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IRAK3 / IRAKM / IRAK-M
interleukin-1 receptor-associated kinase 3
IRAK3 / IRAKM / IRAK-M is a member of the interleukin-1 receptor-associated kinase protein family. Members of this family are essential components of the Toll/IL-R immune signal transduction pathways. This protein is primarily expressed in monocytes and macrophages and functions as a negative regulator of Toll-like receptor signaling. Mutations in this gene are associated with a susceptibility to asthma. Alternate splicing results in multiple transcript variants.
| Gene Name: | interleukin-1 receptor-associated kinase 3 |
| Family/Subfamily: | Protein Kinase , IRAK(Pelle) |
| Synonyms: | IRAK3, ASRT5, IRAK M, IRAK-3, IL1RAK M, IRAK-M, IRAKM |
| Target Sequences: | NM_007199 NP_009130.2 Q9Y616 |
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