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Work with LifeSpan to design a custom immunohistochemistry to address your specific biological question. Outsource the entire localization process without having to worry about finding and characterizing target specific antibodies, sourcing and validating difficult-to-find tissues, and having the ability to interpret the resulting immunostaining in relation to complex human pathologies.

Test your therapeutic antibodies in immunohistochemistry against a broad panel of normal frozen human tissue types in order to determine potential unintended binding. Our non-GLP TCR services are designed on the FDA recommendation outlined in their "Points to Consider in the Manufacture and Testing of Monoclonal Antibody Products for Human Use".

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INPP5D / SHIP1 / SHIP

inositol polyphosphate-5-phosphatase, 145kDa

Phosphatidylinositol (PtdIns) phosphatase that specifically hydrolyzes the 5-phosphate of phosphatidylinositol-3,4,5-trisphosphate (PtdIns(3,4,5)P3) to produce PtdIns(3,4)P2, thereby negatively regulating the PI3K (phosphoinositide 3-kinase) pathways. Acts as a negative regulator of B-cell antigen receptor signaling. Mediates signaling from the FC-gamma-RIIB receptor (FCGR2B), playing a central role in terminating signal transduction from activating immune/hematopoietic cell receptor systems. Acts as a negative regulator of myeloid cell proliferation/survival and chemotaxis, mast cell degranulation, immune cells homeostasis, integrin alpha-IIb/beta-3 signaling in platelets and JNK signaling in B-cells. Regulates proliferation of osteoclast precursors, macrophage programming, phagocytosis and activation and is required for endotoxin tolerance. Involved in the control of cell-cell junctions, CD32a signaling in neutrophils and modulation of EGF-induced phospholipase C activity. Key regulator of neutrophil migration, by governing the formation of the leading edge and polarization required for chemotaxis. Modulates FCGR3/CD16-mediated cytotoxicity in NK cells. Mediates the activin/TGF-beta-induced apoptosis through its Smad-dependent expression. May also hydrolyze PtdIns(1,3,4,5)P4, and could thus affect the levels of the higher inositol polyphosphates like InsP6.

Gene Name: inositol polyphosphate-5-phosphatase, 145kDa
Family/Subfamily: Inositol Phosphatase , not assigned-Inositol Phosphatase
Synonyms: INPP5D, p150Ship, SHIP, SHIP1, SHIP-1, Hp51CN, SIP-145
Target Sequences: NM_005541 NP_005532.2 Q92835

Filtered By: None
Target
INPP5D / SHIP1 / SHIP (34)
Reactivity
Human (34)
Mouse (18)
Rat (17)
Bovine (6)
Chimpanzee (3)
Dog (4)
Gibbon (3)
Guinea pig (4)
Horse (4)
Monkey (4)
Application
IHC (5)
IHC-P (4)
WB (32)
Flo (2)
ELISA (11)
IP (1)
Peptide-ELISA (4)
Host
rabbit (25)
mouse (9)
Isotype
IgG (11)
IgG2a (9)
Clonality
monoclonal mc (9)
polyclonal pc (25)
Clone
SHIP-01 (2)
SHIP-02 (1)
Format
AP Conjugated (1)
Azide-free (1)
Biotin Conjugated (2)
FITC Conjugated (2)
HRP Conjugated (2)
PE Conjugated (1)
Unconjugated (26)
Epitope
C-Terminus (8)
N-Terminus (5)
960-1040 aa (2)
pTyr1020 (2)
1110-1190 aa, C-terminal (1)
Met1014 (1)
Pro1167 (1)
aa1140-1189 (1)
aa7-133 (1)
aa770-796 (1)
aa987-1036 (1)
pTyr1021 (1)
Publications
No (34)
Showing 1-25 of 34 results

