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IFITM5

interferon induced transmembrane protein 5

IFITM5 is a membrane protein thought to play a role in bone mineralization. This gene is located on chromosome 11 in a cluster of related genes which are induced by interferon, however, this gene has not been shown to be interferon inducible. A similar gene, located in a gene cluster on mouse chromosome 7, is a member of the interferon-inducible fragilis gene family. The mouse gene encodes a transmembrane protein described as participating in germ cell competence. A mutation in the 5' UTR of this gene has been associated with osteogenesis imperfecta type V (PMID: 22863190, 22863195).

Gene Name: interferon induced transmembrane protein 5
Synonyms: IFITM5, BRIL, Dispanin subfamily A member 1, DSPA1, Fragilis4, OI5, Hrmp1
Target Sequences: NP_001020466.1 A6NNB3

Publications (1)

1
A single recurrent mutation in the 5'-UTR of IFITM5 causes osteogenesis imperfecta type V. Cho TJ, Lee KE, Lee SK, Song SJ, Kim KJ, Jeon D, Lee G, Kim HN, Lee HR, Eom HH, Lee ZH, Kim OH, Park WY, Park SS, Ikegawa S, Yoo WJ, Choi IH, Kim JW. American journal of human genetics. 2012 91:343-8. [PubMed:22863190] [PMC:PMC3415533]

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For RESEARCH USE ONLY. Intended for use by laboratory professionals. Not intended for human diagnostic or therapeutic purposes.

The data on this page has been compiled from LifeSpan internal sources, the National Center for Biotechnology Information (NCBI), and The Universal Protein Resource (UniProt).