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ID2

inhibitor of DNA binding 2, dominant negative helix-loop-helix protein

Transcriptional regulator (lacking a basic DNA binding domain) which negatively regulates the basic helix-loop-helix (bHLH) transcription factors by forming heterodimers and inhibiting their DNA binding and transcriptional activity. Implicated in regulating a variety of cellular processes, including cellular growth, senescence, differentiation, apoptosis, angiogenesis, and neoplastic transformation. Inhibits skeletal muscle and cardiac myocyte differentiation. Regulates the circadian clock by repressing the transcriptional activator activity of the CLOCK-ARNTL/BMAL1 heterodimer. Restricts the CLOCK and ARNTL/BMAL1 localization to the cytoplasm. Plays a role in both the input and output pathways of the circadian clock: in the input component, is involved in modulating the magnitude of photic entrainment and in the output component, contributes to the regulation of a variety of liver clock-controlled genes involved in lipid metabolism.

Gene Name: inhibitor of DNA binding 2, dominant negative helix-loop-helix protein
Synonyms: ID2, BHLHb26, Cell growth-inhibiting gene 8, ID2H, Inhibitor of differentiation 2, GIG8, Helix-loop-helix protein ID2, ID2A, Inhibitor of DNA binding 2
Target Sequences: NM_002166 NP_002157.2 Q02363

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Products
Proteins (7)
Over-Expression Lysate (2)
Recombinant (5)
ID2 (7)
No (7)
GST (1)
GST, N-terminus (1)
His (1)
His-SUMO (1)
Myc-DDK (Flag) (3)
Human (6)
293T Cells (1)
E. coli (2)
HEK 293 Cells (2)
Wheat Germ Extract (2)
Purified (2)
ID2 Protein
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E. coli
His
100 µg/$361; 500 µg/$739; 20 µg/$261
ID2 Protein
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E. coli
His-SUMO
30.9 kD
1 mg/$1,355; 100 µg/$420; 20 µg/$323
ID2 Protein - 12.5% SDS-PAGE of human ID2 stained with Coomassie Blue
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Wheat Germ Extract
GST
40.48 kDa
10 µg/$479; 25 µg/$670
ID2 Protein - Western validation with an anti-DDK antibody * L: Control HEK293 lysate R: Over-expression lysate
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293T Cells
Myc-DDK (Flag)
14.7 kDa
20 µg/$150
ID2 Protein - Purified recombinant protein ID2 was analyzed by SDS-PAGE gel and Coomassie Blue Staining
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HEK 293 Cells
Myc-DDK (Flag)
14.7 kDa
20 µg/$1,107
ID2 Protein - 12.5% SDS-PAGE Stained with Coomassie Blue.
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Wheat Germ Extract
GST, N-terminus
10 µg/$479; 25 µg/$670
ID2 Protein - Western validation with an anti-DDK antibody * L: Control HEK293 lysate R: Over-expression lysate
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HEK 293 Cells
Myc-DDK (Flag)
14.7 kDa
100 µg/$494
Viewing 1-7 of 7 product results


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PLEASE NOTE

For RESEARCH USE ONLY. Intended for use by laboratory professionals. Not intended for human diagnostic or therapeutic purposes.

The data on this page has been compiled from LifeSpan internal sources, the National Center for Biotechnology Information (NCBI), and The Universal Protein Resource (UniProt).