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IL12RB1 / CD212

interleukin 12 receptor, beta 1

IL12RB1 / CD212 is a type I transmembrane protein that belongs to the hemopoietin receptor superfamily. This protein binds to interleukine 12 (IL12) with a low affinity, and is thought to be a part of IL12 receptor complex. This protein forms a disulfide-linked oligomer, which is required for its IL12 binding activity. The coexpression of this and IL12RB2 proteins was shown to lead to the formation of high-affinity IL12 binding sites and reconstitution of IL12 dependent signaling. Mutations in this gene impair the development of interleukin-17-producing T lymphocytes and result in increased susceptibility to mycobacterial and Salmonella infections. Alternative splicing results in multiple transcript variants.

Gene Name: interleukin 12 receptor, beta 1
Family/Subfamily: Interleukin
Synonyms: IL12RB1, CD212, IL-12R subunit beta-1, IL-12R-beta-1, IL12R, Interleukin-12 receptor, IL-12 receptor subunit beta-1, IL-12R-BETA1, IL-12RB1, CD212 antigen, IL-12 receptor beta component, IL12RB
Target Sequences: NM_005535 NP_005526.1 P42701

☰ Filters
Products
Proteins (17)
Over-Expression Lysate (4)
Recombinant (13)
IL12RB1 / CD212 (17)
Bind (1)
ELISA (1)
Func (1)
SDS-PAGE (1)
No (17)
6His, C-terminus (1)
Fc, C-terminus (2)
GST (1)
GST, N-terminus + His, C-terminus (1)
His (5)
His,C-terminus (1)
His-GST-S (1)
Myc-DDK (Flag) (5)
Human (14)
Mouse (1)
293T Cells (2)
E. coli (5)
HEK 293 Cells (4)
Human (1)
Human Cells (2)
Insect Cells (1)
Mammalian Cells (1)
Wheat Germ Extract (1)
Purified (4)
Low endotoxin level (6)
Biologically active (1)
IL12RB1 / CD212 Protein
Select
E. coli
His
50 µg/$411; 250 µg/$985; 10 µg/$276
IL12RB1 / CD212 Protein - Measured by its binding ability in a functional ELISA. Immobilized human IL12RB1 at 20 µg/ml (100 µl/well) can bind human IL12B with a linear ranger of 2.56-64 ng/ml.
Select
HEK 293 Cells
His,C-terminus
Bind ELISA Func SDS-PAGE
Biologically active
Less than 1.0 EU/µg protein (determined by LAL method).
The recombinant human IL12RB1 consists of 528 amino acids and predictes a molecular mass of 58.5 kDa. In SDS-PAGE under reducing conditions, the apparent molecular mass of rhIL12RB1 is approximately 70 kDa due to glycosylation.
100 µg/$379; 1 mg/$1,952
IL12RB1 / CD212 Protein - Recombinant  Interleukin 12 Receptor Beta 1 By SDS-PAGE
Select
E. coli
His-GST-S
46.5 kDa
10 µg/$290; 50 µg/$500; 100 µg/$797; 200 µg/$997; 1 mg/$2,139; 500 µg/$1,662; 5 mg/$3,487; 2 mg/$2,329
IL12RB1 / CD212 Protein
Select
Insect Cells
His
Less than 1.0 EU/µg protein (determined by LAL method).
50 µg/$361; 250 µg/$985; 10 µg/$261
Select
Human Cells
His
Less than 1.0 EU/µg protein (determined by LAL method).
58.5 kDa
100 µg/$483
IL12RB1 / CD212 Protein - Western validation with an anti-DDK antibody * L: Control HEK293 lysate R: Over-expression lysate
Select
HEK 293 Cells
Myc-DDK (Flag)
73.14 kDa
100 µg/$710
IL12RB1 / CD212 Protein
Select
E. coli
GST, N-terminus + His, C-terminus
67.6 kDa
50 µg/$419
Select
Human
6His, C-terminus
Less than 1.0 EU/µg protein (determined by LAL method).
58.1 kDa
10 µg/$265; 50 µg/$373
IL12RB1 / CD212 Protein - 12.5% SDS-PAGE of human IL12RB1 stained with Coomassie Blue
Select
Wheat Germ Extract
GST
67.65 kDa
10 µg/$479; 25 µg/$670
IL12RB1 / CD212 Protein - Purified recombinant protein IL12RB1 was analyzed by SDS-PAGE gel and Coomassie Blue Staining
Select
HEK 293 Cells
Myc-DDK (Flag)
70.4 kDa
20 µg/$1,107
IL12RB1 / CD212 Protein - Western validation with an anti-DDK antibody * L: Control HEK293 lysate R: Over-expression lysate
Select
293T Cells
Myc-DDK (Flag)
39.6 kDa
20 µg/$150
IL12RB1 / CD212 Protein - Western validation with an anti-DDK antibody * L: Control HEK293 lysate R: Over-expression lysate
Select
293T Cells
Myc-DDK (Flag)
73.14 kDa
20 µg/$215
IL12RB1 / CD212 Protein - Western validation with an anti-DDK antibody * L: Control HEK293 lysate R: Over-expression lysate
Select
HEK 293 Cells
Myc-DDK (Flag)
39.6 kDa
100 µg/$494
Select
Mammalian Cells
Fc, C-terminus
Less than 1.0 EU/µg protein (determined by LAL method).
84.2 kDa
10 µg/$255; 50 µg/$339
Select
E. coli
His
23.4 kDa
10 µg/$289; 50 µg/$492; 100 µg/$785; 200 µg/$982; 1 mg/$2,119; 500 µg/$1,646; 5 mg/$3,431; 2 mg/$2,309
IL12RB1 / CD212 Protein - Recombinant Interleukin 12 Receptor Beta 1 By SDS-PAGE
Select
E. coli
His
20.6 kDa
10 µg/$289; 50 µg/$492; 100 µg/$785; 200 µg/$982; 1 mg/$2,119; 500 µg/$1,646; 5 mg/$3,431; 2 mg/$2,309
Select
Human Cells
Fc, C-terminus
Less than 1.0 EU/µg protein (determined by LAL method).
84.2kD
10 µg/$255; 50 µg/$343; 500 µg/$1,585; 1 mg/$2,157
Viewing 1-17 of 17 product results


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For RESEARCH USE ONLY. Intended for use by laboratory professionals. Not intended for human diagnostic or therapeutic purposes.

The data on this page has been compiled from LifeSpan internal sources, the National Center for Biotechnology Information (NCBI), and The Universal Protein Resource (UniProt).