Work with LifeSpan to design a custom immunohistochemistry to address your specific biological question. Outsource the entire localization process without having to worry about finding and characterizing target specific antibodies, sourcing and validating difficult-to-find tissues, and having the ability to interpret the resulting immunostaining in relation to complex human pathologies.TCR Screening Services
Test your therapeutic antibodies in immunohistochemistry against a broad panel of normal frozen human tissue types in order to determine potential unintended binding. Our non-GLP TCR services are designed on the FDA recommendation outlined in their "Points to Consider in the Manufacture and Testing of Monoclonal Antibody Products for Human Use".
Inhibits the activity of interleukin-36 (IL36A,IL36B and IL36G) by binding to receptor IL1RL2 and preventing its association with the coreceptor IL1RAP for signaling. Part of the IL-36 signaling system that is thought to be present in epithelial barriers and to take part in local inflammatory response; similar to the IL-1 system with which it shares the coreceptor. Proposed to play a role in skin inflammation. May be involved in the innate immune response to fungal pathogens, such as Aspergillus fumigatus. May activate an anti-inflammatory signaling pathway by recruiting SIGIRR.
|Gene Name:||interleukin 36 receptor antagonist|
|Family/Subfamily:||IL-1 , not assigned-IL-1|
|Synonyms:||IL36RN, FIL1, FIL1D, IL-1 delta, IL-1 related protein 3, IL-1HY1, IL-1RP3, IL-1-related protein 3, IL1F5, IL1RP3, IL1L1, IL36RA, Interleukin-1 delta, Family of interleukin 1-delta, FIL1 delta, IL-1L1, IL-1ra homolog 1, Interleukin-1 family member 5, Interleukin-1-like protein 1, FIL1(DELTA), IL-1F5, IL1HY1, Interleukin-1 HY1, PSORP|
|Target Sequences:||NM_012275 NP_036407.1 Q9UBH0|
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