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IBSP / Bone Sialoprotein

integrin-binding sialoprotein

IBSP / Bone Sialoprotein is a major structural protein of the bone matrix. It constitutes approximately 12% of the noncollagenous proteins in human bone and is synthesized by skeletal-associated cell types, including hypertrophic chondrocytes, osteoblasts, osteocytes, and osteoclasts. The only extraskeletal site of its synthesis is the trophoblast. This protein binds to calcium and hydroxyapatite via its acidic amino acid clusters, and mediates cell attachment through an RGD sequence that recognizes the vitronectin receptor.

Gene Name: integrin-binding sialoprotein
Synonyms: IBSP, Bone Sialoprotein, Bone sialoprotein II, BSP, BSP II, Cell-binding sialoprotein, BNSP, Bone Sialprotein II, Integrin-binding sialoprotein, Bone sialoprotein 2, BSP-II, SP-II
Target Sequences: NM_004967 NP_004958.2 P21815

Publications (2)

1
BMP-induced Atoh8 attenuates osteoclastogenesis by suppressing Runx2 transcriptional activity and reducing the Rankl/Opg expression ratio in osteoblasts. Yuhei Yahiro #, Shingo Maeda #, Masato Morikawa, Daizo Koinuma, Go Jokoji, Toshiro Ijuin, Setsuro Komiya, Ryoichiro Kageyama, Kohei Miyazono, Noboru Taniguchi. Bone research. 2020 September;8:32. [Full Text Article] [PubMed:32923015] [PMC:PMC7463266] Related Antibodies: LS-C190916.
2
Human immunodeficiency virus type 1 enhancer-binding protein 3 is essential for the expression of asparagine-linked glycosylation 2 in the regulation of osteoblast and chondrocyte differentiation. Imamura K, Maeda S, Kawamura I, Matsuyama K, Shinohara N, Yahiro Y, Nagano S, Setoguchi T, Yokouchi M, Ishidou Y, Komiya S. The Journal of biological chemistry. 2014 Apr;289:9865-79. [Full Text Article] [PubMed:24563464] [PMC:PMC3975031] Related Antibodies: LS-C190916.

☰ Filters
Products
Proteins (9)
Over-Expression Lysate (2)
Recombinant (7)
IBSP / Bone Sialoprotein (9)
No (9)
6His-SUMO, N-terminus (1)
DDK (Flag)-10His, C-terminus (1)
DDK (Flag)-6His, C-terminus (1)
His (1)
His, C-Terminal (1)
His, N-Terminal (1)
His,C-terminus (1)
Myc-DDK (Flag) (2)
Human (6)
Mouse (2)
293T Cells (1)
E. coli (3)
HEK 293 Cells (3)
Human (1)
Mammalian Cells (1)
Purified (1)
Low endotoxin level (3)
IBSP / Bone Sialoprotein Protein - Western validation with an anti-DDK antibody * L: Control HEK293 lysate R: Over-expression lysate
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HEK 293 Cells
Myc-DDK (Flag)
35.02 kDa
100 µg/$494
IBSP / Bone Sialoprotein Protein
Select
HEK 293 Cells
DDK (Flag)-10His, C-terminus
36 kDa
20 µg/$1,107
IBSP / Bone Sialoprotein Protein
Select
HEK 293 Cells
DDK (Flag)-6His, C-terminus
35.5 kDa
20 µg/$1,107
IBSP / Bone Sialoprotein Protein - Western validation with an anti-DDK antibody * L: Control HEK293 lysate R: Over-expression lysate
Select
293T Cells
Myc-DDK (Flag)
35.02 kDa
20 µg/$150
IBSP / Bone Sialoprotein Protein - (Tris-Glycine gel) Discontinuous SDS-PAGE (reduced) with 5% enrichment gel and 15% separation gel.
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E. coli
6His-SUMO, N-terminus
1 mg/$1,355; 100 µg/$420; 20 µg/$323
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E. coli
99 AA
His
Less than 0.1 EU/µg protein (determined by LAL method).
11 kDa
10 mg/$4,268; 5 mg/$3,201; 1 mg/$1,868; 0.5 mg/$1,475; 200 µg/$1,103; 100 µg/$756; 50 µg/$531
Select
Mammalian Cells
His,C-terminus
Less than 1.0 EU/µg protein (determined by LAL method).
35.1 kDa
10 µg/$266; 50 µg/$371
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Human
His, C-Terminal
Less than 1.0 EU/µg protein (determined by LAL method).
35.1kD
10 µg/$266; 50 µg/$376; 500 µg/$1,067; 1 mg/$1,369
Select
E. coli
His, N-Terminal
28.5kDa
10 µg/$283; 50 µg/$452; 200 µg/$905; 100 µg/$725; 1 mg/$2,020; 500 µg/$1,558; 5 mg/$3,165; 2 mg/$2,209
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PLEASE NOTE

For RESEARCH USE ONLY. Intended for use by laboratory professionals. Not intended for human diagnostic or therapeutic purposes.

The data on this page has been compiled from LifeSpan internal sources, the National Center for Biotechnology Information (NCBI), and The Universal Protein Resource (UniProt).