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ISCU

iron-sulfur cluster assembly enzyme

Iron-sulfur (Fe-S) clusters are necessary for several mitochondrial enzymes and other subcellular compartment proteins. They contain sulfur and iron, and are created via several steps that include cysteine desulfurases, iron donors, chaperones, and scaffold proteins. This gene encodes the two isomeric forms, ISCU1 and ISCU2, of the Fe-S cluster scaffold protein. Mutations in this gene have been found in patients with myopathy with severe exercise intolerance and myoglobinuria. A pseudogene of this gene is present on chromosome 1. Alternative splicing results in multiple transcript variants encoding different isoforms.

Gene Name: iron-sulfur cluster assembly enzyme
Synonyms: ISCU, ISU2, NifU-like protein, NIFUN, HML, NIFU, HnifU
Target Sequences: AK022758 AAG37428.1 Q9H1K1

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Products
Proteins (10)
Over-Expression Lysate (4)
Recombinant (6)
ISCU (10)
No (10)
GST (1)
GST, N-terminus (3)
His (1)
Myc-DDK (Flag) (5)
Human (8)
293T Cells (2)
E. coli (3)
HEK 293 Cells (3)
Wheat Germ Extract (2)
Purified (4)
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Wheat Germ Extract
GST, N-terminus
94.6 kDa
2 µg/$439
ISCU Protein - (Tris-Glycine gel) Discontinuous SDS-PAGE (reduced) with 5% enrichment gel and 15% separation gel.
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E. coli
GST, N-terminus
45.0kDa
1 mg/$1,355; 100 µg/$420; 20 µg/$323
ISCU Protein - Western validation with an anti-DDK antibody * L: Control HEK293 lysate R: Over-expression lysate
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HEK 293 Cells
Myc-DDK (Flag)
15.1 kDa
100 µg/$494
ISCU Protein - 12.5% SDS-PAGE of human NIFUN stained with Coomassie Blue
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Wheat Germ Extract
GST
41.36 kDa
10 µg/$479; 25 µg/$670
ISCU Protein - (Tris-Glycine gel) Discontinuous SDS-PAGE (reduced) with 5% enrichment gel and 15% separation gel.
Select
E. coli
GST, N-terminus
1 mg/$1,355; 100 µg/$420; 20 µg/$323
ISCU Protein - Purified recombinant protein ISCU was analyzed by SDS-PAGE gel and Coomassie Blue Staining
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HEK 293 Cells
Myc-DDK (Flag)
15.1 kDa
20 µg/$1,107
ISCU Protein - Western validation with an anti-DDK antibody * L: Control HEK293 lysate R: Over-expression lysate
Select
293T Cells
Myc-DDK (Flag)
15.1 kDa
20 µg/$150
ISCU Protein - Western validation with an anti-DDK antibody * L: Control HEK293 lysate R: Over-expression lysate
Select
293T Cells
Myc-DDK (Flag)
17.8 kDa
20 µg/$150
ISCU Protein - Western validation with an anti-DDK antibody * L: Control HEK293 lysate R: Over-expression lysate
Select
HEK 293 Cells
Myc-DDK (Flag)
17.8 kDa
100 µg/$494
ISCU Protein
Select
E. coli
His
10 µg/$361; 50 µg/$739
Viewing 1-10 of 10 product results


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PLEASE NOTE

For RESEARCH USE ONLY. Intended for use by laboratory professionals. Not intended for human diagnostic or therapeutic purposes.

The data on this page has been compiled from LifeSpan internal sources, the National Center for Biotechnology Information (NCBI), and The Universal Protein Resource (UniProt).