IL12B / IL12 p40

interleukin 12B (natural killer cell stimulatory factor 2, cytotoxic lymphocyte maturation factor 2, p40)

IL12B / IL12 p40 is a subunit of interleukin 12, a cytokine that acts on T and natural killer cells, and has a broad array of biological activities. Interleukin 12 is a disulfide-linked heterodimer composed of the 40 kD cytokine receptor like subunit encoded by this gene, and a 35 kD subunit encoded by IL12A. This cytokine is expressed by activated macrophages that serve as an essential inducer of Th1 cells development. This cytokine has been found to be important for sustaining a sufficient number of memory/effector Th1 cells to mediate long-term protection to an intracellular pathogen. Overexpression of this gene was observed in the central nervous system of patients with multiple sclerosis (MS), suggesting a role of this cytokine in the pathogenesis of the disease. The promoter polymorphism of this gene has been reported to be associated with the severity of atopic and non-atopic asthma in children.

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Products

Proteins (23)

Type

Over-Expression Cell Culture Supernatant (1)

Over-Expression Lysate (3)

Recombinant (19)

Target

IL12B / IL12 p40 (23)

Publications

No (23)

Tag

6His, C-terminus (2)

6His, N-terminus (3)

DDK,C-terminus (1)

GST (1)

GST, N-terminus (1)

His (6)

His, N-Terminal (1)

His-GST (1)

His-T7 (2)

Myc-DDK (Flag) (3)

Species

Bovine (1)

Dog (1)

Horse (1)

Human (12)

Mouse (3)

Pig (1)

Rat (1)

Sheep (2)

Source

293T Cells (1)

Baculovirus (1)

E. coli (9)

HEK 293 Cells (5)

Human Cells (2)

Mammalian Cells (2)

Sf9 Cells (1)

Wheat Germ Extract (1)

Yeast (1)

Purification

Purified (1)

Low Endotoxin Level

Low endotoxin level (5)

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Human IL12B / IL12 p40 Protein (Recombinant DDK,C-terminus) - LS-G142320

Source:

Sf9 Cells

Tag:

DDK,C-terminus

Molecular Weight:

37 kDa

Price:

20 µg/$677

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Sheep IL12B / IL12 p40 Protein (Recombinant His) (aa23-327) - LS-G20859

Source:

E. coli

Tag:

His

Molecular Weight:

38.6 kD

Price:

1 mg/$1,679; 100 µg/$598; 20 µg/$405

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Bovine IL12B / IL12 p40 Protein (Recombinant His) (aa23-327) - LS-G23857

Source:

E. coli

Tag:

His

Molecular Weight:

38.3 kDa

Price:

10 µg/$289; 50 µg/$490; 100 µg/$782; 200 µg/$977; 1 mg/$2,114; 500 µg/$1,640; 5 mg/$3,417; 2 mg/$2,304

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Dog IL12B / IL12 p40 Protein (Recombinant His) (aa23-329) - LS-G23858

Source:

E. coli

Tag:

His

Molecular Weight:

38.6 kDa

Price:

10 µg/$286; 50 µg/$472; 100 µg/$752; 200 µg/$942; 1 mg/$2,069; 500 µg/$1,600; 5 mg/$3,291; 2 mg/$2,257

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Horse IL12B / IL12 p40 Protein (Recombinant His) (aa23-329) - LS-G23859

Source:

E. coli

Tag:

His

Molecular Weight:

38.6 kDa

Price:

10 µg/$287; 50 µg/$482; 100 µg/$770; 200 µg/$962; 1 mg/$2,094; 500 µg/$1,623; 5 mg/$3,361; 2 mg/$2,284

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Pig IL12B / IL12 p40 Protein (Recombinant His-GST) (aa23-324) - LS-G23860

Source:

E. coli

Tag:

His-GST

Molecular Weight:

64.3 kDa

Price:

10 µg/$291; 50 µg/$502; 100 µg/$802; 200 µg/$1,002; 1 mg/$2,144; 500 µg/$1,668; 5 mg/$3,501; 2 mg/$2,334

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Rat IL12B / IL12 p40 Protein (Recombinant His-T7) (aa30-311) - LS-G23861

Source:

E. coli

Tag:

His-T7

Molecular Weight:

35.8 kDa

Price:

10 µg/$287; 50 µg/$480; 100 µg/$767; 200 µg/$957; 1 mg/$2,089; 500 µg/$1,617; 5 mg/$3,347; 2 mg/$2,278

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Human IL12B / IL12 p40 Protein (Recombinant GST) (aa23-328) - LS-G22334

Source:

E. coli

Tag:

GST

Molecular Weight:

62.1 kD

Price:

1 mg/$1,355; 100 µg/$420; 20 µg/$323

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Sheep IL12B / IL12 p40 Protein (Recombinant His) (aa23-327) - LS-G22975

