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Inositol 5-phosphatase which acts on inositol 1,4,5-trisphosphate, inositol 1,3,4,5-tetrakisphosphate, phosphatidylinositol 4,5-bisphosphate and phosphatidylinositol 3,4,5-trisphosphate. Has 6-fold higher affinity for phosphatidylinositol 4,5-bisphosphate than for inositol 1,4,5-trisphosphate. May negatively regulate assembly of the actin cytoskeleton.
Gene Name: | inositol polyphosphate-5-phosphatase K |
Family/Subfamily: | Inositol phosphatase , not assigned-Inositol phosphatase |
Synonyms: | INPP5K, SKIP, PPS |
Target Sequences: | NM_016532 NP_057616.2 Q9BT40 |
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