IKZF1 / IKAROS

IKAROS family zinc finger 1 (Ikaros)

IKZF1 / IKAROS is a transcription factor that belongs to the family of zinc-finger DNA-binding proteins associated with chromatin remodeling. The expression of this protein is restricted to the fetal and adult hemo-lymphopoietic system, and it functions as a regulator of lymphocyte differentiation. Several alternatively spliced transcript variants encoding different isoforms have been described for this gene. Most isoforms share a common C-terminal domain, which contains two zinc finger motifs that are required for hetero- or homo-dimerization, and for interactions with other proteins. The isoforms, however, differ in the number of N-terminal zinc finger motifs that bind DNA and in nuclear localization signal presence, resulting in members with and without DNA-binding properties. Only a few isoforms contain the requisite three or more N-terminal zinc motifs that confer high affinity binding to a specific core DNA sequence element in the promoters of target genes. The non-DNA-binding isoforms are largely found in the cytoplasm, and are thought to function as dominant-negative factors. Overexpression of some dominant-negative isoforms have been associated with B-cell malignancies, such as acute lymphoblastic leukemia (ALL).

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ELISA Kits (4)

Type

Custom (2)

Sandwich (2)

Target

IKZF1 / IKAROS (4)

Reactivity

Human (2)

Mouse (1)

Chicken (1)

Format

96-Well Strip Plate (4)

Publications

No (4)

Sample Type

Cell Culture Supernatants (1)

Plasma (2)

Serum (2)

Tissue Homogenates (2)

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Human IKZF1 / IKAROS (Sandwich ELISA) ELISA Kit - LS-F13254

Type:

Sandwich

Format:

96-Well Strip Plate

Reactivity:

Human

Range:

0.156 - 10 ng/ml

Detection:

Colorimetric - 450nm (TMB)

Sample Types:

Cell Culture Supernatants, Plasma, Serum, Tissue Homogenates

Price:

1 Plate/$783

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Human IKZF1 / IKAROS (Sandwich ELISA) ELISA Kit - LS-F33087

Type:

Sandwich

Format:

96-Well Strip Plate

Reactivity:

Human

Range:

0.156 - 10 ng/ml

Detection:

Colorimetric - 450nm (TMB)

Sample Types:

Plasma, Serum, Tissue Homogenates

Price:

1 Plate/$579

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Chicken IKZF1 / IKAROS (Custom ELISA) ELISA Kit - LS-F17218

Type:

Custom

Format:

96-Well Strip Plate

Reactivity:

Chicken

Detection:

Colorimetric - 450nm (TMB)

Price:

1 Plate/$929

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Mouse IKZF1 / IKAROS (Custom ELISA) ELISA Kit - LS-F17219

Type:

Custom

Format:

96-Well Strip Plate

Reactivity:

Mouse

Detection:

Colorimetric - 450nm (TMB)

Price:

1 Plate/$783

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