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ILT2 / CD85

leukocyte immunoglobulin-like receptor, subfamily B (with TM and ITIM domains), member 1

Receptor for class I MHC antigens. Recognizes a broad spectrum of HLA-A, HLA-B, HLA-C and HLA-G alleles. Receptor for H301/UL18, a human cytomegalovirus class I MHC homolog. Ligand binding results in inhibitory signals and down-regulation of the immune response. Engagement of LILRB1 present on natural killer cells or T-cells by class I MHC molecules protects the target cells from lysis. Interaction with HLA-B or HLA-E leads to inhibition of the signal triggered by FCER1A and inhibits serotonin release. Inhibits FCGR1A-mediated phosphorylation of cellular proteins and mobilization of intracellular calcium ions.

Gene Name: leukocyte immunoglobulin-like receptor, subfamily B (with TM and ITIM domains), member 1
Synonyms: LILRB1, CD85, CD85j antigen, CD85J, Ig-like transcript 2, Leukocyte Ig-like receptor-1, LIR-1, LIR1, ILT-2, MIR-7, MIR7, ILT2
Target Sequences: Q8NHL6 Q8NHL6

Publications (2)

1
Enhanced Bone Marrow Homing of Natural Killer Cells Following mRNA Transfection With Gain-of-Function Variant CXCR4R334X. Levy E, Reger R, Segerberg F, Lambert M, Leijonhufvud C, Baumer Y, Carlsten M, Childs R. Frontiers in immunology. 2019 June;10: [Full Text Article] [PubMed:31231387] [PMC:PMC6560173]
2
LIR-1 educates expanded human NK cells and defines a unique antitumor NK cell subset with potent antibody-dependent cellular cytotoxicity. Caroline Leijonhufvud, Robert Reger, Filip Segerberg, Jakob Theorell, Heinrich Schlums, Yenan T Bryceson, Richard W Childs, Mattias Carlsten. Clinical & translational immunology. 2021 October;10:e1346. [Full Text Article] [PubMed:34631057] [PMC:PMC8491220] Related Antibodies: LS-C107050.

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ILT2 / CD85 (3)
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ILT2 / CD85 ELISA Kit
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96-Well Strip Plate
Human
31.2 - 2000 pg/ml
Colorimetric - 450nm (TMB)
Plasma, Serum, Tissue Homogenates
1 Plate/$579
ILT2 / CD85 ELISA Kit
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Sandwich
96-Well Strip Plate
Human
31.2 - 2000 pg/ml
Colorimetric - 450nm (TMB)
Plasma, Serum
1 Plate/$669
ILT2 / CD85 ELISA Kit
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Custom
96-Well Microplate
Human
Colorimetric - 450nm (TMB)
1 Plate/$610
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If you do not find the reagent or information you require, please contact Customer.Support@LSBio.com to inquire about additional products in development.

PLEASE NOTE

For RESEARCH USE ONLY. Intended for use by laboratory professionals. Not intended for human diagnostic or therapeutic purposes.

The data on this page has been compiled from LifeSpan internal sources, the National Center for Biotechnology Information (NCBI), and The Universal Protein Resource (UniProt).