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INPP5K / SKIP

inositol polyphosphate-5-phosphatase K

Inositol 5-phosphatase which acts on inositol 1,4,5-trisphosphate, inositol 1,3,4,5-tetrakisphosphate, phosphatidylinositol 4,5-bisphosphate and phosphatidylinositol 3,4,5-trisphosphate. Has 6-fold higher affinity for phosphatidylinositol 4,5-bisphosphate than for inositol 1,4,5-trisphosphate. May negatively regulate assembly of the actin cytoskeleton.

Gene Name: inositol polyphosphate-5-phosphatase K
Family/Subfamily: Inositol phosphatase , not assigned-Inositol phosphatase
Synonyms: INPP5K, SKIP, PPS
Target Sequences: NM_016532 NP_057616.2 Q9BT40

Publications (2)

1
Phosphoinositide 5-phosphatases SKIP and SHIP2 in ruffles, the endoplasmic reticulum and the nucleus: An update. Ana Raquel Ramos, Somadri Ghosh, Tara Suhel, Clément Chevalier, Eric Owusu Obeng, Bohumil Fafilek, Pavel Krejci, Benjamin Beck, Christophe Erneux. The Breast : official journal of the European Society of Mastology. 2020 Jan;;75:100660. [Full Text Article] [PubMed:31628071] Related Antibodies: LS-B10239.
2
Lipid phosphatases SKIP and SHIP2 regulate fibronectin-dependent cell migration in glioblastoma. Ana Raquel Ramos, Somadri Ghosh, Matthias Dedobbeleer, Pierre A Robe, Bernard Rogister, Christophe Erneux. The Breast : official journal of the European Society of Mastology. 2019 Mar;;286:1120-1135. [Full Text Article] [PubMed:30695232] Related Antibodies: LS-B10239.

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For RESEARCH USE ONLY. Intended for use by laboratory professionals. Not intended for human diagnostic or therapeutic purposes.

The data on this page has been compiled from LifeSpan internal sources, the National Center for Biotechnology Information (NCBI), and The Universal Protein Resource (UniProt).