chicken (2)
mouse-balb/c (1)
rat (94)
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IHCPlus (1)
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IgG (24)
IgG,k (1)
IgG1 (67)
IgG1,k (18)
IgG2a (46)
IgG2b (53)
IgG2b,k (31)
monoclonal mc (219)
polyclonal pc (96)
recombinant monoclonal rmc (2)
107 (1)
198 (1)
3A10H5 (1)
3A33 (14)
4E10 (1)
5C6 (5)
Bear-1 (1)
BEAR-1 (1)
C11b/660 (2)
CA16.3E10 (1)
CBRM1/5 (6)
CC126 (2)
ED7 (1)
ED8 (3)
F6.2 (3)
ICR44 (6)
ICRF44 (29)
ITGAM/271 (2)
L1 (1)
LT11 (1)
M1/70 (54)
M1/70.15 (11)
mCD11b (1)
MEM-170 (2)
MEM-174 (10)
OTI12C10 (2)
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BSA-free (2)
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Supernatant (1)
Unconjugated (108)
aa301-451 (16)
aa870-1004 (10)
aa248-430 (8)
aa253-282 (8)
aa31-160 (8)
aa598-700 (8)
aa808-931 (8)
Internal (2)
aa630-1104 (2)
Extracellular Domain (1)
Integrin a-M (1)
aa17-382 (1)
aa177-192 (1)
aa339-629 (1)
aa623-728 (1)
aa769-818 (1)
aa807-817 (1)
No (314)
Yes (3)
ITGAM / CD11b Antibody - Anti-CD11b antibody IHC of mouse spleen. Immunohistochemistry of formalin-fixed, paraffin-embedded tissue after heat-induced antigen retrieval. Antibody concentration 10 ug/ml.
Select
Neuroscience
ITGAM / CD11b Rat anti-Mouse Monoclonal (M1/70.15) Antibody
Rabbit, Mouse, Human
Flo, IF, IHC, IHC-Fr, IHC-P, IP
Unconjugated
0.05 mg/$440
ITGAM / CD11b Antibody - Human peripheral blood granulocytes stained with purified ICRF44, followed by anti-mouse IgGs FITC
Select
ITGAM / CD11b Mouse anti-Human Monoclonal (ICRF44) Antibody
Pig, Human, Monkey, Baboon
Flo, IHC, IHC-Fr
Unconjugated
100 µg/$230
ITGAM / CD11b Antibody - CD11b Antibody - Microglia Marker - IHC of CD11b in human renal cancer using DAB with hematoxylin counterstain.  This image was taken for the unconjugated form of this product. Other forms have not been tested.
Select
ITGAM / CD11b Rabbit anti-Mouse Polyclonal (Internal) Antibody
Mouse, Rat, Human
IHC, IHC-P, WB
Unconjugated
0.1 ml/$376
ITGAM / CD11b Antibody - CD11b antibody IHC-paraffin: Human Tonsil Tissue.
Select
ITGAM / CD11b Rabbit anti-Human Polyclonal (aa17-382) Antibody
Mouse, Rat, Human
IHC, IHC-P, WB
Unconjugated
100 µg/$421
Select
ITGAM / CD11b Mouse anti-Rat Monoclonal (OX-42) Antibody
Rat
IHC, IHC-Fr
Unconjugated
1000 µg/$769
ITGAM / CD11b Antibody - Western blot of recombinant ITGAM / CD11b. This image was taken for the base form of this product. Alternate forms, such as conjugated, azide-free, or ready-to-use, have not been tested.
Select
ITGAM / CD11b Rabbit anti-Mouse Polyclonal (aa248-430) Antibody
Mouse
WB
Unconjugated
100 µl/$297; 200 µl/$338; 500 µl/$475; 1 ml/$543
Select
ITGAM / CD11b Mouse anti-Bovine Monoclonal (FITC) Antibody
Goat, Sheep, Bovine
Flo
FITC Conjugated
100 µg/$842
Select
ITGAM / CD11b Rat anti-Mouse Monoclonal (M1/70.15) Antibody
Rabbit, Mouse, Human
Flo, Func, IHC, IHC-Fr, IP
Unconjugated
500 µg/$846
Select
ITGAM / CD11b Rat anti-Mouse Monoclonal (Azide-free) (M1/70.15) Antibody
Mouse, Human
Block, DB, Flo, Func, IHC, IHC-P, IP, WB
Unconjugated, Azide-free
1 mg/$550
Select
ITGAM / CD11b Mouse anti-Dog Monoclonal Antibody
Goat, Dog, Bovine, Pig, Cat, Mustelid
Flo, IHC, IHC-Fr, IP
Unconjugated
2 ml/$820
ITGAM / CD11b Antibody - SDS-PAGE Analysis of Purified, BSA-Free CD11b Antibody (clone M1/70). Confirmation of Integrity and Purity of the Antibody.
