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IFITM5 is a membrane protein thought to play a role in bone mineralization. This gene is located on chromosome 11 in a cluster of related genes which are induced by interferon, however, this gene has not been shown to be interferon inducible. A similar gene, located in a gene cluster on mouse chromosome 7, is a member of the interferon-inducible fragilis gene family. The mouse gene encodes a transmembrane protein described as participating in germ cell competence. A mutation in the 5' UTR of this gene has been associated with osteogenesis imperfecta type V (PMID: 22863190, 22863195).
Gene Name: | interferon induced transmembrane protein 5 |
Synonyms: | IFITM5, BRIL, Dispanin subfamily A member 1, DSPA1, Fragilis4, OI5, Hrmp1 |
Target Sequences: | NP_001020466.1 A6NNB3 |
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