INPP5D / SHIP1 / SHIP

inositol polyphosphate-5-phosphatase, 145kDa

Phosphatidylinositol (PtdIns) phosphatase that specifically hydrolyzes the 5-phosphate of phosphatidylinositol-3,4,5-trisphosphate (PtdIns(3,4,5)P3) to produce PtdIns(3,4)P2, thereby negatively regulating the PI3K (phosphoinositide 3-kinase) pathways. Acts as a negative regulator of B-cell antigen receptor signaling. Mediates signaling from the FC-gamma-RIIB receptor (FCGR2B), playing a central role in terminating signal transduction from activating immune/hematopoietic cell receptor systems. Acts as a negative regulator of myeloid cell proliferation/survival and chemotaxis, mast cell degranulation, immune cells homeostasis, integrin alpha-IIb/beta-3 signaling in platelets and JNK signaling in B-cells. Regulates proliferation of osteoclast precursors, macrophage programming, phagocytosis and activation and is required for endotoxin tolerance. Involved in the control of cell-cell junctions, CD32a signaling in neutrophils and modulation of EGF-induced phospholipase C activity. Key regulator of neutrophil migration, by governing the formation of the leading edge and polarization required for chemotaxis. Modulates FCGR3/CD16-mediated cytotoxicity in NK cells. Mediates the activin/TGF-beta-induced apoptosis through its Smad-dependent expression. May also hydrolyze PtdIns(1,3,4,5)P4, and could thus affect the levels of the higher inositol polyphosphates like InsP6.

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Proteins (3)

Type

Over-Expression Lysate (2)

Recombinant (1)

Target

INPP5D / SHIP1 / SHIP (3)

Publications

No (3)

Tag

Myc-DDK (Flag) (3)

Species

Human (2)

Source

293T Cells (1)

HEK 293 Cells (2)

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INPP5D / SHIP1 / SHIP Protein (Over-Expression Lysate Myc-DDK (Flag)) (Full Length) - LS-G115897

Source:

HEK 293 Cells

Tag:

Myc-DDK (Flag)

Molecular Weight:

133 kDa

Price:

100 µg/$710

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Human INPP5D / SHIP1 / SHIP Protein (Recombinant Myc-DDK (Flag)) (Full Length) - LS-G68188

Source:

HEK 293 Cells

Tag:

Myc-DDK (Flag)

Molecular Weight:

133 kDa

Price:

20 µg/$1,107

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Human INPP5D / SHIP1 / SHIP Protein (Over-Expression Lysate Myc-DDK (Flag)) (Full Length) - LS-G81620

Source:

293T Cells

Tag:

Myc-DDK (Flag)

Molecular Weight:

133 kDa

Price:

20 µg/$215

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