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IDO1 / IDO

indoleamine 2,3-dioxygenase 1

IDO1 / IDO is indoleamine 2,3-dioxygenase (IDO) - a heme enzyme that catalyzes the first and rate-limiting step in tryptophan catabolism to N-formyl-kynurenine. This enzyme acts on multiple tryptophan substrates including D-tryptophan, L-tryptophan, 5-hydroxy-tryptophan, tryptamine, and serotonin. This enzyme is thought to play a role in a variety of pathophysiological processes such as antimicrobial and antitumor defense, neuropathology, immunoregulation, and antioxidant activity. Through its expression in dendritic cells, monocytes, and macrophages this enzyme modulates T-cell behavior by its peri-cellular catabolization of the essential amino acid tryptophan.

Gene Name:	indoleamine 2,3-dioxygenase 1
Synonyms:	IDO1, IDO, Indole 2,3-dioxygenase, Indolamine 2,3 dioxygenase, IDO-1, INDO, Indoleamine 2,3-dioxygenase, Indoleamine 2,3-dioxygenase 1
Target Sequences:	NM_002164 AAA36081.1 P14902

Publications (13)

Synovial autoreactive T cells in rheumatoid arthritis resist IDO-mediated inhibition. Zhu L, Ji F, Wang Y, Zhang Y, Liu Q, Zhang JZ, Matsushima K, Cao Q, Zhang Y. Journal of immunology (Baltimore, Md. : 1950). 2006 177:8226-33. [PubMed:17114500] Related Antibodies: LS-C153780.

Imaging correlates of differential expression of indoleamine 2,3-dioxygenase in human brain tumors. Batista CE, Juhsz C, Muzik O, Kupsky WJ, Barger G, Chugani HT, Mittal S, Sood S, Chakraborty PK, Chugani DC. Molecular imaging and biology : MIB : the official publication of the Academy of Molecular Imaging. 11:460-6. [PubMed:19434461] [PMC:PMC2763988] Related Antibodies: LS-C153780.

Loss of survival factors and activation of inflammatory cascades in brain sympathetic centers in type 1 diabetic mice. Hu P, Thinschmidt JS, Caballero S, Adamson S, Cole L, Chan-Ling T, Grant MB. American journal of physiology. Endocrinology and metabolism. 2015 308:E688-98. (IHC, IF; Mouse) [Full Text Article] [PubMed:25714673] [PMC:PMC4398829] Related Antibodies: LS-B1746.

Psoriasis is characterized by deficient negative immune regulation compared to transient delayed-type hypersensitivity reactions. Gulati N, Suárez-FariÃ±as M, Correa da Rosa J, Krueger JG. F1000Research. 2015 4:149. (IHC; Human) [Full Text Article] [PubMed:26236467] [PMC:PMC4505786] Related Antibodies: LS-C153780.

Increased Indoleamine 2,3-Dioxygenase and Quinolinic Acid Expression in Microglia and Müller Cells of Diabetic Human and Rodent Retina. Hu P, Hunt NH, Arfuso F, Shaw LC, Uddin MN, Zhu M, Devasahayam R, Adamson SJ, Benson VL, Chan-Ling T, Grant MB,. Investigative ophthalmology & visual science. 2017 58:5043-5055. (ELISA; Human) [Full Text Article] [PubMed:28980000] Related Antibodies: LS-B1746.

Clinical significance of tryptophan catabolism in Hodgkin lymphoma. Masaki A, Ishida T, Maeda Y, Ito A, Suzuki S, Narita T, Kinoshita S, Takino H, Yoshida T, Ri M, Kusumoto S, Komatsu H, Inagaki H, Ueda R, Choi I, Suehiro Y, Iida S. Cancer science. 2018 January;109:74-83. (Human) [Full Text Article] [PubMed:29080383] [PMC:PMC5765298] Related Antibodies: LS-C338105.