INPP5D / SHIP1 / SHIP Antibody (N-Terminus, clone SHIP-01) IHC-plus™ LS-B13465
Mouse Monoclonal [clone SHIP-01] (IgG2a) to Human INPP5D / SHIP1 / SHIP
Human
Flo IHC IHC-P WB
Unconjugated
50µg 1mg/ml  $425.00
Human Tonsil: Formalin-Fixed, Paraffin-Embedded (FFPE)
WB using SHIP-1 Antibody (SHIP-01)
Human Tonsil: Formalin-Fixed, Paraffin-Embedded (FFPE)
WB using SHIP-1 Antibody (SHIP-01)

INPP5D / SHIP1 / SHIP Antibody (C-Terminus) IHC-plus™ LS-B5303
Rabbit Polyclonal (IgG) to Human INPP5D / SHIP1 / SHIP
Mouse, Rat, Human
IHC IHC-P
Unconjugated
250µl  $425.00
Anti-INPP5D / SHIP antibody IHC of human tonsil. Immunohistochemistry of formalin-fixed, paraffin-embedded tissue after heat-induced antigen retrieval. Antibody dilution 1:50.
Anti-INPP5D / SHIP antibody IHC of human tonsil. Immunohistochemistry of formalin-fixed, paraffin-embedded tissue after heat-induced antigen retrieval. Antibody dilution 1:50.

INPP5D / SHIP1 / SHIP Antibody (aa1140-1189) IHC-plus™ LS-B11346
Rabbit Polyclonal (IgG) to Human INPP5D / SHIP1 / SHIP
Mouse, Rat, Human
IHC IHC-P Peptide-ELISA WB
Unconjugated
100µl 1mg/ml  $505.00
Anti-INPP5D / SHIP1 / SHIP antibody IHC staining of human thymus. Immunohistochemistry of formalin-fixed, paraffin-embedded tissue after heat-induced antigen retrieval. Antibody dilution 1:50.
Western blot analysis of lysates from HUVEC cells, using SHIP1 Antibody. The lane on the right is blocked with the synthesized peptide.
Anti-INPP5D / SHIP1 / SHIP antibody IHC staining of human thymus. Immunohistochemistry of formalin-fixed, paraffin-embedded tissue after heat-induced antigen retrieval. Antibody dilution 1:50.
Western blot analysis of lysates from HUVEC cells, using SHIP1 Antibody. The lane on the right is blocked with the synthesized peptide.

INPP5D / SHIP1 / SHIP Antibody (C-Terminus) LS-C145498
Rabbit Polyclonal to Human INPP5D / SHIP1 / SHIP
Mouse, Dog, Guinea pig, Bovine, Rat, Horse, Human, Monkey
WB
Unconjugated
50µg  $365.00
INPP5D / SHIP antibody Western blot of 1 Cell lysate. Antibody concentration 1 ug/ml.  This image was taken for the unconjugated form of this product. Other forms have not been tested.
INPP5D / SHIP antibody Western blot of 1 Cell lysate. Antibody concentration 1 ug/ml.  This image was taken for the unconjugated form of this product. Other forms have not been tested.

INPP5D / SHIP1 / SHIP Antibody LS-C662951
Rabbit Polyclonal to Human INPP5D / SHIP1 / SHIP
Human
IHC IHC-P WB
Unconjugated
100µg  $325.00
IHC analysis of SHIP using anti-SHIP antibody
IHC analysis of SHIP using anti-SHIP antibody
IHC analysis of SHIP using anti-SHIP antibody
IHC analysis of SHIP using anti-SHIP antibody

INPP5D / SHIP1 / SHIP Antibody (N-Terminus, clone SHIP-02) LS-C355182
Mouse Monoclonal [clone SHIP-02] (IgG2a) to Human INPP5D / SHIP1 / SHIP
Human
Flo WB
Unconjugated
100µg  $345.00
WB using SHIP-1 Antibody (SHIP-02)
WB using SHIP-1 Antibody (SHIP-02)

INPP5D / SHIP1 / SHIP Antibody (N-Terminus) LS-C145096
Rabbit Polyclonal to Human INPP5D / SHIP1 / SHIP
Human
IHC WB
Unconjugated
100µl  $365.00

