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IL17RC

interleukin 17 receptor C

IL17RC encodes a single-pass type I membrane protein that shares similarity with the interleukin-17 receptor (IL-17RA). Unlike IL-17RA, which is predominantly expressed in hemopoietic cells, and binds with high affinity to only IL-17A, this protein is expressed in nonhemopoietic tissues, and binds both IL-17A and IL-17F with similar affinities. The proinflammatory cytokines, IL-17A and IL-17F, have been implicated in the progression of inflammatory and autoimmune diseases. Multiple alternatively spliced transcript variants encoding different isoforms have been detected for this gene, and it has been proposed that soluble, secreted proteins lacking transmembrane and intracellular domains may function as extracellular antagonists to cytokine signaling.

Gene Name: interleukin 17 receptor C
Family/Subfamily: Interleukin
Synonyms: IL17RC, IL-17 receptor C, IL-17RC, IL-17RL, IL17Rhom, IL17RL, IL17-RL, IL17F receptor, Interleukin-17 receptor C, Interleukin 17 receptor C, ZcytoR14
Target Sequences: NM_032732 NP_116121.2 Q8NAC3

Publications (2)

1
Second-Strand Synthesis-Based Massively Parallel scRNA-Seq Reveals Cellular States and Molecular Features of Human Inflammatory Skin Pathologies. Travis K Hughes, Marc H Wadsworth nd, Todd M Gierahn, Tran Do, David Weiss, Priscila R Andrade, Feiyang Ma, Bruno J de Andrade Silva, Shuai Shao, Lam C Tsoi, Jose Ordovas-Montanes, Johann E Gudjonsson, Robert L Modlin, J Christopher Love, Alex K Shalek. Immunity. 2020 October;53:878-894.e7. [Full Text Article] [PubMed:33053333] [PMC:PMC7562821]
2
Gardenia Jasminoides Ameliorates Antibiotic-Associated Aggravation of DNCB-Induced Atopic Dermatitis by Restoring the Intestinal Microbiome Profile. Hyo In Kim, Se Hyang Hong, Seo Yeon Lee, Jin Mo Ku, Min Jeong Kim, Seong-Gyu Ko. Nutrients. 2021 Apr;13:1349. [Full Text Article] [PubMed:33919521] [PMC:PMC8072552] Related Antibodies: LS-C294856.

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Products
Proteins (14)
Over-Expression Lysate (7)
Recombinant (7)
IL17RC (14)
No (14)
Fc (1)
GST (1)
His (1)
His, N-Terminal (1)
His,C-terminus (1)
His-T7 (1)
Myc-DDK (Flag) (8)
Human (10)
Mouse (1)
293T Cells (4)
E. coli (3)
HEK 293 Cells (4)
Human Cells (1)
Insect Cells (1)
Wheat Germ Extract (1)
Purified (3)
Low endotoxin level (2)
IL17RC Protein - Active Interleukin 17 Receptor C (IL17RC) by WB
Select
E. coli
His, N-Terminal
26kDa
10 µg/$339; 50 µg/$802; 200 µg/$1,430; 100 µg/$1,214; 1 mg/$2,728; 500 µg/$2,223; 5 mg/$5,601; 2 mg/$2,988
IL17RC Protein - Western validation with an anti-DDK antibody * L: Control HEK293 lysate R: Over-expression lysate
Select
HEK 293 Cells
Myc-DDK (Flag)
76.4 kDa
100 µg/$710
IL17RC Protein - Western validation with an anti-DDK antibody * L: Control HEK293 lysate R: Over-expression lysate
Select
HEK 293 Cells
Myc-DDK (Flag)
83.9 kDa
100 µg/$710
IL17RC Protein - Western validation with an anti-DDK antibody * L: Control HEK293 lysate R: Over-expression lysate
Select
HEK 293 Cells
Myc-DDK (Flag)
74.6 kDa
100 µg/$710
Select
Insect Cells
His,C-terminus
Less than 1.0 EU/µg protein (determined by LAL method).
49.6 kDa
100 µg/$721
IL17RC Protein - Western validation with an anti-DDK antibody * L: Control HEK293 lysate R: Over-expression lysate
Select
293T Cells
Myc-DDK (Flag)
74.6 kDa
20 µg/$215
Select
293T Cells
Myc-DDK (Flag)
76.4 kDa
20 µg/$215
IL17RC Protein - Western validation with an anti-DDK antibody * L: Control HEK293 lysate R: Over-expression lysate
Select
293T Cells
Myc-DDK (Flag)
76.4 kDa
20 µg/$215
IL17RC Protein - Western validation with an anti-DDK antibody * L: Control HEK293 lysate R: Over-expression lysate
Select
293T Cells
Myc-DDK (Flag)
83.9 kDa
20 µg/$215
IL17RC Protein - Recombinant  Interleukin 17 Receptor C By SDS-PAGE
Select
E. coli
His-T7
28.6 kDa
10 µg/$278; 50 µg/$422; 100 µg/$672; 200 µg/$842; 1 mg/$1,934; 500 µg/$1,480; 5 mg/$2,941; 2 mg/$2,119
IL17RC Protein - 12.5% SDS-PAGE of human IL17RC stained with Coomassie Blue
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Wheat Germ Extract
GST
85.5 kDa
2 µg/$439
IL17RC Protein - Purified recombinant protein IL17RC was analyzed by SDS-PAGE gel and Coomassie Blue Staining
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HEK 293 Cells
Myc-DDK (Flag)
83.9 kDa
20 µg/$1,107
Select
Human Cells
Fc
Less than 1.0 EU/µg protein (determined by LAL method).
75.3 kDa
100 µg/$721
IL17RC Protein - Recombinant Interleukin 17 Receptor C By SDS-PAGE
Select
E. coli
His
30.1 kDa
10 µg/$282; 50 µg/$450; 100 µg/$717; 200 µg/$897; 1 mg/$2,010; 500 µg/$1,547; 5 mg/$3,137; 2 mg/$2,198
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For RESEARCH USE ONLY. Intended for use by laboratory professionals. Not intended for human diagnostic or therapeutic purposes.

The data on this page has been compiled from LifeSpan internal sources, the National Center for Biotechnology Information (NCBI), and The Universal Protein Resource (UniProt).