IDE

insulin-degrading enzyme

IDE is a zinc metallopeptidase that degrades intracellular insulin, and thereby terminates insulins activity, as well as participating in intercellular peptide signalling by degrading diverse peptides such as glucagon, amylin, bradykinin, and kallidin. The preferential affinity of this enzyme for insulin results in insulin-mediated inhibition of the degradation of other peptides such as beta-amyloid. Deficiencies in this protein's function are associated with Alzheimer's disease and type 2 diabetes mellitus but mutations in this gene have not been shown to be causitive for these diseases. This protein localizes primarily to the cytoplasm but in some cell types localizes to the extracellular space, cell membrane, peroxisome, and mitochondrion. Alternative splicing results in multiple transcript variants encoding distinct isoforms. Additional transcript variants have been described but have not been experimentally verified.

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Products

ELISA Kits (21)

Type

Competitive EIA (3)

Custom (2)

Development Kit (1)

Sandwich (14)

Sandwich CLIA (1)

Target

IDE (21)

Reactivity

Human (7)

Mouse (4)

Rat (4)

Chicken (1)

Guinea pig (1)

Monkey (1)

Porcine (1)

Rabbit (1)

Product Group

DevKit DuoPlus (1)

Format

12 x 8-Well Microstrips (1)

96-Well Microplate (2)

96-Well Strip Plate (17)

Antibody Pair and Standard (1)

Publications

No (21)

Sample Type

Cell Lysates (1)

Plasma (13)

Serum (13)

Tissue Homogenates (6)

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Mouse IDE (Sandwich ELISA) ELISA Kit - LS-F5702

Type:

Sandwich

Format:

96-Well Strip Plate

Reactivity:

Mouse

Range:

0.156 - 10 ng/ml

Detection:

Colorimetric - 450nm (TMB)

Sample Types:

Plasma, Serum, Tissue Homogenates

Price:

1 Plate/$818

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Human IDE (Sandwich ELISA) ELISA Kit - LS-F6210

Type:

Sandwich

Format:

96-Well Strip Plate

Reactivity:

Human

Range:

1.56 - 100 ng/ml

Detection:

Colorimetric - 450nm (TMB)

Sample Types:

Plasma, Serum, Tissue Homogenates

Price:

1 Plate/$798

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Human IDE (Sandwich ELISA) ELISA Kit - LS-F23775

Type:

Sandwich

Format:

96-Well Microplate

Reactivity:

Human

Range:

62.5 - 4000 pg/ml

Detection:

Colorimetric - 450nm (TMB)

Sample Types:

Plasma, Serum

Price:

1 Plate/$651

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Mouse IDE (Sandwich ELISA) ELISA Kit - LS-F34737

Type:

Sandwich

Format:

96-Well Strip Plate

Reactivity:

Mouse

Range:

0.313 - 20 ng/ml

Detection:

Colorimetric - 450nm (TMB)

Sample Types:

Plasma, Serum, Tissue Homogenates

Price:

1 Plate/$579

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Human IDE (Sandwich ELISA) ELISA Kit - LS-F34736

Type:

Sandwich

Format:

96-Well Strip Plate

Reactivity:

Human

Range:

62.5 - 4000 pg/ml

Detection:

Colorimetric - 450nm (TMB)

Sample Types:

Plasma, Serum, Tissue Homogenates

Price:

1 Plate/$579

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Rat IDE (Sandwich ELISA) ELISA Kit - LS-F7574

Type:

Sandwich

Format:

96-Well Strip Plate

Reactivity:

Rat

Range:

0.313 - 20 ng/ml

Detection:

Colorimetric - 450nm (TMB)

Sample Types:

Cell Lysates, Tissue Homogenates

Price:

1 Plate/$856

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Mouse IDE (Sandwich ELISA) ELISA Kit - LS-F11706

Type:

Sandwich

Format:

96-Well Strip Plate

Reactivity:

Mouse

Range:

0.312 - 20 ng/ml

Detection:

Colorimetric - 450nm (TMB)

Sample Types:

Plasma, Serum

Price:

1 Plate/$783

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Chicken IDE (Sandwich ELISA) ELISA Kit - LS-F44951

Type:

Sandwich

Format:

96-Well Strip Plate

Reactivity:

Chicken

Range:

3.125 - 200 ng/ml

Detection:

Colorimetric - 450nm (TMB)

Price:

1 Plate/$728

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Guinea pig IDE (Sandwich ELISA) ELISA Kit - LS-F44952

Type:

Sandwich

Format:

96-Well Strip Plate

Reactivity:

Guinea pig

Range:

0.625 - 40 ng/ml

Detection:

Colorimetric - 450nm (TMB)

Price:

1 Plate/$728

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Monkey IDE (Sandwich ELISA) ELISA Kit - LS-F44953

Type:

Sandwich

Format:

96-Well Strip Plate

Reactivity:

Monkey

Range:

62.5 - 4000 pg/ml

Detection:

Colorimetric - 450nm (TMB)

Price:

1 Plate/$728

Select

Porcine IDE (Sandwich ELISA) ELISA Kit - LS-F44954

Type:

Sandwich

Format:

96-Well Strip Plate

Reactivity:

Porcine

Range:

62.5 - 4000 pg/ml

Detection:

Colorimetric - 450nm (TMB)

Price:

1 Plate/$728

Select

Rabbit IDE (Sandwich ELISA) ELISA Kit - LS-F44956

Type:

Sandwich

Format:

96-Well Strip Plate

Reactivity:

Rabbit

Range:

3.125 - 200 ng/ml

Detection:

Colorimetric - 450nm (TMB)

Price:

1 Plate/$728

Select

DevKit DuoPlus Human IDE ELISA Development Kit - LS-F71440

Type:

Development Kit

Format:

Antibody Pair and Standard

Reactivity:

Human

Range:

0.625 - 40 ng/ml

Detection:

Colorimetric - 450nm (TMB)

Sample Types:

Plasma, Serum, Tissue Homogenates

Price:

500 Wells/$1,080; 1000 Wells/$1,577

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Bovine IDE (Custom ELISA) ELISA Kit - LS-F18755

Type:

Custom

Format:

96-Well Strip Plate

Detection:

Colorimetric - 450nm (TMB)

Price:

1 Plate/$783

Select

Rat IDE (Custom ELISA) ELISA Kit - LS-F18756

Type:

Custom

Format:

96-Well Strip Plate

Reactivity:

Rat

Detection:

Colorimetric - 450nm (TMB)

Price:

1 Plate/$783

Select

Human IDE (CLIA) ELISA Kit - LS-F29382

Type:

Sandwich CLIA

Format:

12 x 8-Well Microstrips

Reactivity:

Human

Range:

15.625 - 1000 pg/ml

Detection:

Chemiluminescent

Sample Types:

Plasma, Serum

Price:

1 Plate/$728

Select

Rat IDE (Sandwich ELISA) ELISA Kit - LS-F22381

Type:

Sandwich

Format:

96-Well Microplate

Reactivity:

Rat

Range:

0.313 - 20 ng/ml

Detection:

Colorimetric - 450nm (TMB)

Sample Types:

Plasma, Serum

Price:

1 Plate/$651

Select

Human IDE (Competitive EIA) ELISA Kit - LS-F27724

Type:

Competitive EIA

Format:

96-Well Strip Plate

Reactivity:

Human

Range:

250 - 5000 pg/ml

Detection:

Colorimetric - 450nm (TMB)

Sample Types:

Plasma, Serum

Price:

1 Plate/$913

Select

Rat IDE (Competitive EIA) ELISA Kit - LS-F28002

Type:

Competitive EIA

Format:

96-Well Strip Plate

Reactivity:

Rat

Range:

1 - 25 ng/ml

Detection:

Colorimetric - 450nm (TMB)

Sample Types:

Plasma, Serum

Price:

1 Plate/$913

Select

Mouse IDE (Competitive EIA) ELISA Kit - LS-F28446

Type:

Competitive EIA

Format:

96-Well Strip Plate

Reactivity:

Mouse

Range:

1 - 25 ng/ml

Detection:

Colorimetric - 450nm (TMB)

Sample Types:

Plasma, Serum

Price:

1 Plate/$913

Select

Human IDE (Sandwich ELISA) ELISA Kit - LS-F11707

Type:

Sandwich

Format:

96-Well Strip Plate

Reactivity:

Human

Range:

0.156 - 10 ng/ml

Detection:

Colorimetric - 450nm (TMB)

Sample Types:

Plasma, Serum

Price:

1 Plate/$783

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