INPP5D / SHIP1 / SHIP Antibody (N-Terminus) LS-C132083
Mouse Monoclonal (IgG2a) to Human INPP5D / SHIP1 / SHIP
Human
ELISA WB
Unconjugated
100µg  $475.00

INPP5D / SHIP1 / SHIP Antibody (HRP) LS-C549445
Mouse Monoclonal (IgG2a) to Human INPP5D / SHIP1 / SHIP
Human
ELISA WB
HRP Conjugated
100µl  $650.00

INPP5D / SHIP1 / SHIP Antibody (Biotin) LS-C529356
Mouse Monoclonal (IgG2a) to Human INPP5D / SHIP1 / SHIP
Human
ELISA WB
Biotin Conjugated
100µl  $650.00

INPP5D / SHIP1 / SHIP Antibody (FITC) LS-C539280
Mouse Monoclonal (IgG2a) to Human INPP5D / SHIP1 / SHIP
Human
ELISA WB
FITC Conjugated
100µl  $650.00

INPP5D / SHIP1 / SHIP Antibody (PE) LS-C657425
Mouse Monoclonal (IgG2a) to Human INPP5D / SHIP1 / SHIP
Human
ELISA WB
PE Conjugated
100µl  $650.00

INPP5D / SHIP1 / SHIP Antibody (AP) LS-C511261
Mouse Monoclonal (IgG2a) to Human INPP5D / SHIP1 / SHIP
Human
ELISA WB
AP Conjugated
100µl  $650.00

INPP5D / SHIP1 / SHIP Antibody (N-Terminus, clone SHIP-01) LS-C188431
Mouse Monoclonal [clone SHIP-01] (IgG2a) to Human INPP5D / SHIP1 / SHIP
Human
ELISA WB
Unconjugated
100µg 1mg/ml  $315.00

INPP5D / SHIP1 / SHIP Antibody (phospho-Tyr1020) LS-C291632
Rabbit Polyclonal (IgG) to Human INPP5D / SHIP1 / SHIP
Mouse, Rat, Human
ELISA Peptide-ELISA WB
Unconjugated
50µl 1mg/ml  $265.00; 100µl 1mg/ml  $325.00
Western blot analysis of lysates from HepG2 cells treated with TNF 200NG/ML 30', using SHIP1 (Phospho-Tyr1021) Antibody.
Enzyme-Linked Immunosorbent Assay (Phospho-ELISA) for Immunogen Phosphopeptide (Phospho-left) and Non-Phosphopeptide (Phospho-right), using SHIP1 (Phospho-Tyr1021) Antibody
Western blot analysis of lysates from HepG2 cells treated with TNF 200NG/ML 30', using SHIP1 (Phospho-Tyr1021) Antibody.
Enzyme-Linked Immunosorbent Assay (Phospho-ELISA) for Immunogen Phosphopeptide (Phospho-left) and Non-Phosphopeptide (Phospho-right), using SHIP1 (Phospho-Tyr1021) Antibody

INPP5D / SHIP1 / SHIP Antibody (960-1040 aa) LS-C386057
Rabbit Polyclonal (IgG) to Human INPP5D / SHIP1 / SHIP
Mouse, Rat, Human
ELISA WB
Unconjugated
100µl 1mg/ml  $265.00

INPP5D / SHIP1 / SHIP Antibody (aa7-133, Azide-free) LS-C17828
Rabbit Polyclonal (IgG) to Mouse INPP5D / SHIP1 / SHIP
Mouse, Human
IP WB
Unconjugated, Azide-free
200µg  $635.00

INPP5D / SHIP1 / SHIP Antibody (1110-1190 aa, C-terminal) LS-C386059
Rabbit Polyclonal (IgG) to Human INPP5D / SHIP1 / SHIP
Mouse, Rat, Human
ELISA WB
Unconjugated
100µl 1mg/ml  $265.00
Western blot of SHIP-1 antibody
Western blot of SHIP-1 antibody

