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Enhances all basic T-cell responses to a foreign antigen, namely proliferation, secretion of lymphokines, up-regulation of molecules that mediate cell-cell interaction, and effective help for antibody secretion by B-cells. Essential both for efficient interaction between T and B-cells and for normal antibody responses to T-cell dependent antigens. Does not up-regulate the production of interleukin-2, but superinduces the synthesis of interleukin-10. Prevents the apoptosis of pre-activated T-cells. Plays a critical role in CD40-mediated class switching of immunoglobin isotypes.
Gene Name: | inducible T-cell co-stimulator |
Synonyms: | ICOS, AILIM, CD278, CVID1, Inducible costimulator, Inducible T-cell co-stimulator, CD278 antigen, Inducible T-cell costimulator |
Target Sequences: | AJ277832 CAC06612.1 Q9Y6W8 |
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