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ITGAM / CD11b Rat anti-Mouse Monoclonal (M1/70) Antibody
Rabbit, Mouse, Human, Baboon, Chimpanzee, Cynomolgus, Rhesus monkey
Block, ELISA, Flo, Func, IF, IHC, IHC-Fr, IP
Unconjugated
20 µg/$354; 100 µg/$550
ITGAM / CD11b Antibody - PMA activated human granulocytes stained with CBRM1/5 FITC
Select
ITGAM / CD11b Mouse anti-Human Monoclonal (CBRM1/5) Antibody
Human
Flo, IP
Unconjugated
100 µg/$262
Select
ITGAM / CD11b Chicken anti-Human Polyclonal Antibody
Human
IHC
Unconjugated
1000 µl/$622
ITGAM / CD11b Antibody - CD11b antibody immunohistochemistry of formalin-fixed and paraffin-embedded human hepatocarcinoma followed by peroxidase-conjugated secondary antibody and DAB staining.
Select
ITGAM / CD11b Rabbit anti-Human Polyclonal (aa253-282) Antibody
Human
Flo, IHC, IHC-P, WB
Unconjugated
400 µl/$381
Select
ITGAM / CD11b Mouse anti-Human Monoclonal (ICRF44) Antibody
Human
Flo, IHC, IHC-Fr, IP
Unconjugated
0.1 mg/$363
Select
ITGAM / CD11b Mouse anti-Human Monoclonal (FITC) (ICRF44) Antibody
Human
Flo, IHC, IHC-Fr
FITC Conjugated
25 µg/$266; 0.1 mg/$406
Select
ITGAM / CD11b Mouse anti-Human Monoclonal Antibody
Human, Monkey, Baboon, Cynomolgus
Flo, IHC, IHC-Fr, IP
Unconjugated
100 µg/$547; 200 µg/$742
Select
ITGAM / CD11b Mouse anti-Rat Monoclonal (Low Endotoxin) (OX-42) Antibody
Rat
Flo, IF, IHC-Fr, IP
Unconjugated, Low Endotoxin
0.5 mg/$645
ITGAM / CD11b Antibody - Surface staining of CD11b in murine peritoneal fluid with anti-CD11b (M1/70) PE.
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ITGAM / CD11b Rat anti-Mouse Monoclonal (PE) (M1/70) Antibody
Rabbit, Mouse, Human, Non-Human Primates
Flo, Func, IHC-Fr, IP
PE Conjugated
0.1 mg/$313
ITGAM / CD11b Antibody - IHC of CD11b antibody. Frozen section of human tonsil.
Select
ITGAM / CD11b Mouse anti-Human Monoclonal (X-5) Antibody
Human
IHC, IHC-Fr
Unconjugated
100 µg/$555
Select
ITGAM / CD11b Rat anti-Mouse Monoclonal (APC, Cy7) (3A33) Antibody
Mouse
Flo
APC, Cy7 Conjugated
0.1 mg/$378
Select
ITGAM / CD11b Rat anti-Mouse Monoclonal (Low Endotoxin) (M1/70.15) Antibody
Mouse
Flo, IF, IHC, IHC-Fr, IHC-P, IP
Unconjugated, Low Endotoxin
0.5 mg/$627
Select
ITGAM / CD11b Rat anti-Mouse Monoclonal (5C6) Antibody
Mouse
Flo, IF, IHC-Fr, IP
Unconjugated
0.25 mg/$514
ITGAM / CD11b Antibody - Immunofluorescence of HeLa cells using ITGAM mouse monoclonal antibody (green). Blue: DRAQ5 fluorescent DNA dye.
Select
ITGAM / CD11b Mouse anti-Human Monoclonal (aa623-728) (3A10H5) Antibody
Human
ELISA, IF, WB
Unconjugated
0.1 mg/$426
Select
ITGAM / CD11b Rabbit anti-Human Polyclonal (aa253-282) (FITC) Antibody
Human
ELISA, Flo, IHC, WB
FITC Conjugated
200 µl/$828
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The data on this page has been compiled from LifeSpan internal sources, the National Center for Biotechnology Information (NCBI), and The Universal Protein Resource (UniProt).