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IL37

interleukin 37

IL37 is a member of the interleukin 1 cytokine family. This cytokine can bind to, and may be a ligand for interleukin 18 receptor (IL18R1/IL-1Rrp). This cytokine also binds to interleukin 18 binding protein (IL18BP), an inhibitory binding protein of interleukin 18 (IL18), and subsequently forms a complex with IL18 receptor beta subunit, and through which it inhibits the activity of IL18. This gene along with eight other interleukin 1 family genes form a cytokine gene cluster on chromosome 2. Five alternatively spliced transcript variants encoding distinct isoforms have been reported.

Gene Name: interleukin 37
Family/Subfamily: IL-1 , not assigned-IL-1
Synonyms: IL37, FIL1, FIL1 zeta, FIL1(ZETA), IL-1 zeta, IL-1F7, IL-1H, IL-1RP1, IL-1X, IL-37, Interleukin-1 homolog 4, Interleukin-1 zeta, Interleukin-1-related protein, Interleukin-23, Interleukin-37, IL1F7, Interleukin 1, zeta, Interleukin-1 family member 7, FIL1Z, IL-1H4, IL1RP1, Interleukin 1 family member 7, Interleukin 37, IL-1X protein, IL1H4, Interleukin-1 superfamily z
Target Sequences: NM_014439 NP_055254.2 Q9NZH6

Publications (2)

1
miR-31 is a broad regulator of ß1-integrin expression and function in cancer cells. Augoff K, Das M, Bialkowska K, McCue B, Plow EF, Sossey-Alaoui K. Molecular cancer research : MCR. 2011 9:1500-8. (IHC; Human) [Full Text Article] [PubMed:21875932] [PMC:PMC3219821]
2
Tuberculosis-sensitized monocytes sustain immune response of interleukin-37. Zhang JA, Liu GB, Zheng BY, Lu YB, Gao YC, Cai XZ, Dai YC, Yu SY, Jia Y, Chen C, Zhuang ZG, Wang X, Wang WD, Fu XX, Yi LL, Shen L, Chen ZW, Xu JF. Molecular immunology. 2016 November;79:14-21. (Human) [Full Text Article] [PubMed:27689749] [PMC:PMC5760171] Related Antibodies: LS-C133726.

