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IL5 is a cytokine that acts as a growth and differentiation factor for both B cells and eosinophils. The encoded cytokine plays a major role in the regulation of eosinophil formation, maturation, recruitment and survival. The increased production of this cytokine may be related to pathogenesis of eosinophil-dependent inflammatory diseases. This cytokine functions by binding to its receptor, which is a heterodimer, whose beta subunit is shared with the receptors for interleukine 3 (IL3) and colony stimulating factor 2 (CSF2/GM-CSF). This gene is located on chromosome 5 within a cytokine gene cluster which includes interleukin 4 (IL4), interleukin 13 (IL13), and CSF2 . This gene, IL4, and IL13 may be regulated coordinately by long-range regulatory elements spread over 120 kilobases on chromosome 5q31.
Gene Name: | interleukin 5 (colony-stimulating factor, eosinophil) |
Family/Subfamily: | Hormone , not assigned-Hormone |
Synonyms: | IL5, EDF, Interleukin-5, IL-5, T-cell replacing factor, TRF |
Target Sequences: | NM_000879 NP_000870.1 P05113 |
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