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IGHMBP2
immunoglobulin mu binding protein 2
5' to 3' helicase that unwinds RNA and DNA duplices in an ATP-dependent reaction. Acts as a transcription regulator. Required for the transcriptional activation of the flounder liver-type antifreeze protein gene. Exhibits strong binding specificity to the enhancer element B of the flounder antifreeze protein gene intron. Binds to the insulin II gene RIPE3B enhancer region. May be involved in translation (By similarity). DNA-binding protein specific to 5'-phosphorylated single-stranded guanine-rich sequence related to the immunoglobulin mu chain switch region. Preferentially binds to the 5'-GGGCT-3' motif. Interacts with tRNA-Tyr. Stimulates the transcription of the human neurotropic virus JCV.
| Gene Name: | immunoglobulin mu binding protein 2 |
| Synonyms: | IGHMBP2, ATP-dependent helicase IGHMBP2, CATF1, HMN6, GF-1, HCSA, SMARD1, SMBP2, ZFAND7, Cardiac transcription factor 1, DNA-binding protein SMUBP-2, Glial factor 1, SMUBP2 |
| Target Sequences: | NM_002180 NP_002171.2 P38935 |
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