INPPL1 / SHIP2

inositol polyphosphate phosphatase-like 1

Phosphatidylinositol (PtdIns) phosphatase that specifically hydrolyzes the 5-phosphate of phosphatidylinositol-3,4,5-trisphosphate (PtdIns(3,4,5)P3) to produce PtdIns(3,4)P2, thereby negatively regulating the PI3K (phosphoinositide 3-kinase) pathways. Plays a central role in regulation of PI3K-dependent insulin signaling, although the precise molecular mechanisms and signaling pathways remain unclear. While overexpression reduces both insulin-stimulated MAP kinase and Akt activation, its absence does not affect insulin signaling or GLUT4 trafficking. Confers resistance to dietary obesity. May act by regulating AKT2, but not AKT1, phosphorylation at the plasma membrane. Part of a signaling pathway that regulates actin cytoskeleton remodeling. Required for the maintenance and dynamic remodeling of actin structures as well as in endocytosis, having a major impact on ligand-induced EGFR internalization and degradation. Participates in regulation of cortical and submembraneous actin by hydrolyzing PtdIns(3,4,5)P3 thereby regulating membrane ruffling. Regulates cell adhesion and cell spreading. Required for HGF-mediated lamellipodium formation, cell scattering and spreading. Acts as a negative regulator of EPHA2 receptor endocytosis by inhibiting via PI3K-dependent Rac1 activation. Acts as a regulator of neuritogenesis by regulating PtdIns(3,4,5)P3 level and is required to form an initial protrusive pattern, and later, maintain proper neurite outgrowth. Acts as a negative regulator of the FC-gamma-RIIA receptor (FCGR2A). Mediates signaling from the FC-gamma-RIIB receptor (FCGR2B), playing a central role in terminating signal transduction from activating immune/hematopoietic cell receptor systems. Involved in EGF signaling pathway. Upon stimulation by EGF, it is recruited by EGFR and dephosphorylates PtdIns(3,4,5)P3. Plays a negative role in regulating the PI3K-PKB pathway, possibly by inhibiting PKB activity. Down-regulates Fc-gamma-R-mediated phagocytosis in macrophages independently of INPP5D/SHIP1. In macrophages, down-regulates NF-kappa-B-dependent gene transcription by regulating macrophage colony-stimulating factor (M-CSF)-induced signaling. May also hydrolyze PtdIns(1,3,4,5)P4, and could thus affect the levels of the higher inositol polyphosphates like InsP6. Involved in endochondral ossification.

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Proteins (4)

Type

Over-Expression Lysate (2)

Recombinant (2)

Target

INPPL1 / SHIP2 (4)

Publications

No (4)

Tag

GST, N-terminus (1)

His (1)

Myc-DDK (Flag) (2)

Species

Human (2)

Mouse (1)

Source

293T Cells (1)

E. coli (1)

HEK 293 Cells (1)

Wheat Germ Extract (1)

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Human INPPL1 / SHIP2 Protein (Recombinant GST, N-terminus) (aa1159-1258) - LS-G59003

Source:

Wheat Germ Extract

Tag:

GST, N-terminus

Price:

10 µg/$479; 25 µg/$670

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INPPL1 / SHIP2 Protein (Over-Expression Lysate Myc-DDK (Flag)) (Full Length) - LS-G118511

Source:

HEK 293 Cells

Tag:

Myc-DDK (Flag)

Molecular Weight:

138.4 kDa

Price:

100 µg/$710

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Mouse INPPL1 / SHIP2 Protein (Recombinant His) (aa33-262) - LS-G22378

Source:

E. coli

Tag:

His

Molecular Weight:

30.1 kD

Price:

1 mg/$1,679; 100 µg/$500; 20 µg/$364

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Human INPPL1 / SHIP2 Protein (Over-Expression Lysate Myc-DDK (Flag)) (Full Length) - LS-G81174

Source:

293T Cells

Tag:

Myc-DDK (Flag)

Molecular Weight:

138.4 kDa

Price:

20 µg/$215

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