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INTS3

integrator complex subunit 3

Component of the Integrator complex. The Integrator complex is involved in the small nuclear RNAs (snRNA) U1 and U2 transcription and in their 3'-box-dependent processing. The Integrator complex is associated with the C-terminal domain (CTD) of RNA polymerase II largest subunit (POLR2A) and is recruited to the U1 and U2 snRNAs genes.Component of the SOSS complex, a multiprotein complex that functions downstream of the MRN complex to promote DNA repair and G2/M checkpoint. The SOSS complex associates with single-stranded DNA at DNA lesions and influences diverse endpoints in the cellular DNA damage response including cell-cycle checkpoint activation, recombinational repair and maintenance of genomic stability. The SOSS complex is required for efficient homologous recombination-dependent repair of double-strand breaks (DSBs) and ATM-dependent signaling pathways. In the SOSS complex, it is required for the assembly of the complex and for stabilization of the complex at DNA damage sites.

Gene Name: integrator complex subunit 3
Synonyms: INTS3, C1orf193, C1orf60, Integrator complex subunit 3, INT3, RP11-216N14.4, SOSS complex subunit A, Sensor of ssDNA subunit A, SOSS-A, RP11-216N14.2, Sensor of ssDNA A
Target Sequences: NM_023015 NP_075391.3 Q68E01

☰ Filters
Products
Antibodies (10)
Primary (10)
INTS3 (10)
Human (10)
Mouse (3)
Rat (1)
WB (6)
Flo (2)
ELISA (7)
IF (1)
IP (3)
Peptide-ELISA (1)
rabbit (10)
Ig (2)
IgG (8)
polyclonal pc (10)
Biotin Conjugated (1)
FITC Conjugated (1)
HRP Conjugated (1)
Unconjugated (7)
C-Terminus (1)
Internal (1)
aa1000-1043 (1)
aa950-1,000 (1)
No (10)
INTS3 Antibody - All lanes: Anti-INTS3 Antibody (C-Term) at 1:2000 dilution Lane 1: 293 whole cell lysate Lane 2: Hela whole cell lysate Lane 3: Jurkat whole cell lysate Lysates/proteins at 20 µg per lane. Secondary Goat Anti-Rabbit IgG, (H+L), Peroxidase conjugated at 1/10000 dilution. Predicted band size: 118 kDa Blocking/Dilution buffer: 5% NFDM/TBST.
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INTS3 Rabbit anti-Human Polyclonal (C-Terminus) Antibody
Human
ELISA, Flo, WB
Unconjugated
200 µl/$393
INTS3 Antibody - All lanes: Anti-INTS3 Antibody (Center) at 1:2000 dilution Lane 1: 293 whole cell lysate Lane 2: Hela whole cell lysate Lane 3: Jurkat whole cell lysate Lane 4: NIH/3T3 whole cell lysate Lysates/proteins at 20 µg per lane. Secondary Goat Anti-Rabbit IgG, (H+L), Peroxidase conjugated at 1/10000 dilution. Predicted band size: 118 kDa Blocking/Dilution buffer: 5% NFDM/TBST.
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INTS3 Rabbit anti-Human Polyclonal (Internal) Antibody
Mouse, Human
ELISA, Flo, WB
Unconjugated
200 µl/$393
INTS3 Antibody - Immunofluorescence staining of Hela cells diluted at 1:66, counter-stained with DAPI. The cells were fixed in 4% formaldehyde, permeabilized using 0.2% Triton X-100 and blocked in 10% normal Goat Serum. The cells were then incubated with the antibody overnight at 4°C.The Secondary antibody was Alexa Fluor 488-congugated AffiniPure Goat Anti-Rabbit IgG (H+L).
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INTS3 Rabbit anti-Human Polyclonal Antibody
Human
ELISA, IF
Unconjugated
50 µg/$294; 100 µg/$360
Select
INTS3 Rabbit anti-Human Polyclonal (HRP) Antibody
Human
ELISA
HRP Conjugated
50 µg/$294; 100 µg/$360
Select
INTS3 Rabbit anti-Human Polyclonal (Biotin) Antibody
Human
ELISA
Biotin Conjugated
50 µg/$294; 100 µg/$360
Select
INTS3 Rabbit anti-Human Polyclonal (FITC) Antibody
Human
ELISA
FITC Conjugated
50 µg/$294; 100 µg/$360
Select
INTS3 Rabbit anti-Human Polyclonal Antibody
Human
ELISA, IP, WB
Unconjugated
100 µg/$331
Select
INTS3 Rabbit anti-Human Polyclonal (aa950-1,000) Antibody
Mouse, Human
IP, WB
Unconjugated
10 µl/$295; 100 µl/$514
Select
INTS3 Rabbit anti-Human Polyclonal (aa1000-1043) Antibody
Human
IP, WB
Unconjugated
10 µl/$295; 100 µl/$514
INTS3 Antibody - Western blot analysis of extracts of mouse brain tissue using INTS3 antibody. The lane on the left was treated with blocking peptide.
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INTS3 Rabbit anti-Human Polyclonal Antibody
Mouse, Rat, Human
Peptide-ELISA, WB
Unconjugated
100 µl/$379; 200 µl/$421
Viewing 1-10 of 10 product results


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PLEASE NOTE

For RESEARCH USE ONLY. Intended for use by laboratory professionals. Not intended for human diagnostic or therapeutic purposes.

The data on this page has been compiled from LifeSpan internal sources, the National Center for Biotechnology Information (NCBI), and The Universal Protein Resource (UniProt).