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IL22RA1 / IL22R
interleukin 22 receptor, alpha 1
A novel cytokine, designated IL-TIF for IL-10 related T cell-derived inducible factor and IL-22, was recently identified. The receptor for IL-22 (IL-22R, also termed CRF2-9 and IL-TIF-R1 chain) is a new member of the class II cytokine receptor family. IL-22R forms a complex with IL-10 receptor b chain and mediates IL-22 signaling. IL-22 and its receptor activate JAK-STAT signaling pathway. IL22R is expressed in normal liver and kidney and their cell lines HepG2 and TK-10. A soluble form of IL-22 receptor, also termed IL-22 binding protein (IL-22BP) and IL-22 receptor-a 2 (IL-22RA2), was identified very recently. IL-22BP prevents binding of IL-22 to the functional cell surface IL-22R complex and neutralizes IL-22 activity. LPS induces IL-22 expression, which indicates the role of IL-22 in inflammatory response.
| Gene Name: | interleukin 22 receptor, alpha 1 |
| Family/Subfamily: | Interleukin |
| Synonyms: | IL22RA1, CRF2-9, IL-22RA1, IL-22 receptor subunit alpha-1, IL22R, IL-22R-alpha-1, ZcytoR11, IL22R1, Interleukin 22 receptor |
| Target Sequences: | NM_021258 NP_067081.2 Q8N6P7 |
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