IL1RAP

interleukin 1 receptor accessory protein

Coreceptor for IL1RL2 in the IL-36 signaling system (By similarity). Coreceptor with IL1R1 in the IL-1 signaling system. Associates with IL1R1 bound to IL1B to form the high affinity interleukin-1 receptor complex which mediates interleukin-1-dependent activation of NF-kappa-B and other pathways. Signaling involves the recruitment of adapter molecules such as TOLLIP, MYD88, and IRAK1 or IRAK2 via the respective TIR domains of the receptor/coreceptor subunits. Recruits TOLLIP to the signaling complex. Does not bind to interleukin-1 alone; binding of IL1RN to IL1R1, prevents its association with IL1R1 to form a signaling complex. The cellular response is modulated through a non-signaling association with the membrane IL1R2 decoy receptor. Secreted forms (isoforms 2 and 3) associate with secreted ligand-bound IL1R2 and increase the affinity of secreted IL1R2 for IL1B; this complex formation may be the dominant mechanism for neutralization of IL1B by secreted/soluble receptors.

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Products

ELISA Kits (5)

Type

Sandwich (3)

Sandwich CLIA (2)

Target

IL1RAP (5)

Reactivity

Human (3)

Mouse (2)

Format

96-Well Strip Plate (4)

Publications

No (5)

Sample Type

Cell Culture Supernatants (1)

EDTA Plasma (1)

Heparin Plasma (1)

Plasma (4)

Serum (5)

Tissue Homogenates (2)

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Human IL1RAP (Sandwich ELISA) ELISA Kit - LS-F6689

Type:

Sandwich

Format:

96-Well Strip Plate

Reactivity:

Human

Range:

0.156 - 10 ng/ml

Detection:

Colorimetric - 450nm (TMB)

Sample Types:

Plasma, Serum, Tissue Homogenates

Price:

1 Plate/$834

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Mouse IL1RAP (Sandwich ELISA) ELISA Kit - LS-F6942

Type:

Sandwich

Format:

96-Well Strip Plate

Reactivity:

Mouse

Range:

31.25 - 2000 pg/ml

Detection:

Colorimetric - 450nm (TMB)

Sample Types:

Plasma, Serum, Tissue Homogenates

Price:

1 Plate/$854

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Mouse IL1RAP (CLIA) ELISA Kit - LS-F26231

Type:

Sandwich CLIA

Format:

96-Well Strip Plate

Reactivity:

Mouse

Range:

2.74 - 2000 pg/ml

Detection:

Chemiluminescent

Sample Types:

Plasma, Serum

Price:

1 Plate/$990

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Human IL1RAP (CLIA) ELISA Kit - LS-F26230

Type:

Sandwich CLIA

Format:

96-Well Strip Plate

Reactivity:

Human

Range:

8.23 - 6000 pg/ml

Detection:

Chemiluminescent

Sample Types:

Plasma, Serum

Price:

1 Plate/$968

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Human IL1RAP (Sandwich ELISA) ELISA Kit - LS-F57303

Type:

Sandwich

Reactivity:

Human

Range:

312 - 20000 pg/ml

Sample Types:

Cell Culture Supernatants, EDTA Plasma, Heparin Plasma, Serum

Price:

1 Plate/$795

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