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IRS1

insulin receptor substrate 1

May mediate the control of various cellular processes by insulin. When phosphorylated by the insulin receptor binds specifically to various cellular proteins containing SH2 domains such as phosphatidylinositol 3-kinase p85 subunit or GRB2. Activates phosphatidylinositol 3-kinase when bound to the regulatory p85 subunit.

Gene Name: insulin receptor substrate 1
Synonyms: IRS1, IRS-1, HIRS-1, Insulin receptor substrate 1
Target Sequences: NM_005544 NP_005535.1 P35568

Publications (4)

1
Antisense treatment of IGF-IR enhances chemosensitivity in squamous cell carcinomas of the head and neck. Liu S, Jin F, Dai W, Yu Y. European journal of cancer (Oxford, England : 1990). 2010 46:1744-51. (WB) [PubMed:20451373]
2
The reciprocal regulation of gamma-synuclein and IGF-I receptor expression creates a circuit that modulates IGF-I signaling. Li M, Yin Y, Hua H, Sun X, Luo T, Wang J, Jiang Y. The Journal of biological chemistry. 2010 285:30480-8. (WB) [PubMed:20670935] [PMC:PMC2945541]
3
Phospho-?Np63a/microRNA network modulates epigenetic regulatory enzymes in squamous cell carcinomas. Ratovitski EA. Cell cycle (Georgetown, Tex.). 2014 13:749-61. (WB; Human) [Full Text Article] [PubMed:24394434] [PMC:PMC3979911]
4
The Medial Septum Is Insulin Resistant in the AD Presymptomatic Phase: Rescue by Nerve Growth Factor-Driven IRS1<sub> Activation. Sposato V, Canu N, Fico E, Fusco S, Bolasco G, Ciotti MT, Spinelli M, Mercanti D, Grassi C, Triaca V, Calissano P. Molecular neurobiology. 2019 January;56:535-552. [Full Text Article] [PubMed:29736736] [PMC:PMC6334735] Related Antibodies: LS-B1373.
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Proteins (5)
Over-Expression Cell Culture Supernatant (1)
Over-Expression Lysate (3)
Recombinant (1)
IRS1 (5)
No (5)
6His, N-terminus (2)
His-T7 (1)
Myc-DDK (Flag) (2)
Human (4)
Mouse (1)
293T Cells (1)
E. coli (1)
HEK 293 Cells (3)
IRS1 Protein - Western validation with an anti-DDK antibody * L: Control HEK293 lysate R: Over-expression lysate
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HEK 293 Cells
Myc-DDK (Flag)
131.4 kDa
100 µg/$494
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HEK 293 Cells
6His, N-terminus
68 kDa
100 µg/$298
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HEK 293 Cells
6His, N-terminus
68 kDa
200 µl/$283
IRS1 Protein - Western validation with an anti-DDK antibody * L: Control HEK293 lysate R: Over-expression lysate
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293T Cells
Myc-DDK (Flag)
131.4 kDa
20 µg/$150
IRS1 Protein - Recombinant Insulin Receptor Substrate 1 By SDS-PAGE
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E. coli
His-T7
31.2 kDa
10 µg/$276; 50 µg/$412; 100 µg/$657; 200 µg/$822; 1 mg/$1,905; 500 µg/$1,455; 5 mg/$2,871; 2 mg/$2,090
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For RESEARCH USE ONLY. Intended for use by laboratory professionals. Not intended for human diagnostic or therapeutic purposes.

The data on this page has been compiled from LifeSpan internal sources, the National Center for Biotechnology Information (NCBI), and The Universal Protein Resource (UniProt).