IRS4

insulin receptor substrate 4

Acts as an interface between multiple growth factor receptors possessing tyrosine kinase activity, such as insulin receptor, IGF1R and FGFR1, and a complex network of intracellular signaling molecules containing SH2 domains. Involved in the IGF1R mitogenic signaling pathway. Promotes the AKT1 signaling pathway and BAD phosphorylation during insulin stimulation without activation of RPS6KB1 or the inhibition of apoptosis. Interaction with GRB2 enhances insulin-stimulated mitogen-activated protein kinase activity. May be involved in nonreceptor tyrosine kinase signaling in myoblasts. Plays a pivotal role in the proliferation/differentiation of hepatoblastoma cell through EPHB2 activation upon IGF1 stimulation. May play a role in the signal transduction in response to insulin and to a lesser extent in response to IL4 and GH on mitogenesis. Plays a role in growth, reproduction and glucose homeostasis. May act as negative regulators of the IGF1 signaling pathway by suppressing the function of IRS1 and IRS2.

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Products

Proteins (5)

Type

Over-Expression Lysate (2)

Recombinant (3)

Target

IRS4 (5)

Publications

No (5)

Tag

GST, N-terminus (1)

Myc-DDK (Flag) (2)

Species

Human (3)

Mouse (1)

Source

293T Cells (1)

E. coli (2)

HEK 293 Cells (1)

Wheat Germ Extract (1)

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Human IRS4 Protein (Over-Expression Lysate Myc-DDK (Flag)) (Full Length) - LS-G80125

Source:

293T Cells

Tag:

Myc-DDK (Flag)

Molecular Weight:

133.6 kDa

Price:

20 µg/$215

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Human IRS4 Protein (Recombinant GST, N-terminus) (aa850-950) - LS-G60734

Source:

Wheat Germ Extract

Tag:

GST, N-terminus

Price:

10 µg/$479; 25 µg/$670

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IRS4 Protein (Over-Expression Lysate Myc-DDK (Flag)) (Full Length) - LS-G100077

Source:

HEK 293 Cells

Tag:

Myc-DDK (Flag)

Molecular Weight:

133.6 kDa

Price:

100 µg/$710

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Human IRS4 Protein (Recombinant) (Met1-Arg196) - LS-G133637

Source:

E. coli

Tag:

None

Molecular Weight:

25.0kDa

Price:

10 µg/$283; 50 µg/$452; 200 µg/$902; 100 µg/$722; 1 mg/$2,016; 500 µg/$1,553; 5 mg/$3,151; 2 mg/$2,204

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Mouse IRS4 Protein (Recombinant) (Met1-Arg299) - LS-G133701

Source:

E. coli

Tag:

None

Molecular Weight:

36.4kDa

Price:

10 µg/$286; 50 µg/$472; 200 µg/$942; 100 µg/$752; 1 mg/$2,069; 500 µg/$1,600; 5 mg/$3,291; 2 mg/$2,257

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