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Antibodies (47)
Primary (47)
IL37 (47)
Human (47)
Mouse (3)
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IHC (9)
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ELISA (13)
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IF (1)
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rabbit (32)
mouse (15)
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Coronavirus Antibodies Proteins cDNAs (45)
Cytokine Release Syndrome Antibodies (45)
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monoclonal mc (15)
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aa27-192 (18)
aa46-218 (8)
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Internal (1)
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aa100-150 (1)
No (46)
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IL37 Antibody - Immunoperoxidase of monoclonal antibody to IL1F7 on formalin-fixed paraffin-embedded human small Intestine. [antibody concentration 3 ug/ml]
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IL37 Mouse anti-Human Monoclonal (6A6) Antibody
Human
ELISA, IHC, IHC-P, WB
Unconjugated
100 µg/$423
IL37 Antibody - Immunohistochemical staining of IL-37 in human rheumatoid arthritis tissue. . Method: Immunohistochemical analysis of a paraffin-embedded rheumatoid arthritis tissue, showing endothelial cells and plasma cells (mature B cells) stained by anti-IL-37 at dilution 1:50 (under X200 lens, Brown color).
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IL37 Rabbit anti-Human Polyclonal Antibody
Human
ELISA, IHC, IHC-P, IP, WB
Unconjugated
100 µg/$407
IL37 Antibody - Anti-IL37 antibody IHC staining of human spleen. Immunohistochemistry of formalin-fixed, paraffin-embedded tissue after heat-induced antigen retrieval. Antibody concentration 10 ug/ml.
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IL37 Rabbit anti-Human Polyclonal Antibody
Human
ELISA, IF, IHC, IHC-P, WB
Unconjugated
50 µg/$460
IL37 Antibody - Western Blot ;Sample: Recombinant IL1z, Human.
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IL37 Mouse anti-Human Monoclonal (aa27-192) Antibody
Human
WB
Unconjugated
100 µl/$292; 200 µl/$327; 500 µl/$443; 1 ml/$501; 2 ml/$626; 5 ml/$1,072
IL37 Antibody - Western Blot ;Sample: Recombinant IL1z, Human.
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IL37 Mouse anti-Human Monoclonal (aa27-192) (APC) Antibody
Human
WB
APC Conjugated
100 µl/$373; 200 µl/$443; 500 µl/$715; 1 ml/$873; 2 ml/$1,124; 5 ml/$2,031
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IL37 Rabbit anti-Human Polyclonal (aa100-150) Antibody
Human
WB
Unconjugated
100 µg/$386
IL37 Antibody - Immunohistochemical analysis of paraffin-embedded human-small-intestine, antibody was diluted at 1:200.
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IL37 Rabbit anti-Human Polyclonal Antibody
Human
ELISA, IHC
Unconjugated
50 µg/$295; 100 µg/$335; 200 µg/$394
IL37 Antibody - Immunohistochemistry of paraffin-embedded Human brain tissue  using IL37 Polyclonal Antibody at dilution of 1:50(×200)
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IL37 Rabbit anti-Human Polyclonal Antibody
Human
ELISA, IHC, WB
Unconjugated
20 µl/$254; 60 µl/$296; 120 µl/$355; 200 µl/$450
IL37 Antibody - Immunohistochemistry of paraffin-embedded human breast cancer using antibody at 1:100 dilution.
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IL37 Rabbit anti-Human Polyclonal (aa1-218) Antibody
Human
ELISA, IHC, IHC-P
Unconjugated
50 µl/$294; 100 µl/$360
IL37 Antibody - Immunohistochemistry of paraffin-embedded Human brain tissue  using IL37 Polyclonal Antibody at dilution of 1:50(×200)
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IL37 Rabbit anti-Human Polyclonal Antibody
Human
ELISA, IHC
Unconjugated
20 µl/$254; 60 µl/$296; 120 µl/$355; 200 µl/$450
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IL37 Mouse anti-Human Monoclonal Antibody
Human
ELISA, WB
Unconjugated
100 µg/$361
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IL37 Mouse anti-Human Monoclonal (aa27-192) (Biotin) Antibody
Human
ICC, WB
Biotin Conjugated
200 µl/$338
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IL37 Mouse anti-Human Monoclonal (aa27-192) (FITC) Antibody
Human
ICC, WB
FITC Conjugated
200 µl/$350
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IL37 Rabbit anti-Human Polyclonal Antibody
Human
ELISA, WB
Unconjugated
100 µg/$341
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IL37 Mouse anti-Human Monoclonal (aa1-219) (Biotin) Antibody
Human
IHC, IHC-P
Biotin Conjugated
100 µl/$904
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IL37 Mouse anti-Human Monoclonal (aa1-219) (Azide-free) Antibody
Human
IHC, IHC-P
Unconjugated, Azide-free
100 µg/$705
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IL37 Rabbit anti-Human Polyclonal Antibody
Human
ELISA, IHC-P
Unconjugated
100 µg/$357
IL37 Antibody - Western blot analysis IL1F7 using HepG2 whole cells lysates
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IL37 Rabbit anti-Human Polyclonal Antibody
Human
Peptide-ELISA, WB
Unconjugated
100 µl/$379; 200 µl/$421
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IL37 Mouse anti-Human Monoclonal (Preservative Free) (20) Antibody
Human
ELISA
Unconjugated, Preservative Free
20 µl/$256; 100 µl/$412
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IL37 Rabbit anti-Human Polyclonal Antibody
Human
ELISA
Unconjugated
100 µl/$412
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IL37 Rabbit anti-Human Polyclonal Antibody
Human
ELISA
Unconjugated
100 µl/$412
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IL37 Rabbit anti-Human Polyclonal Antibody
Mouse, Rat, Human
WB
Unconjugated
50 µl/$321; 100 µl/$403
IL37 Antibody - Western blot of lysate from human brain tissue lysate, using IL37 Antibody (A1-1822). A1-1822 was diluted at 1:500. A goat anti-rabbit IgG H&L (HRP) at 1:10000 dilution was used as the secondary antibody.Lysate at 20 ug.
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IL37 Rabbit anti-Human Polyclonal Antibody
Human
WB
Unconjugated
100 µl/$386
IL37 Antibody - Western blot of recombinant IL37.  This image was taken for the unconjugated form of this product. Other forms have not been tested.
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IL37 Rabbit anti-Human Polyclonal (aa27-192) Antibody
Human
WB
Unconjugated
100 µl/$279; 200 µl/$309; 500 µl/$407; 1 ml/$457; 2 ml/$555; 5 ml/$948
IL37 Antibody - Western blot of recombinant IL37.  This image was taken for the unconjugated form of this product. Other forms have not been tested.
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IL37 Rabbit anti-Human Polyclonal (aa27-192) (Biotin) Antibody
Human
WB
Biotin Conjugated
100 µl/$286; 200 µl/$319; 500 µl/$427; 1 ml/$481; 2 ml/$589; 5 ml/$1,019
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The data on this page has been compiled from LifeSpan internal sources, the National Center for Biotechnology Information (NCBI), and The Universal Protein Resource (UniProt).