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IFN Gamma / Interferon Gamma

interferon, gamma

Produced by lymphocytes activated by specific antigens or mitogens. IFN-gamma, in addition to having antiviral activity, has important immunoregulatory functions. It is a potent activator of macrophages, it has antiproliferative effects on transformed cells and it can potentiate the antiviral and antitumor effects of the type I interferons.

Gene Name:	interferon, gamma
Family/Subfamily:	Interferon , not assigned-Interferon
Synonyms:	IFNG, IFG, Immune interferon, IFI, Interferon gamma, IFN-gamma, Interferon, gamma, IFNY
Target Sequences:	NM_000619 NP_000610.2 P01579

Publications (4)

TNF-alpha drives human CD14+ monocytes to differentiate into CD70+ dendritic cells evoking Th1 and Th17 responses. Iwamoto S, Iwai S, Tsujiyama K, Kurahashi C, Takeshita K, Naoe M, Masunaga A, Ogawa Y, Oguchi K, Miyazaki A. Journal of immunology (Baltimore, Md. : 1950). 2007 179:1449-57. [PubMed:17641010] Related Antibodies: LS-C41022.

Retinoid-X-receptors (a/ß) in melanocytes modulate innate immune responses and differentially regulate cell survival following UV irradiation. Coleman DJ, Garcia G, Hyter S, Jang HS, Chagani S, Liang X, Larue L, Ganguli-Indra G, Indra AK. PLoS genetics. 2014 10:e1004321. (Neut; Mouse) [Full Text Article] [PubMed:24810760] [PMC:PMC4014444] Related Antibodies: LS-C85867.

Sequential Immunization With Live-Attenuated Chimeric Hemagglutinin-Based Vaccines Confers Heterosubtypic Immunity Against Influenza A Viruses in a Preclinical Ferret Model. Liu WC, Nachbagauer R, Stadlbauer D, Solórzano A, Berlanda-Scorza F, García-Sastre A, Palese P, Krammer F, Albrecht RA. Frontiers in immunology. 2019 April;10: [Full Text Article] [PubMed:31105689] [PMC:PMC6499175] Related Antibodies: LS-C188182.

High Levels of IL-18 and IFN-? in Chronically Inflamed Tissue in Chronic Granulomatous Disease. Meda Spaccamela V, Valencia RG, Pastukhov O, Duppenthaler A, Dettmer MS, Erb J, Steiner UC, Hillinger S, Speckmann C, Ehl S, Reichenbach J, Siler U. Frontiers in immunology. 2019 October;10: [Full Text Article] [PubMed:31681257] [PMC:PMC6813411] Related Antibodies: LS-B7487.

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