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May play a role in local mechanisms of mucosal immunity and seems to have a proinflammatory function. May play a role in inflammatory bowel disease. Activates STAT1 and STAT3, MAPK1/3 (ERK1/2), JUN and AKT. Induces expression of SOCS3, TNF-alpha and IL-8, secretion of IL-8 and IL-10 and surface expression of ICAM1. Decreases proliferation of intestinal epithelial cells. Is inhibited by heparin.
Gene Name: | interleukin 26 |
Synonyms: | IL26, AK155, IL-26, Interleukin-26, Interleukin 26, Protein AK155 |
Target Sequences: | NM_018402 NP_060872.1 Q9NPH9 |
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