Menu
Products
Services
Research Areas
Resources
Contact Us
Distributors
Login
Quick Order
Cart
Login
Registration enables users to use special features of this website, such as past
order histories, retained contact details for faster checkout, review submissions, and special promotions.


Fields marked with a * are required.

Login
Quick Order
Services
Immunohistochemistry Services

Work with LifeSpan to design a custom immunohistochemistry to address your specific biological question. Outsource the entire localization process without having to worry about finding and characterizing target specific antibodies, sourcing and validating difficult-to-find tissues, and having the ability to interpret the resulting immunostaining in relation to complex human pathologies.

TCR Screening Services

Test your therapeutic antibodies in immunohistochemistry against a broad panel of normal frozen human tissue types in order to determine potential unintended binding. Our non-GLP TCR services are designed on the FDA recommendation outlined in their "Points to Consider in the Manufacture and Testing of Monoclonal Antibody Products for Human Use".

Research Areas
Cell Cycle Pathways
Protein Family And Group
Infectious Disease
Contact Us
LSBio
2401 Fourth Avenue Suite 900
Seattle WA 98121
Phone:
866-819-4732 (Toll Free North America
206-374-1102 (International)
Fax:
866-206-6909 (Toll Free North America)
206-577-4565 (International)
How To Buy - Details about how to buy our products.
Orders@LSBio.com - To submit a new order.
Customer.Support@LSBio.com - To submit questions about existing orders, pricing, availability, bulk quotes, froforma invoice requests, or other billing issues.
Technical.Support@LSBio.com - To request technical information about an LSBio product or its applications
Sales@LSBio.com - To request information about fee-for-service contract IHC studies, IHC reports, distribution agreements, or general business development.
Worldwide Distributors List - To find your local distributor if you're not within the United States.
Login
Registration enables users to use special features of this website, such as past
order histories, retained contact details for faster checkout, review submissions, and special promotions.


Fields marked with a * are required.

Login
Quick Order

INPP5D / SHIP1 / SHIP

inositol polyphosphate-5-phosphatase, 145kDa

Phosphatidylinositol (PtdIns) phosphatase that specifically hydrolyzes the 5-phosphate of phosphatidylinositol-3,4,5-trisphosphate (PtdIns(3,4,5)P3) to produce PtdIns(3,4)P2, thereby negatively regulating the PI3K (phosphoinositide 3-kinase) pathways. Acts as a negative regulator of B-cell antigen receptor signaling. Mediates signaling from the FC-gamma-RIIB receptor (FCGR2B), playing a central role in terminating signal transduction from activating immune/hematopoietic cell receptor systems. Acts as a negative regulator of myeloid cell proliferation/survival and chemotaxis, mast cell degranulation, immune cells homeostasis, integrin alpha-IIb/beta-3 signaling in platelets and JNK signaling in B-cells. Regulates proliferation of osteoclast precursors, macrophage programming, phagocytosis and activation and is required for endotoxin tolerance. Involved in the control of cell-cell junctions, CD32a signaling in neutrophils and modulation of EGF-induced phospholipase C activity. Key regulator of neutrophil migration, by governing the formation of the leading edge and polarization required for chemotaxis. Modulates FCGR3/CD16-mediated cytotoxicity in NK cells. Mediates the activin/TGF-beta-induced apoptosis through its Smad-dependent expression. May also hydrolyze PtdIns(1,3,4,5)P4, and could thus affect the levels of the higher inositol polyphosphates like InsP6.

Gene Name: inositol polyphosphate-5-phosphatase, 145kDa
Family/Subfamily: Inositol Phosphatase , not assigned-Inositol Phosphatase
Synonyms: INPP5D, p150Ship, SHIP, SHIP1, SHIP-1, Hp51CN, SIP-145
Target Sequences: NM_005541 NP_005532.2 Q92835

