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IL1R1

interleukin 1 receptor, type I

Receptor for IL1A, IL1B and IL1RN. After binding to interleukin-1 associates with the corecptor IL1RAP to form the high affinity interleukin-1 receptor complex which mediates interleukin-1-dependent activation of NF-kappa-B, MAPK and other pathways. Signaling involves the recruitment of adapter molecules such as TOLLIP, MYD88, and IRAK1 or IRAK2 via the respective TIR domains of the receptor/coreceptor subunits. Binds ligands with comparable affinity and binding of antagonist IL1RN prevents association with IL1RAP to form a signaling complex.

Gene Name: interleukin 1 receptor, type I
Family/Subfamily: Interleukin
Synonyms: IL1R1, Antigen CD121a, D2S1473, IL-1R-1, IL-1R-alpha, IL-1RT-1, IL-1RT1, IL1R, IL1RA, IL1RT1, Interleukin receptor 1, Interleukin-1 receptor alpha, Interleukin-1 receptor type 1, CD121A, CD121a antigen, Interleukin 1 receptor, type I, Interleukin-1 receptor type I, Interleukin-1 type i receptor, p80
Target Sequences: NM_000877 NP_000868.1 P14778

Publications (2)

1
IL-6 and IL-1 synergistically enhanced the production of MMPs from synovial cells by up-regulating IL-6 production and IL-1 receptor I expression. Suzuki M, Hashizume M, Yoshida H, Shiina M, Mihara M. Cytokine. 2010 51:178-83. (WB) [PubMed:20403707]
2
The role of interleukin-1ß in human trophoblast motility. Prutsch N, Fock V, Haslinger P, Haider S, Fiala C, Pollheimer J, Knöfler M. Placenta. 2012 33:696-703. (ELISA; Human) [Full Text Article] [PubMed:22710193] Related Antibodies: LS-B2859.

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IL1R1 (24)
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Coronavirus Detection (23)
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IL1R1 ELISA Kit
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Sandwich
96-Well Microplate
Human
125 - 8000 pg/ml
Colorimetric - 450nm (TMB)
Cell Culture Supernatants, Serum
1 Plate/$795
IL1R1 ELISA Kit
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Sandwich
96-Well Strip Plate
Mouse
93.75 - 6000 pg/ml
Colorimetric - 450nm (TMB)
Plasma, Serum, Tissue Homogenates
1 Plate/$768
IL1R1 ELISA Kit
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Sandwich
96-Well Microplate
Human
0.16 - 10 ng/ml
Colorimetric - 450nm (TMB)
Plasma, Serum
1 Plate/$651
IL1R1 ELISA Kit
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Sandwich
12 x 8-Well Microstrips
Human
125 - 8000 pg/ml
Colorimetric - 450nm (TMB)
Cell Lysates, Plasma, Serum
1 Plate/$618
IL1R1 ELISA Kit
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Sandwich
96-Well Strip Plate
Monkey
0.156 - 10 ng/ml
Colorimetric - 450nm (TMB)
1 Plate/$728
IL1R1 ELISA Kit
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Sandwich
96-Well Strip Plate
Human
0.156 - 10 ng/ml
Colorimetric - 450nm (TMB)
Plasma, Serum, Tissue Homogenates
1 Plate/$579
IL1R1 ELISA Kit
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Sandwich CLIA
12 x 8-Well Microstrips
Human
15.625 - 1000 pg/ml
Chemiluminescent
Plasma, Serum
1 Plate/$728
IL1R1 ELISA Kit
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Sandwich CLIA
12 x 8-Well Microstrips
Human
31.25 - 2000 pg/ml
Chemiluminescent
Plasma, Serum
1 Plate/$728
IL1R1 ELISA Kit
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Sandwich CLIA
12 x 8-Well Microstrips
Mouse
31.25 - 2000 pg/ml
Chemiluminescent
Plasma, Serum
1 Plate/$728
IL1R1 ELISA Kit
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Sandwich CLIA
12 x 8-Well Microstrips
Mouse
12.5 - 800 pg/ml
Chemiluminescent
Plasma, Serum
1 Plate/$728
IL1R1 ELISA Kit
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Custom
96-Well Strip Plate
Mouse
Colorimetric - 450nm (TMB)
1 Plate/$685
IL1R1 ELISA Kit
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Custom
96-Well Strip Plate
Rat
Colorimetric - 450nm (TMB)
1 Plate/$783
IL1R1 ELISA Kit
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Sandwich CLIA
96-Well Strip Plate
Human
31 - 2000 pg/ml
Chemiluminescent
Cell Lysates, Plasma, Serum
1 Plate/$649
IL1R1 ELISA Kit
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Development Kit
1000 Wells
Human
23 - 1500 pg/ml
Colorimetric - 405nm (ABTS)
1 Test/$540
IL1R1 ELISA Kit
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Sandwich
96-Well Strip Plate
Human
125 - 8000 pg/ml
Colorimetric - 450nm (TMB)
Cell Culture Supernatants, Serum
1 Plate/$717
IL1R1 ELISA Kit
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Sandwich
96-Well Microplate
Rat
78.125 - 5000 pg/ml
Colorimetric - 450nm (TMB)
Plasma, Serum
1 Plate/$651
IL1R1 ELISA Kit
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Sandwich
96-Well Microplate
Mouse
93.75 - 6000 pg/ml
Colorimetric - 450nm (TMB)
Plasma, Serum
1 Plate/$651
IL1R1 ELISA Kit
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Sandwich
96-Well Strip Plate
Mouse
0.156 - 10 ng/ml
Colorimetric - 450nm (TMB)
Cell Supernatant, Plasma, Serum
1 Plate/$598
IL1R1 ELISA Kit
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Sandwich
96-Well Strip Plate
Human
0.156 - 10 ng/ml
Colorimetric - 450nm (TMB)
Plasma, Serum
1 Plate/$870
IL1R1 ELISA Kit
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Development Kit
Antibody Pair and Standard
Mouse
62.5 - 4000 pg/ml
Colorimetric - 450nm (TMB)
Plasma, Serum, Tissue Homogenates
500 Wells/$1,207; 1000 Wells/$1,787
IL1R1 ELISA Kit
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Sandwich
96-Well Strip Plate
Human
0.156 - 10 ng/ml
Colorimetric - 450nm (TMB)
Plasma, Serum, Tissue Homogenates
1 Plate/$764
IL1R1 ELISA Kit
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Sandwich
96-Well Strip Plate
Mouse
31.25 - 2000 pg/ml
Colorimetric - 450nm (TMB)
Plasma, Serum, Tissue Homogenates
1 Plate/$782
IL1R1 ELISA Kit
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Sandwich
96-Well Microplate
Human
8.192 - 800 pg/ml
Colorimetric - 450nm (TMB)
Cell Culture Supernatants, Plasma, Serum
1 Plate/$588
IL1R1 ELISA Kit
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Sandwich
96-Well Strip Plate
Human
0.156 - 10 ng/ml
Colorimetric - 450nm (TMB)
Plasma, Serum
1 Plate/$685
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The data on this page has been compiled from LifeSpan internal sources, the National Center for Biotechnology Information (NCBI), and The Universal Protein Resource (UniProt).