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IGF2

insulin-like growth factor 2 (somatomedin A)

The insulin-like growth factors possess growth-promoting activity. In vitro, they are potent mitogens for cultured cells. IGF-II is influenced by placental lactogen and may play a role in fetal development.Preptin undergoes glucose-mediated co-secretion with insulin, and acts as physiological amplifier of glucose-mediated insulin secretion. Exhibits osteogenic properties by increasing osteoblast mitogenic activity through phosphoactivation of MAPK1 and MAPK3.

Gene Name:	insulin-like growth factor 2 (somatomedin A)
Family/Subfamily:	Hormone , not assigned-Hormone
Synonyms:	IGF2, C11orf43, IGF-II, PP9974, Somatomedin-A
Target Sequences:	NM_000612 NP_000603.1 P01344

Publications (4)

Maternal supplementation of energy and protein, but not methionine hydroxy analog, enhanced postnatal growth and response to vaccination in Bos indicus-influenced beef offspring. Philipe Moriel, Marcelo Vedovatto, Elizabeth A Palmer, Rhaiza A Oliveira, Hiran Marcelo Silva, Juliana Ranches, Joao M B Vendramini. Journal of animal science. 2020 May;98: [Full Text Article] [PubMed:32309862] [PMC:PMC7228674]

Monensin supplementation during late gestation of beef cows alters maternal plasma concentrations of insulin-like growth factors 1 and 2 and enhances offspring preweaning growth. Marcelo Vedovatto, Vinicius Izquierdo, Elizabeth Palmer, Rhaiza A Oliveira, Hiran M Silva, João M B Vendramini, Philipe Moriel. Translational animal science. 2022 July;6:txac105. [Full Text Article] [PubMed:36046092] [PMC:PMC9423031]

Frequency of maternal supplementation of energy and protein during late gestation modulates preweaning growth of their beef offspring. Vinicius Izquierdo, Marcelo Vedovatto, Elizabeth A Palmer, Rhaiza A Oliveira, Hiran M Silva, João M B Vendramini, Philipe Moriel. Translational animal science. 2022 July;6:txac110. [Full Text Article] [PubMed:36090697] [PMC:PMC9449678]

The stem cell transcription factor ZFP57 induces IGF2 expression to promote anchorage-independent growth in cancer cells. Tada Y, Yamaguchi Y, Kinjo T, Song X, Akagi T, Takamura H, Ohta T, Yokota T, Koide H. Oncogene. 2014 Feb;34:752-60. [Full Text Article] [PubMed:24469060] Related Antibodies: LS-B7415.

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The data on this page has been compiled from LifeSpan internal sources, the National Center for Biotechnology Information (NCBI), and The Universal Protein Resource (UniProt).

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