Viewing 1-25 of 40 items
INPP5D / SHIP1 / SHIP Antibody - Human Tonsil: Formalin-Fixed, Paraffin-Embedded (FFPE)
Select
Mouse Monoclonal [clone SHIP-01] (IgG2a) to Human INPP5D / SHIP1 / SHIP
Human
Flo, IHC, IHC-P, WB
Unconjugated
50µg   1mg/ml   $425.00
INPP5D / SHIP1 / SHIP Antibody - Anti-INPP5D / SHIP antibody IHC of human tonsil. Immunohistochemistry of formalin-fixed, paraffin-embedded tissue after heat-induced antigen retrieval. Antibody dilution 1:50.
Select
Rabbit Polyclonal (IgG) to Human INPP5D / SHIP1 / SHIP
Mouse, Rat, Human
IHC, IHC-P
Unconjugated
250µl   $425.00
INPP5D / SHIP1 / SHIP Antibody - Anti-INPP5D / SHIP1 / SHIP antibody IHC staining of human thymus. Immunohistochemistry of formalin-fixed, paraffin-embedded tissue after heat-induced antigen retrieval. Antibody dilution 1:50.
Select
Rabbit Polyclonal (IgG) to Human INPP5D / SHIP1 / SHIP
Mouse, Rat, Human
IHC, IHC-P, Peptide-ELISA, WB
Unconjugated
100µl   1mg/ml   $505.00
INPP5D / SHIP1 / SHIP Antibody - INPP5D / SHIP antibody Western blot of 1 Cell lysate. Antibody concentration 1 ug/ml.  This image was taken for the unconjugated form of this product. Other forms have not been tested.
Select
Rabbit Polyclonal to Human INPP5D / SHIP1 / SHIP
Mouse, Dog, Guinea pig, Bovine, Rat, Horse, Human, Monkey
WB
Unconjugated
100µl   0.5mg/ml   $365.00
INPP5D / SHIP1 / SHIP Antibody - Staining HepG2 cells by IF/ICC. The samples were fixed with PFA and permeabilized in 0.1% Triton X-100, then blocked in 10% serum for 45 min at 25°C. The primary antibody was diluted at 1:200 and incubated with the sample for 1 hour at 37°C. An Alexa Fluor 594 conjugated goat anti-rabbit IgG (H+L) antibody, diluted at 1/600, was used as secondary antibody.
Select
Rabbit Polyclonal (IgG) to Human INPP5D / SHIP1 / SHIP
Mouse, Rat, Human
ELISA, IF, WB
Unconjugated
100µl   1mg/ml   $325.00; 200µl   1mg/ml   $375.00
INPP5D / SHIP1 / SHIP Antibody - IHC analysis of SHIP using anti-SHIP antibody
Select
Rabbit Polyclonal to Human INPP5D / SHIP1 / SHIP
Human
IHC, IHC-P, WB
Unconjugated
100µg   $355.00
INPP5D / SHIP1 / SHIP Antibody - 1:100 staining human thyroid carcinoma tissue by IHC-P. The sample was formaldehyde fixed and a heat mediated antigen retrieval step in citrate buffer was performed. The sample was then blocked and incubated with the antibody for 1.5 hours at 22°C. An HRP conjugated goat anti-rabbit antibody was used as the secondary.
Select
Rabbit Polyclonal (IgG) to Human INPP5D / SHIP1 / SHIP
Mouse, Rat, Human
ELISA, IHC, WB
Unconjugated
100µl   1mg/ml   $325.00; 200µl   1mg/ml   $375.00
INPP5D / SHIP1 / SHIP Antibody - WB using SHIP-1 Antibody (SHIP-02)
Select
Mouse Monoclonal [clone SHIP-02] (IgG2a) to Human INPP5D / SHIP1 / SHIP
Human
Flo, WB
Unconjugated
100µg   $345.00
Select
Rabbit Polyclonal to Human INPP5D / SHIP1 / SHIP
Human
IHC, WB
Unconjugated
100µl   $365.00
Select
Mouse Monoclonal (IgG2a) to Human INPP5D / SHIP1 / SHIP
Human
ELISA, WB
Unconjugated
100µg   $475.00
Select
Mouse Monoclonal (IgG2a) to Human INPP5D / SHIP1 / SHIP
Human
ELISA, WB
HRP Conjugated
100µl   $650.00
Select
Mouse Monoclonal (IgG2a) to Human INPP5D / SHIP1 / SHIP
