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B001/B101
Shirley, MA 01464
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Floor 6, Suite 620
20700 44th Avenue W
Lynnwood, WA 98036
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IL17RC
interleukin 17 receptor C
IL17RC encodes a single-pass type I membrane protein that shares similarity with the interleukin-17 receptor (IL-17RA). Unlike IL-17RA, which is predominantly expressed in hemopoietic cells, and binds with high affinity to only IL-17A, this protein is expressed in nonhemopoietic tissues, and binds both IL-17A and IL-17F with similar affinities. The proinflammatory cytokines, IL-17A and IL-17F, have been implicated in the progression of inflammatory and autoimmune diseases. Multiple alternatively spliced transcript variants encoding different isoforms have been detected for this gene, and it has been proposed that soluble, secreted proteins lacking transmembrane and intracellular domains may function as extracellular antagonists to cytokine signaling.
| Gene Name: | interleukin 17 receptor C |
| Family/Subfamily: | Interleukin |
| Synonyms: | IL17RC, IL-17 receptor C, IL-17RC, IL-17RL, IL17Rhom, IL17RL, IL17-RL, IL17F receptor, Interleukin-17 receptor C, Interleukin 17 receptor C, ZcytoR14 |
| Target Sequences: | NM_032732 NP_116121.2 Q8NAC3 |
Publications (2)
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