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IKZF3 / AIOLOS

IKAROS family zinc finger 3 (Aiolos)

IKZF3 / AIOLOS is a member of the Ikaros family of zinc-finger proteins. Three members of this protein family (Ikaros, Aiolos and Helios) are hematopoietic-specific transcription factors involved in the regulation of lymphocyte development. This gene product is a transcription factor that is important in the regulation of B lymphocyte proliferation and differentiation. Both Ikaros and Aiolos can participate in chromatin remodeling. Regulation of gene expression in B lymphocytes by Aiolos is complex as it appears to require the sequential formation of Ikaros homodimers, Ikaros/Aiolos heterodimers, and Aiolos homodimers. Several alternative transcripts encoding different isoforms have been described, as well as some non-protein coding variants.

Gene Name: IKAROS family zinc finger 3 (Aiolos)
Synonyms: IKZF3, AIO, AIOLOS, Zinc finger protein Aiolos, ZNFN1A3
Target Sequences: NM_012481 NP_036613.2 Q9UKT9

Publications (1)

1
IRF4/MUM1 expression is associated with poor survival outcomes in patients with peripheral T-cell lymphoma. Heo MH, Park HY, Ko YH, Kim WS, Kim SJ. Journal of Cancer. 2017 8:1018-1024. (WB; Human) [Full Text Article] [PubMed:28529614] [PMC:PMC5436254] Related Antibodies: LS-C339163.

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Proteins (11)
Over-Expression Lysate (8)
Recombinant (3)
IKZF3 / AIOLOS (11)
No (11)
GST (1)
Myc-DDK (Flag) (10)
Human (7)
293T Cells (4)
HEK 293 Cells (6)
Wheat Germ Extract (1)
Purified (1)
IKZF3 / AIOLOS Protein - Western validation with an anti-DDK antibody * L: Control HEK293 lysate R: Over-expression lysate
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HEK 293 Cells
Myc-DDK (Flag)
51.5 kDa
100 µg/$710
IKZF3 / AIOLOS Protein - Western validation with an anti-DDK antibody * L: Control HEK293 lysate R: Over-expression lysate
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HEK 293 Cells
Myc-DDK (Flag)
48.9 kDa
100 µg/$710
IKZF3 / AIOLOS Protein - Western validation with an anti-DDK antibody * L: Control HEK293 lysate R: Over-expression lysate
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HEK 293 Cells
Myc-DDK (Flag)
57.8 kDa
100 µg/$494
IKZF3 / AIOLOS Protein - Western validation with an anti-DDK antibody * L: Control HEK293 lysate R: Over-expression lysate
Select
HEK 293 Cells
Myc-DDK (Flag)
48.9 kDa
100 µg/$494
IKZF3 / AIOLOS Protein - Purified recombinant protein IKZF3 was analyzed by SDS-PAGE gel and Coomassie Blue Staining
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HEK 293 Cells
Myc-DDK (Flag)
57.8 kDa
20 µg/$1,107
IKZF3 / AIOLOS Protein - Purified recombinant protein IKZF3 was analyzed by SDS-PAGE gel and Coomassie Blue Staining
Select
HEK 293 Cells
Myc-DDK (Flag)
46.8 kDa
20 µg/$1,107
IKZF3 / AIOLOS Protein - Western validation with an anti-DDK antibody * L: Control HEK293 lysate R: Over-expression lysate
Select
293T Cells
Myc-DDK (Flag)
57.8 kDa
20 µg/$150
IKZF3 / AIOLOS Protein - Western validation with an anti-DDK antibody * L: Control HEK293 lysate R: Over-expression lysate
Select
293T Cells
Myc-DDK (Flag)
51.5 kDa
20 µg/$215
Select
293T Cells
Myc-DDK (Flag)
48.9 kDa
20 µg/$150
IKZF3 / AIOLOS Protein - Western validation with an anti-DDK antibody * L: Control HEK293 lysate R: Over-expression lysate
Select
293T Cells
Myc-DDK (Flag)
48.9 kDa
20 µg/$215
IKZF3 / AIOLOS Protein - 12.5% SDS-PAGE of human ZNFN1A3 stained with Coomassie Blue
Select
Wheat Germ Extract
GST
81.73 kDa
2 µg/$439
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For RESEARCH USE ONLY. Intended for use by laboratory professionals. Not intended for human diagnostic or therapeutic purposes.

The data on this page has been compiled from LifeSpan internal sources, the National Center for Biotechnology Information (NCBI), and The Universal Protein Resource (UniProt).