Human
ELISA, WB
Biotin Conjugated
100µl   $650.00
Select
Mouse Monoclonal (IgG2a) to Human INPP5D / SHIP1 / SHIP
Human
ELISA, WB
FITC Conjugated
100µl   $650.00
Select
Mouse Monoclonal (IgG2a) to Human INPP5D / SHIP1 / SHIP
Human
ELISA, WB
PE Conjugated
100µl   $650.00
Select
Mouse Monoclonal (IgG2a) to Human INPP5D / SHIP1 / SHIP
Human
ELISA, WB
AP Conjugated
100µl   $650.00
INPP5D / SHIP1 / SHIP Antibody - IHC testing of FFPE human tonsil tissue with SHIP1 antibody at 1ug/ml. Required HIER: steam section in pH6 citrate buffer for 20 min and allow to cool prior to staining.
Select
Rabbit Polyclonal (IgG) to Human INPP5D / SHIP1 / SHIP
Mouse, Rat, Human
IHC-P, WB
Unconjugated
100µg   $435.00
INPP5D / SHIP1 / SHIP Antibody - Western blot analysis of lysates from HepG2 cells treated with TNF 200NG/ML 30', using SHIP1 (Phospho-Tyr1021) Antibody.
Select
Rabbit Polyclonal (IgG) to Human INPP5D / SHIP1 / SHIP
Mouse, Rat, Human
ELISA, Peptide-ELISA, WB
Unconjugated
50µl   1mg/ml   $265.00; 100µl   1mg/ml   $325.00
Select
Rabbit Polyclonal (IgG) to Mouse INPP5D / SHIP1 / SHIP
Mouse, Human
IP, WB
Unconjugated, Azide-free
200µg   $635.00
Select
Rabbit Polyclonal (IgG) to Human INPP5D / SHIP1 / SHIP
Mouse, Rat, Human
ELISA, WB
Unconjugated
50µl   1mg/ml   $235.00; 100µl   1mg/ml   $265.00; 200µl   1mg/ml   $335.00
Select
Rabbit Polyclonal (IgG) to Human INPP5D / SHIP1 / SHIP
Mouse, Rat, Human
ELISA, WB
Unconjugated
100µg   100µl   1µg/µl   $305.00
INPP5D / SHIP1 / SHIP Antibody - Western blot of SHIP-1 antibody
Select
Rabbit Polyclonal (IgG) to Human INPP5D / SHIP1 / SHIP
Mouse, Rat, Human
ELISA, WB
Unconjugated
50µl   1mg/ml   $235.00; 100µl   1mg/ml   $265.00; 200µl   1mg/ml   $335.00
INPP5D / SHIP1 / SHIP Antibody - Western blot analysis of extracts from mouse brain cells, using SHIP1 (Ab-1020) antibody.
Select
Rabbit Polyclonal (IgG) to Human INPP5D / SHIP1 / SHIP
Mouse, Human
ELISA, WB
Unconjugated
100µg   $305.00
INPP5D / SHIP1 / SHIP Antibody - Western blot analysis of extracts from HepG2 cells, treated with TNF (200ng/ml, 30mins), using SHIP1 (Phospho-Tyr1021) antibody.
Select
Rabbit Polyclonal (IgG) to Human INPP5D / SHIP1 / SHIP
Mouse, Human
ELISA, WB
Unconjugated
100µg   $305.00
INPP5D / SHIP1 / SHIP Antibody - Western blot of Phospho-SHIP-1 (Y1021) antibody
Select
Rabbit Polyclonal (IgG) to Human INPP5D / SHIP1 / SHIP
Mouse, Rat, Human
ELISA, WB
Unconjugated
50µl   1mg/ml   $235.00; 100µl   1mg/ml   $265.00; 200µl   1mg/ml   $335.00
Select
Rabbit Polyclonal (IgG) to Mouse INPP5D / SHIP1 / SHIP
Mouse, Rat
IHC
Unconjugated
60µl   430µg/ml   $235.00; 120µl   430µg/ml   $295.00; 200µl   430µg/ml   $395.00

Viewing 1-25 of 40 items


If you do not find the reagent or information you require, please contact customer.support@lsbio.com to inquire about additional products in development.

PLEASE NOTE

For RESEARCH USE ONLY. Not intended for human diagnostic or therapeutic purposes.

The data on this page has been compiled from LifeSpan internal sources, the National Center for Biotechnology Information (NCBI), and The Universal Protein Resource (UniProt).