Source:

Yeast

Tag:

His

Molecular Weight:

26.6 kD

Price:

1 mg/$1,973; 100 µg/$679; 20 µg/$429

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Human IL12B / IL12 p40 Protein (Over-Expression Lysate 6His, N-terminus) (Ile23-Ser328) - LS-G26766

Source:

HEK 293 Cells

Tag:

6His, N-terminus

Molecular Weight:

37 kDa

Price:

100 µg/$298

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Human IL12B / IL12 p40 Protein (Over-Expression Cell Culture Supernatant 6His, N-terminus) (Ile23-Ser328) - LS-G26897

Source:

HEK 293 Cells

Tag:

6His, N-terminus

Molecular Weight:

37 kDa

Price:

200 µl/$283

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Human IL12B / IL12 p40 Protein (Recombinant GST, N-terminus) (aa229-328) - LS-G58983

Source:

Wheat Germ Extract

Tag:

GST, N-terminus

Price:

10 µg/$479; 25 µg/$670

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Human IL12B / IL12 p40 Protein (Recombinant Myc-DDK (Flag)) (Full Length) - LS-G66096

Source:

HEK 293 Cells

Tag:

Myc-DDK (Flag)

Molecular Weight:

34.6 kDa

Price:

20 µg/$1,107

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Human IL12B / IL12 p40 Protein (Over-Expression Lysate Myc-DDK (Flag)) (Full Length) - LS-G76901

Source:

293T Cells

Tag:

Myc-DDK (Flag)

Molecular Weight:

37.17 kDa

Price:

20 µg/$150

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IL12B / IL12 p40 Protein (Over-Expression Lysate Myc-DDK (Flag)) (Full Length) - LS-G99674

Source:

HEK 293 Cells

Tag:

Myc-DDK (Flag)

Molecular Weight:

37.17 kDa

Price:

100 µg/$494

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Human IL12B / IL12 p40 Protein (Recombinant His) - LS-G1708

Source:

Baculovirus

Tag:

His

Endotoxin Level:

Less than 1.0 EU/µg protein (determined by LAL method).

Price:

50 µg/$411; 250 µg/$985; 10 µg/$276

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Mouse IL12B / IL12 p40 Protein (Recombinant 6His, C-terminus) (Met23-Ser335) - LS-G139857

Source:

Mammalian Cells

Tag:

6His, C-terminus

Endotoxin Level:

Less than 1.0 EU/µg protein (determined by LAL method).

Molecular Weight:

37.1 kDa

Price:

10 µg/$288; 50 µg/$436

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Human IL12B / IL12 p40 Protein (Recombinant 6His, N-terminus) (Ile23-Ser328) - LS-G26471

Source:

E. coli

Tag:

6His, N-terminus

Molecular Weight:

37 kDa

Price:

10 µg/$265; 50 µg/$315; 100 µg/$365; 500 µg/$949

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Human IL12B / IL12 p40 Protein (Recombinant) (Ile23-Ser328) - LS-G139497

Source:

Mammalian Cells

Tag:

None

Endotoxin Level:

Less than 1.0 EU/µg protein (determined by LAL method).

Molecular Weight:

34.6 kDa

Price:

10 µg/$288; 50 µg/$436

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Human IL12B / IL12 p40 Protein (Recombinant) (Ile23-Ser328) - LS-G39987

Source:

Human Cells

Tag:

None

Endotoxin Level:

Less than 1.0 EU/µg protein (determined by LAL method).

Molecular Weight:

34.6kD

Price:

10 µg/$288; 50 µg/$442; 500 µg/$1,585; 1 mg/$2,157

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Human IL12B / IL12 p40 Protein (Recombinant His, N-Terminal) (Ile23-Ser328) - LS-G96856

Source:

HEK 293 Cells

Tag:

His, N-Terminal

Molecular Weight:

37 kDa (35-45 kDa reducing conditions)

Price:

10 µg/$289; 200 µg/$646; 50 µg/$360

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Mouse IL12B / IL12 p40 Protein (Recombinant 6His, C-terminus) (Met23-Ser335) - LS-G40183

Source:

Human Cells

Tag:

6His, C-terminus

Endotoxin Level:

Less than 1.0 EU/µg protein (determined by LAL method).

Molecular Weight:

37.1kD

Price:

10 µg/$288; 50 µg/$442; 500 µg/$1,585; 1 mg/$2,157

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Mouse IL12B / IL12 p40 Protein (Recombinant His-T7) (aa35-302) - LS-G11413

Source:

E. coli

Tag:

His-T7

Molecular Weight:

34.4 kDa

Price:

50 µg/$460; 10 µg/$284; 200 µg/$917; 100 µg/$735; 1 mg/$2,037; 500 µg/$1,571; 5 mg/$3,207; 2 mg/$2,225

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