INPP5D / SHIP1 / SHIP Antibody (960-1040 aa) LS-C380925
Rabbit Polyclonal (IgG) to Human INPP5D / SHIP1 / SHIP
Mouse, Rat, Human
ELISA WB
Unconjugated
100µl 1mg/ml  $265.00
Western blot of Phospho-SHIP-1 (Y1021) antibody
Western blot of Phospho-SHIP-1 (Y1021) antibody
Western blot of Phospho-SHIP-1 (Y1021) antibody
Western blot of Phospho-SHIP-1 (Y1021) antibody

INPP5D / SHIP1 / SHIP Antibody (aa987-1036) LS-C117781
Rabbit Polyclonal (IgG) to Human INPP5D / SHIP1 / SHIP
Mouse, Rat, Human
Peptide-ELISA WB
Unconjugated
50µl 1mg/ml  $265.00; 100µl 1mg/ml  $325.00
Western blot analysis of lysates from mouse brain, using SHIP1 Antibody. The lane on the right is blocked with the synthesized peptide.
Western blot analysis of lysates from mouse brain, using SHIP1 Antibody. The lane on the right is blocked with the synthesized peptide.

INPP5D / SHIP1 / SHIP Antibody (phospho-Tyr1021) LS-C199568
Rabbit Polyclonal (IgG) to Human INPP5D / SHIP1 / SHIP
Mouse, Rat, Human
Peptide-ELISA WB
Unconjugated
50µl 1mg/ml  $265.00; 100µl 1mg/ml  $325.00
Western blot analysis of lysates from HepG2 cells treated with TNF 200NG/ML 30', using SHIP1 (Phospho-Tyr1021) Antibody. The lane on the right is blocked with the phospho peptide.
Western blot analysis of lysates from HepG2 cells treated with TNF 200NG/ML 30', using SHIP1 (Phospho-Tyr1021) Antibody. The lane on the right is blocked with the phospho peptide.

INPP5D / SHIP1 / SHIP Antibody (phospho-Tyr1020) LS-C750584
Rabbit Polyclonal (IgG) to Human INPP5D / SHIP1 / SHIP
Human
WB
Unconjugated
50µl  $265.00

INPP5D / SHIP1 / SHIP Antibody (Pro1167) LS-C176205
Rabbit Polyclonal to Human INPP5D / SHIP1 / SHIP
Mouse, Rat, Human
WB
Unconjugated
100µl  $345.00
Western blot of SHIP1 (P1167) pAb in extracts from HUVEC cells.
Western blot of SHIP1 (P1167) pAb in extracts from HUVEC cells.

INPP5D / SHIP1 / SHIP Antibody (Met1014) LS-C176469
Rabbit Polyclonal to Human INPP5D / SHIP1 / SHIP
Mouse, Rat, Human
WB
Unconjugated
100µl  $345.00
Western blot of SHIP1 (M1014) pAb in extracts from mouse brain.
Western blot of SHIP1 (M1014) pAb in extracts from mouse brain.

INPP5D / SHIP1 / SHIP Antibody (aa770-796) LS-C97337
Rabbit Polyclonal to Human INPP5D / SHIP1 / SHIP
Human
WB
Unconjugated
400µl  $305.00
Western blot of INPP5D (arrow) using rabbit polyclonal INPP5D Antibody. 293 cell lysates (2 ug/lane) either nontransfected (Lane 1) or transiently transfected with the INPP5D gene (Lane 2) (Origene Technologies).
Western blot of INPP5D (arrow) using rabbit polyclonal INPP5D Antibody. 293 cell lysates (2 ug/lane) either nontransfected (Lane 1) or transiently transfected with the INPP5D gene (Lane 2) (Origene Technologies).
Showing 1-25 of 34 results

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For RESEARCH USE ONLY. Not intended for human diagnostic or therapeutic purposes.

The data on this page has been compiled from LifeSpan internal sources, the National Center for Biotechnology Information (NCBI), and The Universal Protein Resource (UniProt).

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