IGF1R / IGF1 Receptor

insulin-like growth factor 1 receptor

Receptor tyrosine kinase which mediates actions of insulin-like growth factor 1 (IGF1). Binds IGF1 with high affinity and IGF2 and insulin (INS) with a lower affinity. The activated IGF1R is involved in cell growth and survival control. IGF1R is crucial for tumor transformation and survival of malignant cell. Ligand binding activates the receptor kinase, leading to receptor autophosphorylation, and tyrosines phosphorylation of multiple substrates, that function as signaling adapter proteins including, the insulin-receptor substrates (IRS1/2), Shc and 14-3-3 proteins. Phosphorylation of IRSs proteins lead to the activation of two main signaling pathways: the PI3K-AKT/PKB pathway and the Ras-MAPK pathway. The result of activating the MAPK pathway is increased cellular proliferation, whereas activating the PI3K pathway inhibits apoptosis and stimulates protein synthesis. Phosphorylated IRS1 can activate the 85 kDa regulatory subunit of PI3K (PIK3R1), leading to activation of several downstream substrates, including protein AKT/PKB. AKT phosphorylation, in turn, enhances protein synthesis through mTOR activation and triggers the antiapoptotic effects of IGFIR through phosphorylation and inactivation of BAD. In parallel to PI3K-driven signaling, recruitment of Grb2/SOS by phosphorylated IRS1 or Shc leads to recruitment of Ras and activation of the ras-MAPK pathway. In addition to these two main signaling pathways IGF1R signals also through the Janus kinase/signal transducer and activator of transcription pathway (JAK/STAT). Phosphorylation of JAK proteins can lead to phosphorylation/activation of signal transducers and activators of transcription (STAT) proteins. In particular activation of STAT3, may be essential for the transforming activity of IGF1R. The JAK/STAT pathway activates gene transcription and may be responsible for the transforming activity. JNK kinases can also be activated by the IGF1R. IGF1 exerts inhibiting activities on JNK activation via phosphorylation and inhibition of MAP3K5/ASK1, which is able to directly associate with the IGF1R.When present in a hybrid receptor with INSR, binds IGF1. PubMed:12138094 shows that hybrid receptors composed of IGF1R and INSR isoform Long are activated with a high affinity by IGF1, with low affinity by IGF2 and not significantly activated by insulin, and that hybrid receptors composed of IGF1R and INSR isoform Short are activated by IGF1, IGF2 and insulin. In contrast, PubMed:16831875 shows that hybrid receptors composed of IGF1R and INSR isoform Long and hybrid receptors composed of IGF1R and INSR isoform Short have similar binding characteristics, both bind IGF1 and have a low affinity for insulin.

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Proteins (15)

Type

Over-Expression Lysate (4)

Recombinant (11)

Target

IGF1R / IGF1 Receptor (15)

Publications

No (15)

Tag

6His, C-terminus (1)

6His, N-terminus (3)

DDK (Flag)-His, C-terminus (1)

DDK,C-terminus (1)

GST (1)

GST, N-terminus (1)

His (2)

His, N-Terminal (1)

His-T7 (1)

Myc-DDK (Flag) (3)

Species

Human (14)

Rat (1)

Source

293T Cells (1)

E. coli (4)

HEK 293 Cells (5)

Human (1)

Human Cells (1)

Sf9 Cells (1)

Wheat Germ Extract (1)

Yeast (1)

Purification

Purified (3)

Low Endotoxin Level

Low endotoxin level (2)

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Rat IGF1R / IGF1 Receptor Protein (Recombinant His, N-Terminal) (Tyr764-Leu956) - LS-G133070

Source:

E. coli

Tag:

His, N-Terminal

Molecular Weight:

25.7kDa

Price:

10 µg/$278; 50 µg/$422; 200 µg/$842; 100 µg/$672; 1 mg/$1,934; 500 µg/$1,480; 5 mg/$2,941; 2 mg/$2,119

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Human IGF1R / IGF1 Receptor Protein (Recombinant His) (aa763-931) - LS-G22403

Source:

E. coli

Tag:

