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Receptor for class I MHC antigens. Recognizes a broad spectrum of HLA-A, HLA-B, HLA-C and HLA-G alleles. Receptor for H301/UL18, a human cytomegalovirus class I MHC homolog. Ligand binding results in inhibitory signals and down-regulation of the immune response. Engagement of LILRB1 present on natural killer cells or T-cells by class I MHC molecules protects the target cells from lysis. Interaction with HLA-B or HLA-E leads to inhibition of the signal triggered by FCER1A and inhibits serotonin release. Inhibits FCGR1A-mediated phosphorylation of cellular proteins and mobilization of intracellular calcium ions.
Gene Name: | leukocyte immunoglobulin-like receptor, subfamily B (with TM and ITIM domains), member 1 |
Synonyms: | LILRB1, CD85, CD85j antigen, CD85J, Ig-like transcript 2, Leukocyte Ig-like receptor-1, LIR-1, LIR1, ILT-2, MIR-7, MIR7, ILT2 |
Target Sequences: | Q8NHL6 Q8NHL6 |
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