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IL1RAPL1 is a member of the interleukin 1 receptor family and is similar to the interleukin 1 accessory proteins. It is most closely related to interleukin 1 receptor accessory protein-like 2 (IL1RAPL2). This gene and IL1RAPL2 are located at a region on chromosome X that is associated with X-linked non-syndromic mental retardation. Deletions and mutations in this gene were found in patients with mental retardation. This gene is expressed at a high level in post-natal brain structures involved in the hippocampal memory system, which suggests a specialized role in the physiological processes underlying memory and learning abilities.
Gene Name: | Interleukin 1 Receptor Accessory Protein-like 1 |
Family/Subfamily: | Interleukin |
Synonyms: | IL1RAPL1, IL1RAPL, Interleukin 1 receptor-8, MRX10, MRX34, Oligophrenin-4, IL-1-RAPL-1, IL-1RAPL-1, IL1R8, TIGIRR-2, MRX21, IL1RAPL-1, OPHN4 |
Target Sequences: | NM_014271 NP_055086.1 Q9NZN1 |
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