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IL1RL2

interleukin 1 receptor-like 2

Receptor for interleukin-36 (IL36A, IL36B and IL36G). After binding to interleukin-36 associates with the coreceptor IL1RAP to form the interleukin-36 receptor complex which mediates interleukin-36-dependent activation of NF-kappa-B, MAPK and other pathways (By similarity). The IL-36 signaling system is thought to be present in epithelial barriers and to take part in local inflammatory response; it is similar to the IL-1 system. Seems to be involved in skin inflammatory response by induction of the IL-23/IL-17/IL-22 pathway.

Gene Name: interleukin 1 receptor-like 2
Family/Subfamily: Interleukin
Synonyms: IL1RL2, IL-1Rrp2, IL1R-rp2, IL1RRP2, Interleukin 1 receptor-like 2, Interleukin-1 receptor-like 2, IL-36R
Target Sequences: NM_003854 NP_003845.2 Q9HB29

Publications (1)

1
Interleukin-38 promotes skin tumorigenesis in an IL-1Rrp2-dependent manner. Hong Zhou , Qixiang Zhao , Chengcheng Yue , Jiadong Yu , Huaping Zheng, Jing Hu, Zhonglan Hu, Haozhou Zhang, Xiu Teng, Xiao Liu, Xiaoqiong Wei, Yuxi Zhou, Fanlian Zeng, Yan Hao, Yawen Hu, Xiaoyan Wang, Chen Zhang, Linna Gu, Wenling Wu, Yifan Zhou, Kaijun Cui, Nongyu Huang, Wei Li, Zhen Wang, Jiong Li. EMBO reports. 2022 June;23:e53791. [Full Text Article] [PubMed:35578812] [PMC:PMC9171418] Related Antibodies: LS-B10135.

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Products
Proteins (9)
Recombinant (9)
IL1RL2 (9)
SDS-PAGE (1)
No (9)
6His, C-terminus (3)
6His, N-terminus (1)
Fc, C-terminus (3)
GST, N-terminus (1)
Human IgG Fc, C-terminus (1)
Human (6)
Mouse (3)
E. coli (1)
HEK 293 Cells (1)
Human (2)
Human Cells (2)
Mammalian Cells (2)
Wheat Germ Extract (1)
Purified (1)
Low endotoxin level (7)
Select
HEK 293 Cells
Human IgG Fc, C-terminus
SDS-PAGE
Less than 1.0 EU/µg protein (determined by LAL method).
The recombinant human IL1RL2 consists 559 amino acids and predicts a molecular mass of 63.2 kDa.
100 µg/$403; 1 mg/$2,003
Select
Human Cells
Fc, C-terminus
Less than 1.0 EU/µg protein (determined by LAL method).
63.1kD
10 µg/$277; 50 µg/$395; 500 µg/$1,203; 1 mg/$1,627
IL1RL2 Protein - Recombinant Mouse IL-1 Receptor-Like 2/IL-1RL2/IL-1Rrp2/IL-36R (C-Fc)
Select
Human
Fc, C-terminus
Less than 1.0 EU/µg protein (determined by LAL method).
62.97 kDa
10 µg/$317; 50 µg/$529
IL1RL2 Protein - Recombinant Mouse IL-1 Receptor-Like 2/IL-1RL2/IL-1Rrp2/IL-36R (C-6His)
Select
Human
6His, C-terminus
Less than 1.0 EU/µg protein (determined by LAL method).
36.9 kDa
10 µg/$320; 50 µg/$539
IL1RL2 Protein - 12.5% SDS-PAGE Stained with Coomassie Blue.
Select
Wheat Germ Extract
GST, N-terminus
10 µg/$479; 25 µg/$670
IL1RL2 Protein - (Tris-Glycine gel) Discontinuous SDS-PAGE (reduced) with 5% enrichment gel and 15% separation gel.
Select
E. coli
6His, N-terminus
1 mg/$1,679; 100 µg/$598; 20 µg/$405
Select
Mammalian Cells
Fc, C-terminus
Less than 1.0 EU/µg protein (determined by LAL method).
63.1 kDa
10 µg/$277; 50 µg/$389
Select
Mammalian Cells
6His, C-terminus
Less than 1.0 EU/µg protein (determined by LAL method).
37.0 kDa
10 µg/$288; 50 µg/$436
Select
Human Cells
6His, C-terminus
Less than 1.0 EU/µg protein (determined by LAL method).
37kD
10 µg/$288; 50 µg/$442; 500 µg/$1,585; 1 mg/$2,157
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For RESEARCH USE ONLY. Intended for use by laboratory professionals. Not intended for human diagnostic or therapeutic purposes.

The data on this page has been compiled from LifeSpan internal sources, the National Center for Biotechnology Information (NCBI), and The Universal Protein Resource (UniProt).