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IFRD1 / TIS7 is an immediate early gene that encodes a protein related to interferon-gamma. This protein may function as a transcriptional co-activator/repressor that controls the growth and differentiation of specific cell types during embryonic development and tissue regeneration. Mutations in this gene are associated with sensory/motor neuropathy with ataxia. This gene may also be involved in modulating the pathogenesis of cystic fibrosis lung disease. Alternate splicing results in multiple transcript variants.
Gene Name: | interferon-related developmental regulator 1 |
Synonyms: | IFRD1, PC4, TIS7, Pheochromocytoma cell-4, TPA induced sequence 7 |
Target Sequences: | NM_001550 NP_001541.2 O00458 |
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