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INPP5K / SKIP

inositol polyphosphate-5-phosphatase K

Inositol 5-phosphatase which acts on inositol 1,4,5-trisphosphate, inositol 1,3,4,5-tetrakisphosphate, phosphatidylinositol 4,5-bisphosphate and phosphatidylinositol 3,4,5-trisphosphate. Has 6-fold higher affinity for phosphatidylinositol 4,5-bisphosphate than for inositol 1,4,5-trisphosphate. May negatively regulate assembly of the actin cytoskeleton.

Gene Name:	inositol polyphosphate-5-phosphatase K
Family/Subfamily:	Inositol phosphatase , not assigned-Inositol phosphatase
Synonyms:	INPP5K, SKIP, PPS
Target Sequences:	NM_016532 NP_057616.2 Q9BT40

Publications (2)

Phosphoinositide 5-phosphatases SKIP and SHIP2 in ruffles, the endoplasmic reticulum and the nucleus: An update. Ana Raquel Ramos, Somadri Ghosh, Tara Suhel, Clément Chevalier, Eric Owusu Obeng, Bohumil Fafilek, Pavel Krejci, Benjamin Beck, Christophe Erneux. The Breast : official journal of the European Society of Mastology. 2020 Jan;;75:100660. [Full Text Article] [PubMed:31628071] Related Antibodies: LS-B10239.

Lipid phosphatases SKIP and SHIP2 regulate fibronectin-dependent cell migration in glioblastoma. Ana Raquel Ramos, Somadri Ghosh, Matthias Dedobbeleer, Pierre A Robe, Bernard Rogister, Christophe Erneux. The Breast : official journal of the European Society of Mastology. 2019 Mar;;286:1120-1135. [Full Text Article] [PubMed:30695232] Related Antibodies: LS-B10239.

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The data on this page has been compiled from LifeSpan internal sources, the National Center for Biotechnology Information (NCBI), and The Universal Protein Resource (UniProt).

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