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IRF6

interferon regulatory factor 6

IRF6 is a member of the interferon regulatory transcription factor (IRF) family. Family members share a highly-conserved N-terminal helix-turn-helix DNA-binding domain and a less conserved C-terminal protein-binding domain. The encoded protein may be a transcriptional activator. Mutations in this gene can cause van der Woude syndrome and popliteal pterygium syndrome. Mutations in this gene are also associated with non-syndromic orofacial cleft type 6. Alternate splicing results in multiple transcript variants.

Gene Name: interferon regulatory factor 6
Synonyms: IRF6, Interferon regulatory factor 6, OFC6, PPS1, VWS, VWS1, IRF-6, LPS, PIT, PPS, Van der Woude syndrome
Target Sequences: NM_006147 NP_006138.1 O14896

Publications (2)

1
Full Spectrum of Postnatal Tooth Phenotypes in a Novel Irf6 Cleft Lip Model. Chu EY, Tamasas B, Fong H, Foster BL, LaCourse MR, Tran AB, Martin JF, Schutte BC, Somerman MJ, Cox TC. Journal of dental research. 2016 October;95:1265-73. (Human) [Full Text Article] [PubMed:27369589] [PMC:PMC5076757] Related Antibodies: LS-B3231.
2
Hailey-Hailey disease: investigation of a possible compensatory SERCA2 up-regulation and analysis of SPCA1, p63, and IRF6 expression. Zhang D, Li X, Wang Z, Zhang Y, Guo K, Wang S, Tu C, Huo J, Xiao S. Archives of dermatological research. Mar;307:143-9. [Full Text Article] [PubMed:25256005] Related Antibodies: LS-B3231.

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PLEASE NOTE

For RESEARCH USE ONLY. Intended for use by laboratory professionals. Not intended for human diagnostic or therapeutic purposes.

The data on this page has been compiled from LifeSpan internal sources, the National Center for Biotechnology Information (NCBI), and The Universal Protein Resource (UniProt).