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ITGA2B / CD41

integrin, alpha 2b (platelet glycoprotein IIb of IIb/IIIa complex, antigen CD41)

Integrin alpha-IIb/beta-3 is a receptor for fibronectin, fibrinogen, plasminogen, prothrombin, thrombospondin and vitronectin. It recognizes the sequence R-G-D in a wide array of ligands. It recognizes the sequence H-H-L-G-G-G-A-K-Q-A-G-D-V in fibrinogen gamma chain. Following activation integrin alpha-IIb/beta-3 brings about platelet/platelet interaction through binding of soluble fibrinogen. This step leads to rapid platelet aggregation which physically plugs ruptured endothelial cell surface.

Gene Name: integrin, alpha 2b (platelet glycoprotein IIb of IIb/IIIa complex, antigen CD41)
Family/Subfamily: Integrin , not assigned-Integrin
Synonyms: ITGA2B, BDPLT2, CD41B, GT, gp2B, Integrin alpha-IIb, ITGAB, GPIIb, HPA3, Platelet-specific antigen BAK, CD41, CD41 antigen, GPalpha IIb, GTA
Target Sequences: NM_000419 NP_000410.2 P08514

Publications (1)

1
Comparison of serum and plasma as a source of blood extracellular vesicles: Increased levels of platelet-derived particles in serum extracellular vesicle fractions alter content profiles from plasma extracellular vesicle fractions. Xiaoman Zhang, Toshihide Takeuchi, Akiko Takeda, Hideki Mochizuki, Yoshitaka Nagai. PloS one. 2022 June;17:e0270634. [Full Text Article] [PubMed:35749554] [PMC:PMC9231772] Related Antibodies: LS-B13882.

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Proteins (7)
Over-Expression Lysate (2)
Recombinant (5)
ITGA2B / CD41 (7)
No (7)
GST, N-terminus (1)
His (1)
His-SUMO (1)
His-T7 (1)
Myc-DDK (Flag) (3)
Human (6)
293T Cells (1)
E. coli (2)
HEK 293 Cells (2)
Wheat Germ Extract (1)
Yeast (1)
ITGA2B / CD41 Protein - Western validation with an anti-DDK antibody * L: Control HEK293 lysate R: Over-expression lysate
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HEK 293 Cells
Myc-DDK (Flag)
113.37 kDa
100 µg/$710
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E. coli
His-SUMO
42.97 kD
1 mg/$1,355; 100 µg/$420; 20 µg/$323
ITGA2B / CD41 Protein
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Yeast
His
28.98 kD
100 µg/$446; 20 µg/$336; 1 mg/$1,460
ITGA2B / CD41 Protein - Recombinant  Integrin Alpha 2B By SDS-PAGE
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E. coli
His-T7
20.8 kDa
10 µg/$273; 50 µg/$392; 100 µg/$625; 200 µg/$782; 1 mg/$1,847; 500 µg/$1,404; 5 mg/$2,807; 2 mg/$2,029
ITGA2B / CD41 Protein - Western validation with an anti-DDK antibody * L: Control HEK293 lysate R: Over-expression lysate
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293T Cells
Myc-DDK (Flag)
113.37 kDa
20 µg/$215
ITGA2B / CD41 Protein - 12.5% SDS-PAGE Stained with Coomassie Blue.
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Wheat Germ Extract
GST, N-terminus
10 µg/$479; 25 µg/$670
ITGA2B / CD41 Protein - Purified recombinant protein ITGA2B was analyzed by SDS-PAGE gel and Coomassie Blue Staining
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HEK 293 Cells
Myc-DDK (Flag)
110 kDa
20 µg/$1,107
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For RESEARCH USE ONLY. Intended for use by laboratory professionals. Not intended for human diagnostic or therapeutic purposes.

The data on this page has been compiled from LifeSpan internal sources, the National Center for Biotechnology Information (NCBI), and The Universal Protein Resource (UniProt).