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IGF1
insulin-like growth factor 1 (somatomedin C)
The insulin-like growth factors, isolated from plasma, are structurally and functionally related to insulin but have a much higher growth-promoting activity. May be a physiological regulator of [1-14C]-2-deoxy-D-glucose (2DG) transport and glycogen synthesis in osteoblasts. Stimulates glucose transport in rat bone-derived osteoblastic (PyMS) cells and is effective at much lower concentrations than insulin, not only regarding glycogen and DNA synthesis but also with regard to enhancing glucose uptake. May play a role in synapse maturation.
| Gene Name: | insulin-like growth factor 1 (somatomedin C) |
| Family/Subfamily: | Hormone , not assigned-Hormone |
| Synonyms: | IGF1, IGF-IA, IGF-IB, IGFI, IBP1, IGF-I, Insulin-like growth factor 1, Insulin-like growth factor I, Insulin-like growth factor IA, Insulin-like growth factor IB, Mechano growth factor, Somatomedin-C, IGF1A, MGF |
| Target Sequences: | NM_000618 NP_000609.1 P05019 |
Publications (5)
1
Tumor-associated B-cells induce tumor heterogeneity and therapy resistance. Somasundaram R, Zhang G, Fukunaga-Kalabis M, Perego M, Krepler C, Xu X, Wagner C, Hristova D, Zhang J, Tian T, Wei Z, Liu Q, Garg K, Griss J, Hards R, Maurer M, Hafner C, Mayerhöfer M, Karanikas G, Jalili A, Bauer-Pohl V, Weihsengruber F, Rappersberger K, Koller J, Lang R, Hudgens C, Chen G, Tetzlaff M, Wu L, Frederick DT, Scolyer RA, Long GV, Damle M, Ellingsworth C, Grinman L, Choi H, Gavin BJ, Dunagin M, Raj A, Scholler N, Gross L, Beqiri M, Bennett K, Watson I, Schaider H, et al. Nature communications. 2017 8:607. (WB; Human)
[Full Text Article]
[PubMed:28928360]
Related Antibodies: LS-C7504.
2
Cytokine Mixtures Mimicking Secretomes From Mesenchymal Stem Cells Improve Medication-Related Osteonecrosis of the Jaw in a Rat Model. Ogata K, Matsumura M, Moriyama M, Katagiri W, Hibi H, Nakamura S. JBMR plus. 2017 September;2:69-80. [Full Text Article]
[PubMed:30283893]
[PMC:PMC6124208]
Related Antibodies: LS-C36891.
3
A defined mix of cytokines mimics conditioned medium from cultures of bone marrow-derived mesenchymal stem cells and elicits bone regeneration. Katagiri W, Sakaguchi K, Kawai T, Wakayama Y, Osugi M, Hibi H. Cell proliferation. 2017 June;50: [Full Text Article]
[PubMed:28133828]
Related Antibodies: LS-C36891.
☰ Filters
Products
Proteins
(64)
Type
Over-Expression Cell Culture Supernatant
(1)
Over-Expression Lysate
(8)
Recombinant
(54)
Target
IGF1
(64)
Format
Animal-free
(1)
Publications
No
(64)
Tag
6His, N-terminus
(6)
6His, N-terminus + Mouse IgG Fc, C-terminus
(1)
GST
(3)
GST, N-terminus
(2)
His
(3)
His, N-Terminal
(2)
His, N-terminus + Fc, C-terminus
(1)
His,C-terminus
(1)
His-GST
(5)
His-T7
(1)
Myc-DDK (Flag)
(7)
Species
Bovine
(3)
Chicken
(1)
Human
(38)
Mouse
(10)
Pig
(4)
Rabbit
(1)
Rat
(4)
Source
293F Cells
(1)
293T Cells
(3)
E. coli
(42)
HEK 293 Cells
(9)
Human
(1)
Wheat Germ Extract
(2)
Yeast
(3)
Purification
Purified
(17)
Supernatant
(1)
Low Endotoxin Level
Low endotoxin level
(25)
Biologically Active
Biologically active
(21)
Animal-free
Animal-free
(1)
E. coli
None
Biologically active
Less than 0.2 EU/µg protein (determined by LAL method).
7.7 kDa (SDS-PAGE)
50 µg/$286; 10 µg/$253; 1 mg/$330
E. coli
GST, N-terminus
28.4 kDa
10 µg/$283; 50 µg/$452; 100 µg/$722; 200 µg/$902; 1 mg/$2,016; 500 µg/$1,553; 5 mg/$3,151; 2 mg/$2,204
E. coli
None
Less than 0.1 ng/µg protein.
7.7 kDa
100 µg/$339; 1000 µg/$556; 500 µg/$429
E. coli
None
Biologically active
9.1 kDa
200 µg/$279; 1 mg/$365
E. coli
His-GST
40.0 kDa
10 µg/$226; 50 µg/$249; 100 µg/$271; 200 µg/$287; 1 mg/$572; 500 µg/$382; 5 mg/$1,189; 2 mg/$667
E. coli
His
9.2 kDa
10 µg/$238; 50 µg/$278; 100 µg/$319; 200 µg/$346; 1 mg/$1,012; 500 µg/$677; 5 mg/$1,785; 2 mg/$1,143
HEK 293 Cells
Myc-DDK (Flag)
17.76 kDa
100 µg/$494
HEK 293 Cells
Myc-DDK (Flag)
15.18 kDa
100 µg/$494
E. coli
6His, N-terminus
13.2 kDa
1 mg/$1,355; 100 µg/$420; 20 µg/$323
E. coli
None
Biologically active
9.1 kDa
200 µg/$268; 1 mg/$349
Wheat Germ Extract
GST
43.4 kDa
2 µg/$439
E. coli
His-GST
44.1 kDa
10 µg/$290; 50 µg/$500; 100 µg/$797; 200 µg/$997; 1 mg/$2,139; 500 µg/$1,662; 5 mg/$3,487; 2 mg/$2,329
E. coli
His-GST
42.6 kDa
10 µg/$290; 50 µg/$500; 100 µg/$797; 200 µg/$997; 1 mg/$2,139; 500 µg/$1,662; 5 mg/$3,487; 2 mg/$2,329
E. coli
GST
35 kD
1 mg/$1,355; 100 µg/$420; 20 µg/$323
E. coli
GST
35.1 kD
1 mg/$1,679; 100 µg/$500; 20 µg/$364
HEK 293 Cells
6His, N-terminus
17 kDa
100 µg/$298
E. coli
None
Biologically active
Less than 0.2 EU/µg protein (determined by LAL method).
7.8 kDa (SDS-PAGE)
50 µg/$286; 10 µg/$246; 1 mg/$990
HEK 293 Cells
6His, N-terminus + Mouse IgG Fc, C-terminus
43-45 kDa
10 µg/$289; 50 µg/$360; 100 µg/$432
293T Cells
Myc-DDK (Flag)
17.76 kDa
20 µg/$150
293T Cells
Myc-DDK (Flag)
17.03 kDa
20 µg/$150
293T Cells
Myc-DDK (Flag)
15.18 kDa
20 µg/$150
Viewing 1-25
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product results
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