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IL17A
interleukin 17A
IL17A is a proinflammatory cytokine produced by activated T cells. This cytokine regulates the activities of NF-kappaB and mitogen-activated protein kinases. This cytokine can stimulate the expression of IL6 and cyclooxygenase-2 (PTGS2/COX-2), as well as enhance the production of nitric oxide (NO). High levels of this cytokine are associated with several chronic inflammatory diseases including rheumatoid arthritis, psoriasis and multiple sclerosis.
| Gene Name: | interleukin 17A |
| Family/Subfamily: | Interleukin |
| Synonyms: | IL17A, CTLA-8, CTLA8, Interleukin-17A, Interleukin 17A, IL-17, IL-17A, IL17 |
| Target Sequences: | NM_002190 NP_002181.1 Q16552 |
Publications (3)
1
Bilberry-Derived Anthocyanins Modulate Cytokine Expression in the Intestine of Patients with Ulcerative Colitis. Roth S, Spalinger MR, Gottier C, Biedermann L, Zeitz J, Lang S, Weber A, Rogler G, Scharl M. PloS one. 2016 11:e0154817. (IHC; Human)
[Full Text Article]
[PubMed:27152519]
[PMC:PMC4859486]
Related Antibodies: LS-B8323.
2
Peripheral host T cells survive hematopoietic stem cell transplantation and promote graft-versus-host disease. Sherrie J Divito, Anders T Aasebø, Tiago R Matos, Pei-Chen Hsieh, Matthew Collin, Christopher P Elco, John T O'Malley, Espen S Bækkevold, Henrik Reims, Tobias Gedde-Dahl, Michael Hagerstrom, Jude Hilaire, John W Lian, Edgar L Milford, Geraldine S Pinkus, Vincent T Ho, Robert J Soiffer, Haesook T Kim, Martin C Mihm, Jerome Ritz, Indira Guleria, Corey S Cutler, Rachael A Clark, Frode L Jahnsen, Thomas S Kupper. The Journal of clinical investigation. 2020 September;130:4624-4636. [Full Text Article]
[PubMed:32516138]
[PMC:PMC7456221]
Related Antibodies: LS-C104427.
3
Siramesine causes preferential apoptosis of mast cells in skin biopsies from psoriatic lesions. E Hagforsen, M Lampinen, A Paivandy, S Weström, H Velin, S Öberg, G Pejler, O Rollman. The British journal of dermatology. 2017 July;177:179-187. [Full Text Article]
[PubMed:28117878]
Related Antibodies: LS-B7397.
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Hamster
31.25 - 2000 pg/ml
Colorimetric - 450nm (TMB)
Plasma, Serum, Tissue Homogenates
1 Plate/$768
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96-Well Strip Plate
Mouse
7.8 - 500 pg/ml
Colorimetric - 450nm (TMB)
Cell Culture Supernatants, Plasma, Serum, Tissue Homogenates
1 Plate/$669
Sandwich
96-Well Strip Plate
Rat
15.6 - 1000 pg/ml
Colorimetric - 450nm (TMB)
Plasma, Serum
1 Plate/$685
Sandwich
96-Well Microplate
Human
31.2 - 2000 pg/ml
Colorimetric - 450nm (TMB)
Cell Culture Supernatants, Plasma, Serum
1 Plate/$795
Sandwich
96-Well Strip Plate
Guinea pig
31.25 - 2000 pg/ml
Colorimetric - 450nm (TMB)
Plasma, Serum, Tissue Homogenates
1 Plate/$579
Sandwich
96-Well Strip Plate
Rat
15.63 - 1000 pg/ml
Colorimetric - 450nm (TMB)
Cell Culture Supernatants, Cell Lysates, Plasma, Serum, Tissue Homogenates
1 Plate/$818
Sandwich
12 x 8-Well Microstrips
Human
8 - 2000 pg/ml
Colorimetric - 450nm (TMB)
Cell Lysates, Plasma, Serum
1 Plate/$479
Sandwich
96-Well Strip Plate
Human
15.6 - 1000 pg/ml
Colorimetric - 450nm (TMB)
Cell Culture Supernatants, Plasma, Serum, Tissue Homogenates
1 Plate/$669
Sandwich
96-Well Strip Plate
Mouse
7.8 - 500 pg/ml
Colorimetric - 450nm (TMB)
Cell Culture Supernatants, Plasma, Serum, Tissue Homogenates
1 Plate/$669
Development Kit
Antibody Pair and Standard
Human
31.2 - 2000 pg/ml
Colorimetric - 450nm (TMB)
Cell Culture Supernatants, Cell Lysates, Plasma, Serum, Tissue Homogenates
500 Wells/$1,041; 1000 Wells/$1,512
Sandwich
96-Well Strip Plate
Bovine
15.625 - 1000 pg/ml
Colorimetric - 450nm (TMB)
Plasma, Serum, Tissue Homogenates
1 Plate/$579
Custom
96-Well Strip Plate
Pig
Colorimetric - 450nm (TMB)
1 Plate/$783
Custom
96-Well Strip Plate
Mouse
Colorimetric - 450nm (TMB)
1 Plate/$685
Sandwich CLIA
96-Well Strip Plate
Human
8 - 500 pg/ml
Chemiluminescent
Cell Lysates, Plasma, Serum
1 Plate/$649
Sandwich
96-Well Strip Plate
Mouse
10 - 250 pg/ml
Colorimetric - 450nm (TMB)
Plasma, Serum
1 Plate/$913
Competitive EIA
96-Well Strip Plate
Human
50 - 1000 pg/ml
Colorimetric - 450nm (TMB)
Plasma, Serum
1 Plate/$913
Development Kit
1000 Wells
Human
16 - 1000 pg/ml
Colorimetric - 405nm (ABTS)
1 Test/$540
Development Kit
200 Wells
Human
16 - 1000 pg/ml
Colorimetric - 405nm (ABTS)
1 Test/$180
Sandwich
96-Well Microplate
Mouse
15.6 - 1000 pg/ml
Colorimetric - 450nm (TMB)
Cell Culture Supernatants, Plasma, Serum
1 Plate/$795
Sandwich
96-Well Strip Plate
Sheep
15.63 - 1000 pg/ml
Colorimetric - 450nm (TMB)
Cell Culture Supernatants, Cell Lysates, Plasma, Serum, Tissue Homogenates
1 Plate/$940
Sandwich
96-Well Strip Plate
Human
31.2 - 2000 pg/ml
Colorimetric - 450nm (TMB)
Cell Culture Supernatants, Plasma, Serum, Tissue Homogenates
1 Plate/$669
Sandwich
96-Well Strip Plate
Human
15.625 - 1000 pg/ml
Colorimetric - 450nm (TMB)
Cell Culture Supernatants, Plasma, Serum, Tissue Homogenates
1 Plate/$669
Sandwich
96-Well Strip Plate
Mouse
15.6 - 1000 pg/ml
Colorimetric - 450nm (TMB)
Cell Culture Supernatants, Plasma, Serum, Tissue Homogenates
1 Plate/$669
Sandwich CLIA
96-Well Strip Plate
Human
2.74 - 2000 pg/ml
Chemiluminescent
Plasma, Serum
1 Plate/$968
Sandwich
96-Well Strip Plate
Rat
5 - 100 pg/ml
Colorimetric - 450nm (TMB)
Plasma, Serum
1 Plate/$913
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