His

Molecular Weight:

23.5 kD

Price:

1 mg/$1,355; 100 µg/$420; 20 µg/$323

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Human IGF1R / IGF1 Receptor Protein (Over-Expression Lysate 6His, N-terminus) (Arg960-Cys1367) - LS-G26743

Source:

HEK 293 Cells

Tag:

6His, N-terminus

Molecular Weight:

46 kDa

Price:

100 µg/$298

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Human IGF1R / IGF1 Receptor Protein (Over-Expression Lysate Myc-DDK (Flag)) (Full Length) - LS-G99196

Source:

HEK 293 Cells

Tag:

Myc-DDK (Flag)

Molecular Weight:

154.79 kDa

Price:

100 µg/$710

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Human IGF1R / IGF1 Receptor Protein (Recombinant 6His, N-terminus) - LS-G136594

Source:

Yeast

Tag:

6His, N-terminus

Molecular Weight:

21.4 kDa

Price:

100 µg/$446; 20 µg/$336; 1 mg/$1,460

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Human IGF1R / IGF1 Receptor Protein (Recombinant 6His, C-terminus) - LS-G146153

Source:

Human

Tag:

6His, C-terminus

Endotoxin Level:

Less than 1.0 EU/µg protein (determined by LAL method).

Molecular Weight:

103.7&81&22.7 kDa

Price:

10 µg/$290; 50 µg/$446

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Human IGF1R / IGF1 Receptor Protein (Recombinant DDK,C-terminus) - LS-G142365

Source:

Sf9 Cells

Tag:

DDK,C-terminus

Molecular Weight:

22.2 kDa

Price:

20 µg/$677

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Human IGF1R / IGF1 Receptor Protein (Recombinant DDK (Flag)-His, C-terminus) - LS-G142200

Source:

HEK 293 Cells

Tag:

DDK (Flag)-His, C-terminus

Molecular Weight:

25 kDa

Price:

20 µg/$1,107

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Human IGF1R / IGF1 Receptor Protein (Recombinant GST) (aa763-931) - LS-G20854

Source:

E. coli

Tag:

GST

Molecular Weight:

35.42 kD

Price:

100 µg/$420; 20 µg/$323

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Human IGF1R / IGF1 Receptor Protein (Over-Expression Lysate 6His, N-terminus) (Glu31-Asn932) - LS-G26723

Source:

HEK 293 Cells

Tag:

6His, N-terminus

Molecular Weight:

105 kDa

Price:

100 µg/$298

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Human IGF1R / IGF1 Receptor Protein (Over-Expression Lysate Myc-DDK (Flag)) (Full Length) - LS-G76790

Source:

293T Cells

Tag:

Myc-DDK (Flag)

Molecular Weight:

154.79 kDa

Price:

20 µg/$215

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Human IGF1R / IGF1 Receptor Protein (Recombinant His) (Met1-Asn932) - LS-G97065

Source:

Human Cells

Tag:

His

Endotoxin Level:

Less than 1.0 EU/µg protein (determined by LAL method).

Molecular Weight:

81, 23 and 104 kDa

Price:

100 µg/$843; 1 mg/$5,007

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Human IGF1R / IGF1 Receptor Protein (Recombinant GST, N-terminus) (aa761-870) - LS-G58959

Source:

Wheat Germ Extract

Tag:

GST, N-terminus

Price:

10 µg/$479; 25 µg/$670

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Human IGF1R / IGF1 Receptor Protein (Recombinant Myc-DDK (Flag)) (Full Length) - LS-G66036

Source:

HEK 293 Cells

Tag:

Myc-DDK (Flag)

Molecular Weight:

81 kDa

Price:

20 µg/$1,107

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Human IGF1R / IGF1 Receptor Protein (Recombinant His-T7) (aa763-955) - LS-G14142

Source:

E. coli

Tag:

His-T7

Molecular Weight:

25.8 kDa

Price:

50 µg/$362; 10 µg/$268; 200 µg/$722; 100 µg/$577; 1 mg/$1,755; 500 µg/$1,325; 5 mg/$2,708; 2 mg/$1,934

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