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Required for the formation of cilia. Plays an indirect role in sonic hedgehog signaling, cilia being required for all activity of the hedgehog pathway By similarity. Has pro-apoptotic function via its interaction with HIP1, leading to recruit caspase-8 (CASP8) and trigger apoptosis. Has the ability to bind DNA sequence motif 5'-AAAGACATG-3' present in the promoter of caspase genes such as CASP1, CASP8 and CASP10, suggesting that it may act as a transcription regulator; however the relevance of such function remains unclear.
Gene Name: | intraflagellar transport 57 homolog (Chlamydomonas) |
Synonyms: | IFT57, MHS4R2, HIP1-interacting protein, DERP8, ESRRBL1, HIP1 protein interactor, HIPPI |
Target Sequences: | AF245220 AAK28373.1 Q9NWB7 |
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