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IMPDH2
IMP (inosine 5'-monophosphate) dehydrogenase 2
Catalyzes the conversion of inosine 5'-phosphate (IMP) to xanthosine 5'-phosphate (XMP), the first committed and rate-limiting step in the de novo synthesis of guanine nucleotides, and therefore plays an important role in the regulation of cell growth. Could also have a single-stranded nucleic acid-binding activity and could play a role in RNA and/or DNA metabolism. It may also have a role in the development of malignancy and the growth progression of some tumors.
| Gene Name: | IMP (inosine 5'-monophosphate) dehydrogenase 2 |
| Synonyms: | IMPDH2, IMP dehydrogenase 2, IMP oxireductase 2, IMPD2, IMPDH-II, Dna binding protein rfx2, IMPD 2, IMPDH 2 |
| Target Sequences: | NM_000884 NP_000875.2 P12268 |
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