Indoleamine 2,3-dioxygenase regulates anti-tumor immunity in lung cancer by metabolic reprogramming of immune cells in the tumor microenvironment. Schafer CC, Wang Y, Hough KP, Sawant A, Grant SC, Thannickal VJ, Zmijewski J, Ponnazhagan S, Deshane JS. Oncotarget. 2016 November;7:75407-75424. [Full Text Article] [PubMed:27705910] [PMC:PMC5340181] Related Antibodies: LS-C153780.

IL-32 induces indoleamine 2,3-dioxygenase+CD1c+ dendritic cells and indoleamine 2,3-dioxygenase+CD163+ macrophages: Relevance to mycosis fungoides progression. Ohmatsu H, Humme D, Gonzalez J, Gulati N, Möbs M, Sterry W, Krueger JG. Oncoimmunology. 2016 May;6:e1181237. [Full Text Article] [PubMed:28344860] [PMC:PMC5353917] Related Antibodies: LS-C153780.

Biomarkers of inflammation, immunosuppression and stress with active disease are revealed by metabolomic profiling of tuberculosis patients. January Weiner rd, Shreemanta K Parida, Jeroen Maertzdorf, Gillian F Black, Dirk Repsilber, Anna Telaar, Robert P Mohney, Cordelia Arndt-Sullivan, Christian A Ganoza, Kellen C Faé, Gerhard Walzl, Stefan H E Kaufmann. PloS one. 2012 July;7:e40221. [Full Text Article] [PubMed:22844400] [PMC:PMC3402490] Related Antibodies: LS-B1746.

Selected Uterine Immune Events Associated With the Establishment of Pregnancy in the Dog. Miguel Tavares Pereira, Renata Nowaczyk, Rita Payan-Carreira, Sonia Miranda, Selim Aslan, Duygu Kaya, Mariusz P Kowalewski. Frontiers in veterinary science. 2021 Feb;7:625921. [Full Text Article] [PubMed:33634180] [PMC:PMC7900146] Related Antibodies: LS-C174759.

Diabetic Kidney Disease Alters the Transcriptome and Function of Human Adipose-Derived Mesenchymal Stromal Cells but Maintains Immunomodulatory and Paracrine Activities Important for Renal Repair. LaTonya J Hickson, Alfonso Eirin, Sabena M Conley, Timucin Taner, Xiaohui Bian, Ahmed Saad, Sandra M Herrmann, Ramila A Mehta, Travis J McKenzie, Todd A Kellogg, James L Kirkland, Tamar Tchkonia, Ishran M Saadiq, Hui Tang, Kyra L Jordan, Xiangyang Zhu, Mathew D Griffin, Andrew D Rule, Andre J van Wijnen, Stephen C Textor, Lilach O Lerman. Diabetes. 2021 July;70:1561-1574. [Full Text Article] [PubMed:33858824] [PMC:PMC8336004]

Regulation of indoleamine 2, 3-dioxygenase in hippocampal microglia by NLRP3 inflammasome in lipopolysaccharide-induced depressive-like behaviors. Shanshan Zhang, Ying Zong, Zhonggan Ren, Juntao Hu, Xinyuan Wu, Honglei Xiao, Song Qin, Guomin Zhou, Yuanyuan Ma, Yaodong Zhang, Jin Yu, Kaidi Wang, Guocai Lu, Qiong Liu. The European journal of neuroscience. 2020 December;52:4586-4601. [Full Text Article] [PubMed:33098156] Related Antibodies: LS-C153837.

Indoleamine 2,3-dioxygenase affects the aggressiveness of intraductal papillary mucinous neoplasms through Foxp3+CD4+CD25+ T cells in peripheral blood. Ikemoto T, Shimada M, Komatsu M, Yamada S, Saito Y, Mori H, Morine Y, Imura S, Bando Y, Utsunomiya T. Pancreas. 2013 Jan;42:130-4. [Full Text Article] [PubMed:22722263] Related Antibodies: LS-C123833.

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For RESEARCH USE ONLY. Intended for use by laboratory professionals. Not intended for human diagnostic or therapeutic purposes.

The data on this page has been compiled from LifeSpan internal sources, the National Center for Biotechnology Information (NCBI), and The Universal Protein Resource (UniProt).

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