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May play a role in the ERK signaling pathway by inhibiting the dephosphorylation of ERK by phosphatase PP2A-PPP2R5C holoenzyme. Acts also as an ERK downstream effector mediating survival. As a member of the NUPR1/RELB/IER3 survival pathway, may provide pancreatic ductal adenocarcinoma with remarkable resistance to cell stress, such as starvation or gemcitabine treatment.
Gene Name: | immediate early response 3 |
Synonyms: | IER3, DIF-2, DIF2, Gly96, mouse, homolog of, IEX1, IEX-1L, Immediate early protein GLY96, Immediate early response 3, Immediately early gene X-1, GLY96, IEX-1, Protein DIF-2, Protein PRG1, PRG1, Anti-death protein |
Target Sequences: | NM_003897 NP_003888.2 P46695 |
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